Physical Sciences and Mathematics Commons^™

Design Of Control Release Drug Delivery System (Dds) For Imaging And Therapeutic Applications, Sweta Naik

Theses and Dissertations

The main challenge in disease treatment is no more the discovery of new therapeutic drugs, but to provide targeted delivery of therapeutic drugs to specific sites without incurring systemic toxicity effects. An efficient way of reducing the toxicity is by encapsulating the drug with a biodegradable matrix that can provide controlled release of the drug along with local heating of the drug. Local heating can be obtained by incorporating magnetic iron oxide particles that heat upon exposure to AC electromagnetic fields. The magnetic iron oxide nanoparticles are also gaining much attention as MRI contrast agents. Thus it would be of …

Novel Ruthenium Complexes As Photodynamic Therapeutic Agents, Sareen Kumar Kushangari

All Capstone Projects

This project reviews the literature of novel ruthenium c complexes in photodynamic drug therapy. (Abstract by OPUS staff)

Synthesis Of A Folate Receptor Mass Spectrometry Probe, Audrea Rhymes

All Capstone Projects

Drug delivery is one of the most important concepts for cancer patients because it is oftentimes very difficult or nearly impossible to exclusively target cancerous cells. In this study, the aim was to target receptors on cancerous cells, specifically the Folate Receptor (FR). This specific receptor was targeted because it has been proven to enhance intracellular delivery being that folic acid is an integral species in normal cell function and also that cancerous cells tend to exhibit an abnormally high concentration of Folic Acid on cell surfaces.

The application of dyes is a very common practice used to link folic …

Encapsulated Antibiotic Nanoparticles For Cranial Transplantation, Adusumilli Naga Anusha

All Capstone Projects

The purpose of this research is to develop a unique nanoparticulate system that is capable of delivering antibiotics in a locally applied and extended-release manner for patients receiving cranial replacement implants and bone grafting. This study involves three major components: first, encapsulate both hydrophobic antibiotics (chloramphenicol and rifampicine) and hydrophilic antibiotics (vancomycine and acyclovir) into nanoparticles. Second, incorporate antibiotic nanoparticles in a polymeric coating material (nitrocellulose plus 7.0% (w/v) polyvinylpyrrolidone) with a volatile carrier solvent (ethyl acetate or ethanol). Third, directly apply the resulting product from component 1 and 2 to polymethyl methacrylate (PMMA) cranial implants and hydroxylapatite (HA) bone …

Nanoencapsulated Drug-Carrying System For Photodynamic Antimicrobial Chemotherapy (Pact), Gopala Krishna Murthy Kalapala

All Capstone Projects

The purpose of this study is to develop nanoparticulate drug-carrying systems that are capable of directly delivering photodynamic antimicrobial agents to treat patients with chronic wounds. Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States, according to the American Academy of Dermatology, the expense of treating chronic wounds constitutes over half of the total cost for all skin diseases, which exceeds $10 billion annually. For the last decade extensive basic science and clinical research in chronic wounds …

Anti-Solvent Precipitation And Subsequent Film Formation Of Hydrophobic Drugs For Drug Delivery, Xiangxin Meng

Dissertations

It is estimated that about forty percent of the drug molecules being developed by the pharmaceutical industry are hydrophobic in nature, leading to poor water solubility and bioavailability in the gastrointestinal tract. Dissolution is a limiting factor in their in vivo performance, and increasing their dissolution rate is a major challenge. It has been proven that the dissolution rate is directly proportional to the specific surface area, which can be effectively increased by reducing the particle size. Therefore, considerable efforts have gone into developing reliable and efficient methods for the manufacture of fine particles. Particle size reduction technologies such as …

Design And Synthesis Of A New Class Of Self-Cross-Linked Polymer Nanogels, Siriporn Jiwpanich

Open Access Dissertations

The design and engineering of nanoscopic drug delivery vehicles that stably encapsulate lipophilic drug molecules, transport their loaded cargo to specific target sites, and release their payload in a controlled manner are of great interest in therapeutic applications, especially for cancer chemotherapy. This dissertation focuses on chemically cross-linked, water-soluble polymer nanoparticles, termed nanogels, which constitute a promising scaffold and offer the potential to circumvent encapsulation stability issues. A facile synthetic method for a new class of self-cross-linked polymer nanogels, synthesized by an intra/intermolecular disulfide cross-linking reaction in aqueous media, is described here. This simple emulsion-free method affords noncovalent lipophilic guest …

Detection Of Folate Receptor From Fr+ Cancer Cells, Darpan Patel

All Capstone Projects

The aim was to detect cancer cells by using folate–PEG-Biotin probe with fluorescently labeled streptavidin for targeted drug delivery of anti-cancer drugs and diagnose cancer cells. Folate-PEG-Biotin (synthesized by Dr. Henne and Mr.Rohan Patel) was purified by HighPeformanceLiquidChromatography (HPLC) analysis and with the help of Liquid Chromatography/Mass Spectrometry (LC/MS) its identity was confirmed. Folate is a basic composition of cell metabolism in both synthesis of DNA and proteins. Growing cancer cells require high level of folic acid. Folate Receptor-α (FR-α) is a membrane bound protein having high affinity for folic acid and serves to transport of folate into cells. Poly …

Evaluation And In Vitro Studies Of Folate-Peg-Biotin, Kuldeep Reddy Vanga

All Capstone Projects

Folate receptor is a membrane bound protein which is highly expressed by cancer cells and macrophages. Folic acid is required for the normal growth of cells and it has been found that rapidly growing cancer cells require high levels of folic acid. Folic acid binds to folate receptors and through receptor mediated transport folate enters cells. This property has been used to synthesize a probe using folate as ligand through polyethylene glycol-Biotin linker. This can be used to attach a drug which is ultimately delivered at the site of infectious cells. The study involved here was to determine how folate …

Redox-Active Liposome Delivery Agents With Highly Controllable Stimuli-Responsive Behavior, Nicole Hollabaugh Carrier

LSU Doctoral Dissertations

Over the last few decades, liposomes have generated a lot of interest as drug delivery vehicles to address the need for providing both increased therapeutic efficacy and decreased systemic exposure, simultaneously. The challenge of increasing drug accumulation at diseased sites, without compromising the integrity and stability of the liposomal carrier during circulation, has been met with two possible solutions: (1) active targeting and (2) active triggering. To achieve selective and site-specific delivery of drugs to tumors, active triggering methods have been developed wherein a responsive element is incorporated into the liposomal bilayer, which causes destabilization of the liposome upon exposure …

Characterization Of Triggerable Quinones For The Development Of Enzyme-Responsive Liposomes, Maria Fabiana Mendoza

LSU Doctoral Dissertations

For decades, there has been a lot of focus on the development of new carriers for drug delivery applications. From all of the carriers, stimuli-responsive liposomes have been studied extensively, but only a handful have been enzyme-responsive liposomes. Therefore, the field of endogenous proteins as activators of liposomes is a fertile field worthy of exploration. The research described in this dissertation involves how structural changes on the quinone moiety altered their electronic properties, as well as their behavior toward the human enzyme NAD(P)H:quinone oxidoreductase type-1 (hNQO1, over expressed in certain tumor tissues), thus yielding a series of triggerable quinones to …