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Full-Text Articles in Physical Sciences and Mathematics
Investigation Into The Biological Importance And Function Of Proinsulin C-Peptide, Christina L. Newsome
Investigation Into The Biological Importance And Function Of Proinsulin C-Peptide, Christina L. Newsome
Theses, Dissertations and Capstones
The C-peptide of insulin was thought to be biologically inactive, but recent studies have shown that the C-peptide causes multiple molecular and physiological effects. Evidence has shown that C-peptide binds to a cell surface receptor, probably a G-protein coupled receptor, and that the COOH-terminal pentapeptide is essential for binding and constitutes an active site. For a further understanding of the detailed nature of the physiological effects of C-peptide, the receptor structure needs to be determined. We designed an affinity column using C-peptide to try and gain a better understanding of the biological effects by examining what proteins the affinity column …
Investigation Into The Cellular Actions Of Carnosine And C-Peptide, Emma H. Gardner
Investigation Into The Cellular Actions Of Carnosine And C-Peptide, Emma H. Gardner
Theses, Dissertations and Capstones
Carnosine is a dipeptide composed of beta-alanine and histidine found exclusively in long-lived animal tissues. The cellular action of carnosine is still under extensive investigation; however, it has been proposed to have a role as an anti-oxidant and oxygen free radical scavenger, a physiological buffer, a heavy metal chelator, and has been implicated as an anti-aging agent.2,4 Our lab has been studying the interaction between carnosine and heme by analyzing both the effect carnosine has on the glycation of the heme containing protein cytochrome c and the interaction of carnosine with free hemin. We have observed that the addition …