Physical Sciences and Mathematics Commons^™

Analysis Of Tyrosine And Its Halogenated Forms And Tripeptide –Metal Ion Clusters Using Mass Spectrometry, Bharathi Gannamani

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Chapter 1:

The aim of this research project was to measure the differences in proton affinities of tyrosine and its halogenated forms, 3-chlorotyrosine and 3-iodotyrosine. Tandem mass spectrometry was used here to measure the proton affinities. These amino acids were formed as protonated dimers with amino acids of known proton affinity and were introduced into the instrument through electrospray ionization (ESI). Based on the intensities of the protonated amino acids appeared in the mass spectrum when the dimer was isolated and fragmented, the proton affinities of the sample amino acids were calculated.

Chapter 2:

The research project was on mass …