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Full-Text Articles in Physical Sciences and Mathematics
The Effects Of Exogenous Insulin And Exercise On Glucose And Lactate Metabolism In The Brown Anole, Anolis Sagrei, Kristen Marie Hitchcox
The Effects Of Exogenous Insulin And Exercise On Glucose And Lactate Metabolism In The Brown Anole, Anolis Sagrei, Kristen Marie Hitchcox
Honors Theses
Blood glucose homeostasis is tightly regulated in mammals. Insulin and exercise both stimulate glucose uptake into muscle cells via the GLUT4 transporter protein by independent pathways. Insulin triggers a tyrosine kinase pathway, but the mechanism stimulated by exercise is unknown. Discovering the mechanism may provide new therapeutic techniques for people with diabetes mellitus. While mammals have been studied extensively, research on a different model may elucidate aspects of this lesser known pathway. Reptiles rapidly deplete glycogen stores during bursts of activity and produce lactate as a byproduct of anaerobic metabolism. Lactate undergoes gluconeogenesis within muscle tissue, rather than liver tissue, …
Mechanisms Of Cytotoxicity Of Diepoxybutane, Epichlorohydrin And 1-(Chloroethenyl)Oxirane, Rebecca D. Kamins
Mechanisms Of Cytotoxicity Of Diepoxybutane, Epichlorohydrin And 1-(Chloroethenyl)Oxirane, Rebecca D. Kamins
Honors Theses
Diepoxybutane (DEB), epichlorohydrin (ECH), and 1-(chloroethenyl)oxirane (COX) are small molecules that can form DNA interstrand cross-links. All three of these compounds are, or are metabolites of, industrial chemicals linked to cancer. Additionally, DEB is a metabolite of treosulfan, an anti-cancer drug. We are trying to determine why some of these compounds cause cancer and some can also cure cancer. To do so, we are attempting to link cytotoxicity, cross-linking efficiency, and apoptotic potential of the three compounds to see if any correlations exist. The purpose of this project was to quantify apoptotic potential of DEB, ECH and COX. This was …
Changes In Apoptotic Gene Expression Induced By Dna Cross-Linkers, Jordanne B. Dunn
Changes In Apoptotic Gene Expression Induced By Dna Cross-Linkers, Jordanne B. Dunn
Honors Theses
The Millard Research Laboratory is interested in the cytotoxic mechanisms of the bifunctional alkylators diepoxybutane (DEB), epichlorohydrin (ECH), and (1-chloroethenyl) oxirane (COX). Studies performed in the laboratory examine the dual nature of these DNA cross-linking compounds that can act as carcinogens or anti-cancer agents. The mechanisms through which these compounds induce cell death are explored in this study. Cells either undergo cell death due to necrosis or apoptosis. HL-60 cells were treated with varying concentrations of DEB, ECH, or COX. A caspase 3/7 assay was used to test for induction of apoptosis in the treated cells at varying incubation times. …