Physical Sciences and Mathematics Commons^™

Synthesis And Properties Of Diorganomagnesium Compounds, Conrad William Kamienski

Doctoral Dissertations

Introduction: Although dialkylmagnesium compounds have been known for over a hundred years, relatively little effort has been directly expended on these reagents per se; much of what we know about magnesium alkyls has been an outgrowth of previous studies concerned with the nature of the Grignard reagent. Only recently has any effort been made to elaborate on methods for preparing these reagents, to determine carefully their physical and chemical properties, and to develop practical uses for these reagents. It has been the purpose of the present study to review the presently known methods of preparation of dialkylmagnesium compounds, to …

The Evaluation Of Certain Serum Iron Analyses By Atomic Absorption Spectroscopy, James Allan Boersma

Masters Theses

No abstract provided.

An Indirect Spectrophotometric Method For Expansion Of The Optimum Concentration Range, Henry David Mitchell

Masters Theses

No abstract provided.

Pyrolysis Kinetics Of Ethyl Nitrate, Betty Meihorng Lee

Masters Theses

No abstract provided.

A Study Of The Synthesis And Reactions Of Condensed Pyriadazines, Lorraine Marie Distefano

Chemistry and Chemical Biology ETDs

A special interest in a nitramine rearrangement prompted the preparation of 1,4-diaminopyridazino [4,5-d] pyridazine and the nitration of this compound. Several reactions of the intermediates, which were synthesized en route to 1,4-diaminopyridazino [4,5-d] pyridazine, were studied. Strong evidence for the existence of keto-enol tautomerism was found in the case of 1,4-dihydroxypyridazino [4,5-d] pyridazine and its derivatives.

Some reactions of 5, 8-dichloropyrazino [2,3-d] pyridazine were studied with particular interest in the nucleophilic displacement of azides and in the nitration of 5,8-dianilinopyrazino [2,3-d] pyridazine.

The nitration of diaminophthalazine was also attempted in order to perform an acid catalyzed nitramine rearrangement from one …

Radiolysis Of The Extract From The Sawdust Of The Ponderosa Pine, Mervin B. York

Loma Linda University Electronic Theses, Dissertations & Projects

Portions of an acetone-hexane (1:4) extract of Ponderosa pine sawdust were exposed to gamma and ultraviolet radiation. The three solutions, including the original, were checked for antibiotic activity on: Staphylococcus aureus Escherichia coli and Bacillus cereus. Results indicated that each solution inhibited the growth of the bacteria.

The three solutions were separated into fractions by 'column' chromatography on silica gel, using chloroform-carbon tetrachloride (1:1) as the elutant and then 10-20-50-80% ethanol in the chloroform- carbon tetrachloride mixture and finally 100% ethanol. Ten fractions were obtained from each sample and these were each tested on the bacteria. Results indicated a number …

Approach To Nickel-Tin Alloy Electrodeposition And Parameters Of The Nickel Tartrate Complex, Kenley R. Lee

Masters Theses

Statement of Problem

The study of conditions required for the electrodeposition of a nickel-tin alloy from baths other than the fluoride bath and the acetate bath was undertaken. The research included the correlation of thermodynamic and kinetic properties of electrode processes fro the electrodeposition of the alloy desired.

The research also included the determination of the formula and formation constant of the nickel tartrate complex. The tartrate ion was a possible constituent in a bath for the electrodeposition of the alloy.

Preliminary Studies On The Mechanism Of The Rupe Reaction, Ann D. Anderson

All Master's Theses

The purpose of this study is to analyze the products of the Rupe reaction and the optimum conditions for their formation. Studies on product formation as a function of time were also necessary to detect any intermediate compounds.

Thermodynamics Of Metal-Ligand Interactions In Solution I. The Thermodynamics Of Metal-Cyanide Interaction ; Ii. Application Of The Entropy Titration Technique To Metal-Ligand Systems ; Iii. Log K, [Delta]H And [Delta]S Values For The Interaction Of Sulfate Ion With Metal Ions ; Iv. Interaction Of Mercuric Cyanide With Thiourea In Water-Ethanol Solvent Mixtures, Delbert J. Eatough

Theses and Dissertations

Log K values, valid at zero ionic strength are reported for the interaction in aqueous solution of CN- with Ni2+ and Hg2+ at 10°, 25° and 40°C, and with Pd2+ at 25°C. ∆H° and ∆S° values valid at zero ionic strength and 25°C are also reported for the interaction of CN- with Hg2+ and for the reaction Pd(CN)42- + CN- = Pd(CN)53-. In connection with the study of Pd2+ - CN- interaction, log K values for the hydrolysis of Pd2+ to give PqOH+ and Pd(OH)2 and an E° value for the reaction Pd(s) = Pd2+ + 2e- are reported. A …

The Synthesis Of 3-Hydroxy-4-Imidazolidiones, Victor L. Rizzo

Masters Theses

No abstract provided.

Preparation And Spectral Studies Of Heterocyclic Hydrazone Analogs, Michael Mcaneny

Masters Theses

No abstract provided.

Secondary Reactions And Partial Rate Factors In The Sulfonation Of Chlorobenzene And Toluene, Ernest Arthur Brown

Theses and Dissertations

The sulfonation of chlorobenzene, chlorobenzene-benzene, and toluene-benzene mixtures by sulfur trioxide in liquid sulfur dioxide at -12.5° C. was studied to obtain isomer distribution and relative rate data. The isomer distribution for the reaction on chlorobenzene was determined by an isotope dillution technique. Relative rate experiments were conducted by sulfonating C14 labeled benzene in competition with nonradioactive chlorobenzene and toluene and the count rate of the products was used to determine product composition. Ultraviolet spectrophotometry was also used to investigate variations in isomer distributions as a function of sulfur trioxide concentration. The apparent relative rates of sulfonation (kX/kB) as calculated …

A Spectral Study Of The 4-Arylamino-1,2-Naphthoquinone System, Lloyd Myles Phipps

Masters Theses

No abstract provided.

Thermal And Photochemical Decompositions Of The Chloride Salt Of Ortho-Diazoiumphenlyacetic Acid, John Oliver Rosser

Honors Theses

Ortho-nitro-phenylacetic was synthesized, diazotized, and subjected to thermal and photochemical decomposition. Indazole is formed when the diazonium chloride salt was thermally decomposed in water. When carbon tetrachloride was used as a solvent, a lactone-like product was formed. When an excess of pyridine in carbon tetrachloride was used no decomposition took place. Photochemical decompositions using a mercury vapor lamp resulted in a combination. of products when methanol was used as solvent and indazole when water was the solvent.

A Qualitative Study Of The "Bohlmann Band", John Alfred Richman Jr.

Master's Theses

This thesis is concerned with a qualitative study of the "Bohlmann Band", a result of C-H stretching frequencies, which is often observed in the 3.57 to 3.70 μ region in the infrared absorption spectra of amines. The appearance of this band is characteristic of tertiary amines although a few exceptions have been encountered.

The Formation Of Tertiary Butyl Phenyl Ether By A Diazonium Salt Decomposition, Allan Richard Bernstein

Honors Theses

Diarryl ethers have been prepared by various candidates for master's and bachelor's degrees at Union College in the past. Ulmann reactions were involved, but with some variability in yields and some rather lengthy syntheses. More recently, decompositions of diazonium salts have been studied for preparation of aryl ethers. This might constitute a simpler or more efficient synthetic route.

Rearrangements Of N-Nitrosolactams, Dennis Stuart Gordan

Honors Theses

The experiments reported here were done in an attempt to fill in the gap in Huisgen's work on N-nitrosolactams (1) - the synthesis and subsequent rearrangements of the six-membered-ring compounds of this type (I, ni2).

Synthesis And Absorption Spectra Of 2,4,6-Trihlorodiphenyl Ether, Dominic Louis Poccia

Honors Theses

The repeat of Schwab's work confirmed his experimental results for the reaction of the pseudo-hypochlorite of 2,4,6-trichlorophenol with benzene and anhydrous alumnium chloride.

An Attempt To Prepare Methyldiphenylsulfonium Fluoroborate, William Harvey Holley

Honors Theses

In the past few years there has been growing interest in two types of organic salts, those of sulfonium and oxysulfonium ions. Probably the better known are the sulfonium compounds. In general they are crystalline salts, and thet are water soluble giving neutral solutions. The trialkyl sulfoniym ion (fig. 1), like the quaetenary ammonium ion, has the tetrahedral structure except that in the sulfonium ion the fourth group is an unshared pair of electrons rather than a bonded group.

Ion Exchange Resin Impregnated Paper Chromatography Of Some Typical Chlorinated Pesticides, Stephen F. Nagy

Honors Theses

The purpose of this project was to examine the effect the ionic immobile phase of various ion exchange resin-impregnated papers has on the separability of some typical chlorinated pesticides; the ultimate goal was devising an ion exchange resin-impregnated paper chromatographic system which would provide better chlorinated pesticide resolution than conventional paper chromatographic methods.

Synthesis Of N-Benzyl-N-Methyl-Β-Chloro-Β(P-Chlorophenyl)-Ethylamine-Hydrochloride, Van Saxton Hubbard

Honors Theses

Classes of compounds often have similar characteristics and activities. However, it has been showin in pharmacological studies that a small change in a structure produced by a substitution of an atom or a group of atoms on the original compound may cause a marked change in biological activity. When a certain compound shows usefulness as a drug, many variations of this compound are studied to see if a more useful form can be made. Two characteristics looked for are (1) effectiveness, which includes the onset or how long before the drug takes effect, and the duration or how long the …

The Use Of Arsenic Trichloride As A Solvent In Nmr Spectrometry, Phillip Wills Haines

Honors Theses

Since Union College has had its Nuclear Magnetic Resonance Spectrometer, a great many organic compound have been analyzed. Several more might have been identified if they could have been dissolved in a suitable solvent. The expense of deuteratd solvents and the lack of suitable solvents for some compounds have led to the consideration of inorganic compounds for use as solvents.

The Hydroxylation Equilibrium Constant For 2,4 Dichlorobenzaldehyde At Various Temperatures, Gregory Richard Olson

Honors Theses

The primary objective of this work was to examine the temperature dependence of dissociation constants of hydroxylated substituted benzldehydes. The equilibrium of 2,3 dichlorobenzaldehyde in aqueos sodium hydroxide solutions has been studied at 35 degrees celsius with varying hydroxide ion concenctrations.

Metabolic Pathways For Methoxychlor In Rats, Frank Hastings Mckim

Honors Theses

The main approach of the experiment was to metabolize methoxychlor with rat liver microsomes since hepatic microsomes have been shown to contain many of the metabolic enzyme systems. The incubated sample was extracted with various solvents after hydrolysis. The extracts were separated and identified by thin layer or vapor phase chromatography. The structure of the metabolites were theoretically determined by studying the analogy between DDT and methoxychlor. A study of detoxification mechanisms also aided in establishing a theoretical metabolic chain.

Synthesis Of Fluorinated Acetyl Choline, Joel Beryl Loewenstein

Honors Theses

The purpose of this research was the practical synthesis of a fluorinated acetyl choline.

Synthesis And Reactions Benzyldiazonium-2-Carboxylate, Marc David Rudich

Honors Theses

The purpose of this research is to investigate the reactions of benzyldiazonium-2-carboxylate or a precursor to determine whether they offer a pathway to the preparation of benzocyclopropene.

Synthesis Of 2-(2,5-Dichloro-Phenyl) Tetrahydro-3 Methyl 1-4-H-1, 3 Thiozone-4-One 1,1-Dioxide And Study Of The Sommelet Reaction Mechanism, Alexander James Wall Iii

Honors Theses

The text of this thesis deals with two separate, but inter-related prob- lems. The first is the synthesis of 2-(2, 5-Dichloro-phenyl) Tetrahydro-3 methyl 1-4-H-l, 3 Thiozone-4-one 1, 1-Dioxide. The second is a study of the Sommelet reaction which was employed in the syn­thesis of the above compound. This project was undertaken to complete the syn­thesis of a group of analogous compounds which have been synthesized by Wilson and Downer for the Sterling Winthrop Drug Company. The compounds illustrated below have been tested and found to have varying potential as central nervous system depressants.

The Effect Of Dimethyl Sulfoxide And Acetic Acid On The Decomposition Of O-Methoxy, W-Diazo-Acetophenone, Andrew Laurence Colb

Honors Theses

The acid-induced decomposition of o-methoxy, w-diazo, acetophenone might proceed by wither of two pathways. Huisgen (1) postulated that the mechanism was either “catalytic” (equation 1) or “stoichiometric,” (equation 2) and the differences in the mechanisms were directly related to acid concentration, nucleophilic power of the anion of the acid, and the ionic strength of the medium. Sheffer’s (2) reactions with o-methoxy, w-diazo acetophenone were carried out in ether, a non-polar medium. The aim of this researcher’s study was to determine the reaction course for the decomposition of o-methoxy, w-diazo acetophenone, in a highly polar, slightly nucleophilic medium containing nucleophilic acetate …

A Study Of The Coordination Complex Dichlorobis - [1, 10 Phenanthroline] Cobalt (Iii) Chloride, Richard Carle Goodson

Honors Theses

One of the traditional areas of study in chemistry has been that of coordination chemistry. The concern of this study is with a particular coordination complex and hence, by way of introduction, something should be said about coordination chemistry. A considerable amount of work has been previously applied to the study of [Co(phen)2(Cl)2] Cl by Ablov and Palade (2) and by Pfeiffer and Werdelmann (3). Using different mehods each group prepared the cis form of the geometric isomers through the literature seems to indicate that neither group resolved the optical isomers of the cis form. Ruid (4) attempted to resolve …

Rates Of Deuterium Exchange From Deuterated M-Dichlorobenzene In Methanolic Sodium Methoxide Solutions, Rita Rose Boggs

Honors Theses

Rate constants were determined for deuterium exchange fro.m m-diohlorobenzene-2-d in 0.5 to 5 molar methanolic sodium methoxide solutions at 80.3° C.

Since this is a base catalyzed reaction, an attempt was made to correlate the rates with the appropriate basicity parameter. The methoxide ion concentration was an entirely inadequate parameter since a plot of log k1 against log [OCH3] showed a linear variation with a slope of 2.40. Significant correlation would demand a slope of unity. The D0 function provided correlation for all kinetic runs except those of sodium methoxide concentrations higher than 4.05 M. The H_ function failed to …