Physical Sciences and Mathematics Commons^™

Formulation Development Of A Polymer-Drug Matrix With A Controlled Release Profile For The Treatment Of Glaucoma, Eric W. Tsoi

Master's Theses

Glaucoma is the leading cause of blindness in the United States accounting for 9-12% of all cases of blindness. Currently, the front line treatment for glaucoma are prostaglandins that may have to be taken up to several times a day. Even with proper treatment, roughly 11% of the patients using the treatment are non-compliant and lose their vision. In this project, ForSight Laboratories has developed a pharmaceutical drug delivering implant with the capability of sustaining long-term release of a prostaglandin as a new way to treat the condition. This project reports the product development of a polymer drug matrix with …

Phase Behavior And Rheology Of Latex, Thickener, Surfactant Mixtures And Liquid Crystal Based Compositions For Printing High-Efficiency Flexible Electronics, Franceska Anna Santos

Master's Theses

This project consists of two parts. One area of focus in the first part is understanding the interactions between a non-ionic, block copolymer type dispersant and hydrophobically-modified, ethoxylated urethane (HEUR) associative thickeners in water. The dispersant was mixed at various concentrations (0-2% by weight) with HEUR thickeners at 1% by weight concentration in the aqueous medium. This study is an integral part of our attempts to determine mechanisms of viscosity drop when colorant dispersions are added to latex tint base formulations thickened with associative thickeners. One of the HEUR thickeners is a product that has been available for over three …

The Influence Of Hydrogeomorphology, Soil Redox Conditions, And Salinity On The Spatial Zoning Of Saltgrass, Salt Rush, And Cattails In Scotts Creek Marsh, Swanton Pacific Ranch, Ca, Mark D. Gormley

Master's Theses

Scotts Creek Marsh (SCM) is a small coastal wetland ecosystem in Davenport, CA. The vegetation of SCM is dominated by three halophytic zones comprised of saltgrass, salt rush, cattails. The objectives of the study were (i) to investigate the variables that influence the zoning of the three dominant halophyte communities in SCM and (ii) to the test the effectiveness of Indicator of Reduction in Soil (IRIS) tubes to indicate the reduction of S. The study examined the following parameters from April 6 to July 21, 2013: (i) the HGM of Scotts Creek Marsh, (ii) soil oxidation and reduction (redox) conditions, …

Nanoparticles And Polymer Crystallization Kinetics In Hybrid Electronic Devices, Taylor William Wagner

Master's Theses

Conjugated semi-conducting polymers have become well known for their potential applications in hybrid electronic devices like solar cells, LEDs, and organic displays. These hybrid devices also contain inorganic nanoparticles, which complement the polymer when they are combined into the same layer. Control over the conformation and crystallinity of the polymer is critical for device performance, yet not much is known about the effect that these nanoparticles have on the polymer. Here, zinc oxide nanowire was surface modified with mono-substituted-carboxylic acid tetraphenylporphyrin and dodecanethiol, and introduced to poly(3-hexyl thiophene) in solution. The electron transfer, kinetics, and thermodynamics of this system were …

Lipid Production By Microalgae Treating Municipal Wastewater, James Edward Kelley

Master's Theses

Microalgae hold much promise as a feedstock in liquid biofuel production. Lipid content of microalgae cells range from 30-80% dry weight of biomass. It is projected that microalgae can produce between 1,000-6,500 gallons/acre/year of oil. Currently, production of industrial algae operates in open raceway ponds that use minimal capital and energy inputs to culture algae. Raceway ponds can also be used to grow microalgae from municipal waste streams. Although high biomass productivity can be achieved in these systems, there remains a large production gap between large volumes of biomass cultivation and high lipid content from microalgae cells. Low lipid content …

Morphology And Conformation Of Polythiophene Derivatives In Anisotropic Core-Shell Nanocomposites And Solution, Neil Redeker

Master's Theses

Conjugated semiconducting polymers have garnered substantial interest in recent years due to the potential for use in various applications, particularly in the field of electronic devices such as photovoltaic cells and light emitting diodes. Conjugated polymers offer numerous advantages in these applications, including low cost and high flexibility, but electronic devices based on these materials are currently limited by poor performance. Because of these limitations, increased focus has been placed on improving conjugated polymers for use in commercially viable products. Here, a novel core shell hybrid nanocomposite based on anisotropic zinc oxide nanowires and a side-chain functionalized polythiophene is reported. …

Re-Healable Coating Based Upon Thermally Responsive Linkages, Dahlia Ningrum Amato

Master's Theses

The goal of this thesis was to design thermally responsive polyol resins that would be compatible with isocyanates. Two approaches were made to reach this goal, the first involved functionalizing soybean oil and the second involved post-polymerization modification of a methacrylate based resin.

A soybean based coating with thermally responsive Diels-Alder linkages has been prepared following an automotive two-component formulation. The resulting coatings displayed the capability to be healed following physical deformation by a thermal stimulus, and such a material has significant potential for end users. Various curing agents were employed, and resulted in variation of scratch resistance and re-healablity. …

Latent Cysteine Residues From Polymers Prepared Via Free And Controlled Radical Polymerizations, Douglas Vincent Amato

Master's Theses

One less commonly used “click” reaction is thiazolidine chemistry. Thiazolidine chemistry is a commonly used reaction used in biological systems because the reaction requires the presence of both cysteine (a common amino acid) and an aldehyde or ketone. If cysteine residues could be incorporated into a polymer then a variety of applications could be developed. Polymers containing free thiols (aka thiomers) have developed in the last decade to become great mucoadhesives. If there was a facile route to control the amount of free thiols along the polymer then more fine-tuned and potentially stronger adhesives could be made. For these reasons …

Experimenting With Polymer Blend Solar Cells And Active Layer Thickness, Ryan Blumenthal

Physics

Bulk heterojunction organic photovoltaics utilize the electrical characteristics of semi-conductive polymers. These solution processable materials are beneficial because of their low material cost, light weight, and simple fabrication requirements. Our devices employ multiple photoactive polymers, P3HT and PCPDTBT, to absorb photons over a wide spectral range. We optimized various device characteristics including thickness and thermal anneal usage to reach a power conversion efficiency of 3.0% in AM1.5 sunlight. Device performance degrades over time due to atmospheric water and oxygen, prompting us to investigate device packaging to extend cell lifetime for additional testing.

Density Functional Theory And The Calculation Of Tcmg2O4 Spinel Lattice Parameters, Jon Karlo Macias

Physics

The cohesive energy, lattice constant and bulk modulus of two simple HCP crystal structures of magnesium and technetium were calculated using the vienna ab initio simulation package (VASP) which is based on density functional theory (DFT). The same properties were determined for TcMg₂O₄ spinel. The theoretical results of the lattice constant of the pure crystals were compared to experimental results and found to be in excellent agreement with a difference of less than 2%. The results for the lattice constant of the TcMg₂O₄ spinel were found to be in excellent agreement as well with …