Physical Sciences and Mathematics Commons^™

The Study Of The Metal Complexes Of Alpha Aminohydroxamic Acids, Richard N. Nipe

Masters Theses

Introduction

The objectives of this investigation were to develop: 1) compounds similar to hydroxy urea, a compound known to have anti-tumor activity, 2) a method to prepare α-aminohydroxamic acids and to study the complexes of these compounds with several metal ions, 3) computer programs to determine the pK's¹ of the hydroxamic acids and the stepwise stability constants² for the ligands and several metal ions.

The values obtained for the stability constants were compared with values for the stability constants of acetohydroxamic acid and α-aminocarboxylic acids in an attempt to find which in the ligand formed bonds with the …

Studies On The Preparation Of Tetrasubstituted Hydrazones, William Kao

Masters Theses

Introduction

In a recent study of the ultraviolet spectra of substituted hydrazones, it was concluded that a sterio effect existed in tetrasubstituted hydrazones that significantly hindered complete rotation about the nitrogen-nitrogen bond. Weber¹⁶ noted that di- and tri-substituted hydrazones exhibited similar spectra with three strong absorption bands at approximately 235, 300, and 340 mu. In acid solutions, the spectra of these compounds showed a marked decrease in intensity of the long wavelength band. It has been postulated that this change was a consequence of the protonation of the non-bonding electron-pair on the amino nitrogen atom, and thus correlated the …

Synthesis Of A Substituted Tetrahydropyrimidopyrimidine, Jack Lee Parsons

Masters Theses

Introduction

The purpose of this research was to develop a generalized synthesis of substituted tetrahydropyrimidopyrimidines. It was also of interest to prepare related compounds for the purpose of structure determination.

We were interested in tetrahydropyrimidopyrimidines as possible folic acid antagonists.

The Application Of The Verwey-Overbeek Theory To The Relative Sediment Volume Of Kaolin-Water Dispersions, James E. Kline

Masters Theses

Introduction

This paper describes an investigation intended to: 1. observe the effect of electrolyte concentration on the stability of kaolin-water systems, 2. evaluate the relative sediment volume measurement as a tool for determining the stability of such systems, 3. assess the applicability of the Verwey-Overbeek theory of stability of lyophobic colloids for predicting the observed effects, and 4. determine if any correlation exists between the effects predicted by the theory and observed through the relative sediment volume measurement.

The relative sediment volume measurement will be shown to be dependent upon the efficiency of packing of the pigment particles, which in …

Dimethyl Sulfoxide Oxidation Of Primary Alcohols, Carmen Vargas Zenarosa

Masters Theses

Historical

A method of selective oxidation of primary and secondary alcohols to the corresponding aldehydes and ketones has been developed recently, namely the use of dimethyl sulfoxide (DMSO) as the oxidizing agent, either alone or with dicyclohexylcarbodiimide (DCC)¹⁴, acid anhydrides¹, or alkyl chloroformates¹⁰. The negatively polarized oxygen atom of the sulfoxide group in DMSO is ideally situated for a transfer to many electron-deficient substrates. The oxygen of the alcohol coordinates with the sulfur atom of DMSO through its oxygen atom; this is followed by β-elemination of dimethyl sulfide, thereby resulting in oxidation of the …

A Study Of The Base Catalyzed Decompositions Of Azoacetates, David V. Herman

Masters Theses

Introduction

The formation of a benzyne intermediate has been shown by several investigators ^(2,5,6) to be developed in at least four different reactions; the reaction of o-dihalobenzenes with magnesium or lithium, aryl halides with strong nucleophiles, o-halobenzophenones with potassium amide in liquid ammonia, and the decomposition of benzenediazonium-2-carboxylate.⁽¹³⁾ The mechanism propsed for one of the above most relevant to the following study, the reaction of o-halobenzophenones with potassium amide in liquid ammonia, is outlined in the following sequence:

Studies On The Ribosomal Ribonucleic Acids From Mesophilic And Thermophilic Bacteria, Alice A. Holazo

Masters Theses

Introduction

Certain organisms have been known to live at temperatures at which cellular constituents ordinarily sensitive to heat are destroyed. These organisms. called thermophiles (heat-loving), normally live at higher temperature range of the biokinetic zone (10^o-45^oC).

Hydrolysis Of Benzohydroxamic Acid, Robert L. Fuller

Masters Theses

Introduction

The hydroxamic acids were discovered in 1869 by H. Lossen¹. The nomenclature, structure, and chemistry of these compounds have been summarized in an excellent review article by Yale².

The Activity Of Succinic Dehydrogenase And Indole Acetic Acid Oxidase In Cell-Free Preparations Of Hygrophorous Conicus, Jagdish M. Mehta

Masters Theses

"The enzyme indole acetic acid oxidase is produced by the fungus Hygrophorous conicus when it is grown in the presence of indole acetic acid (IAA) or tryptamine. The IAA acts both as an inducer and a substrate for this intracellular enzyme. The product of the oxidation catalyzed by the IAA oxidase is oxindole acetic acid (OIAA).

The rate of growth and the rate of formation of the enzyme IAA oxidase by H.conicus were studied in different media. Of these, a nitrate medium containing 0.5 per cent Yeast extract (Y.E.) was found to be the best for the production of H.conicus …