Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Carbohydrates (2)
- Synthesis (2)
- Acetylcholinesterase (1)
- Affinity Cleavage (1)
- Amino acid (1)
-
- Amphiphile (1)
- Analytical chemistry (1)
- Antibiotic (1)
- Antimicrobial resistance (1)
- Automation (1)
- Cyclic phosphates (1)
- Cyclophostin cyclipostin enlphosphate enolphosphonate inhibitor serine hydrolase esterase lipase acetylcholinesterase hormone-sensitive tuberculosis organophosphorus (1)
- DNA (1)
- DNase I footpinting (1)
- Diabetes (1)
- Electrophoresis (1)
- Environmental (1)
- Fusion enthalpy (1)
- Germanium (1)
- Germole (1)
- HPLC (1)
- HPV (1)
- Hormone sensitive lipase (1)
- Human papillomavirus (1)
- Inorganic (1)
- Intramolecular Glycosylation (1)
- Ion (1)
- Lipid (1)
- Lipofection (1)
- Luminescence (1)
Articles 1 - 9 of 9
Full-Text Articles in Physical Sciences and Mathematics
The Synthesis And Characterization Of Photoluminescent Conjugated Frameworks Containing Silicon And Germanium, Douglas William Hammerstroem
The Synthesis And Characterization Of Photoluminescent Conjugated Frameworks Containing Silicon And Germanium, Douglas William Hammerstroem
Dissertations
Siloles and 9-heterofluorenes (Si, Ge) are conjugated π-electron systems containing Group 14 atoms which demonstrate unique properties such as high electron affinity, mobility, and bathochromically shifted optical spectra relative to their all-carbon analogs. This is due to their low-lying lowest-unoccupied molecular orbital (LUMO) which is resultant of the σ*-π* conjugation between the exocyclic groups at the Group 14 center and the butadiene unit of the ring. As a consequence, they have received considerable attention for their use as components for a wide variety of optical and electronic applications such as organic light emitting diodes (OLEDs), photovoltaic devices, field-effect transistors (FETs), …
Development Of An Hplc-Based Oligosaccharide Synthesizer, Salvatore Pistorio
Development Of An Hplc-Based Oligosaccharide Synthesizer, Salvatore Pistorio
Dissertations
Carbohydrates are the most abundant molecules on Earth. They are involved in a wide range of fundamental biological processes: anti-inflammation, immune response, joint lubrication, cell growth, antigenic determination. Carbohydrates are also held responsible for many damaging cellular processes, such as bacterial and viral infections, development of tumors, etc.. Therefore, the development of effective methods for the synthesis of complex carbohydrates has become a critical area of glycosciences. One challenge that stands out is the stereocontrol in the synthesis of glycosidic bonds, the linkage that serves as the only means to connect simple monosaccharides into complex oligomeric networks. Beyond this, the …
In Vivo And In Vitro Studies Of Polyamides That Are Active Antiviral Agents Against Hpv16, Edith Csiki-Fejer
In Vivo And In Vitro Studies Of Polyamides That Are Active Antiviral Agents Against Hpv16, Edith Csiki-Fejer
Dissertations
Long-term, persistent infection with high-risk strains of human papillomavirus (HPV) is the precursor of most cervical cancers and an increasing number of the head and neck cancers. While HPV vaccines can protect patients under twenty-five years old from possible infections, no HPV antiviral drugs are available for the definitive treatment of preexisting or future viral infections. To treat current or future HPV infections, drugs that selectively block virus-specific processes, but do not damage the host cells, are needed. The compounds developed in our group are unique Imidazole-pyrrole polyamides, analogs of natural products Distamycin A and Netropsin that function by interfering …
Synthesis And Characterization Of Amphiphiles For Mammalian Cell Transfection And Antimicrobial Activity, Joseph William Meisel
Synthesis And Characterization Of Amphiphiles For Mammalian Cell Transfection And Antimicrobial Activity, Joseph William Meisel
Dissertations
Amphiphiles are molecules that contain both water-soluble and water-insoluble components. The dual nature of these molecules engenders remarkable properties including the ability to self-assemble into ordered structures. Cell membranes are composed of amphiphilic phospholipids that organize into a bilayer motif. Synthetic amphiphiles can interact with natural membranes and influence the transport of molecules across the cell membrane. The work elaborated in this report employs amphiphiles to co-assemble with DNA and transport the genetic material across cell membranes. First, a simplified method for interacting DNA with amphiphiles was developed. Second, a series of known ion-transporting compounds were assayed for their interaction …
Study Of Vaporization Enthalpies And Vapor Pressures Of Potential Environmental Pollutants By Correlation-Gas Chromatography, Chase Patrick Gobble
Study Of Vaporization Enthalpies And Vapor Pressures Of Potential Environmental Pollutants By Correlation-Gas Chromatography, Chase Patrick Gobble
Dissertations
The focus of this dissertation is on the measurement and analysis of thermodynamic data, including vaporization, fusion, and sublimation enthalpies and vapor pressures of dialkyl phthalates, as well as aliphatic and aromatic primary and tertiary amines by correlation gas chromatography (CGC). These compounds are important industrial and pharmaceutical substances whose prolonged use and sometimes misuse with regards to their disposal has created an environmental concern. Thermodynamic properties, such as vaporization enthalpy and vapor pressure provide crucial information to numerous industries and fields of study that include the chemical and petrochemical industry, chemical engineering and environmental science. Dialkyl phthalates are essential …
Templated Oligosaccharide Synthesis, Jia Guang Xiao
Templated Oligosaccharide Synthesis, Jia Guang Xiao
Dissertations
Glycosyl transfer within the active site of an enzyme involves the arrangement of the gly-cosyl donor and glycosyl acceptor in close proximity to each other. To mimic this pro-cess, intramolecular glycosylations are carried out where the donor and acceptor are linked together via a spacer. Correct orientation, rigidity and position of the spacer play a vital role in the selectivity and yield of reactions in this “molecular clamp method”. Though current methodologies show promising results in terms of yield and selectivity, the need to synthesize different complexes to ensure selectivities in all types of glycosidic linkages is a large deterrent …
Synthesis Of Cyclic Enolphosphonates And Enolphosphates As Inhibitors Of Serine Hydrolases, Benjamin Patrick Martin
Synthesis Of Cyclic Enolphosphonates And Enolphosphates As Inhibitors Of Serine Hydrolases, Benjamin Patrick Martin
Dissertations
Cyclophostin is a potent naturally occurring inhibitor of acetylcholinesterase with a novel bicyclic enolphosphate structure. The cyclipostins are a family of potent hormone-sensitive lipase inhibitors which share the same bicyclic enolphosphate core structure with cyclophostin which but differ primarily in that they are long-chain alkyl phosphate esters whereas cyclophostin is a methyl phosphate ester. Due to the novelty of the inhibitor structure, potency, and ability to select between two serine hydrolase enzymes with a simple change in the ester substituent, the ongoing structure activity relationship investigation of this family of inhibitors was continued. Methods of transesterification were investigated in order …
Binding Properties Of Large Antiviral Polyamides (Pa1 And Pa25) And Natural Product Derivatives As Inhibitors Of Serine Hydrolases, Elena Vasilieva
Binding Properties Of Large Antiviral Polyamides (Pa1 And Pa25) And Natural Product Derivatives As Inhibitors Of Serine Hydrolases, Elena Vasilieva
Dissertations
Polyamides are a class of DNA minor groove binders that were developed from the natural product Distamycin A. PA25 (20-ring PA) showed better activity (3-fold) in the elimination of HPV16 episomes than PA1 (14-ring PA). Binding studies of PA1 and PA25 were performed in the long control region of HPV16 (7348-122 bp). PA1 showed similar binding affinity to perfect match and single mismatch binding sites. PA1 bound to double, triple, and quadruple mismatch sites with lower affinity. PA25 bound with similar binding affinity to perfect through triple mismatch binding sites. PA25 bound quadruple mismatch sites and nonspecifically. Therefore, it was …
Applications Of Nanoporous Gold Monoliths As Substrates For The Capture And Release Of Lectins And Glycoproteins, Allan Jonson Alla
Applications Of Nanoporous Gold Monoliths As Substrates For The Capture And Release Of Lectins And Glycoproteins, Allan Jonson Alla
Dissertations
Nanoporous gold (np-Au) monoliths are a free-standing nanostructured material with typical pore dimensions in the tens of nanometers range. The microstructure of np-Au resembles those of macroporous monolithic materials being used in chromatographic separations. The surfaces of np-Au monoliths were modified via flow methods with different ligands to develop affinity substrates for separations. A carbohydrate-modified np-Au monolith was prepared by immobilizing thiolated saccharides and further used to separate lectins. The np-Au monolith surface was also functionalized with self-assembled monolayers (SAMs) of α-lipoic acid (LA) followed by activation of carboxyl terminal groups to create amine reactive esters. Concanavalin A (Con A) …