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Full-Text Articles in Physical Sciences and Mathematics
End Group Modification Of Linear Dendritic Block Copolymers (Ldbcs), Chinwe Udemgba
End Group Modification Of Linear Dendritic Block Copolymers (Ldbcs), Chinwe Udemgba
Honors Theses
Linear dendritic block copolymers are amphiphilic molecules that consist of a dendritic hydrophilic portion and a linear hydrophobic portion. Its unique ability to self-assemble into spherical nanoaggregates while having the potential to uptake and transport both hydrophilic and hydrophobic drugs makes these polymers an item of interest in regard to the drug delivery field. The synthesis of polyamidoamine-polylactide linear dendritic block copolymers was designed to address the common issues in drug delivery systems, including problems in permeability, solubility, stability, specificity, and retention. Though this linear dendritic block copolymer has previously been synthesized in our lab with cationic amine surface functionalities, …
Elucidating The Interfacial Interactions Between Biomacromolecules And Functionalized Pamam-Based Materials For Biomedical Applications, Briana L. Simms
Elucidating The Interfacial Interactions Between Biomacromolecules And Functionalized Pamam-Based Materials For Biomedical Applications, Briana L. Simms
Electronic Theses and Dissertations
Polyamidoamine (PAMAM) is a dendrimer structure with a polypeptide backbone architecture. It has been utilized in a wide variety of applications but has found significant utility in biomedical applications. PAMAM has been studied extensively due to its globular structure that is similar to proteins found in the body. The branched architecture and overall size provide a favorable environment for host-guest interactions and allows for the loading of small molecules for therapeutic delivery. Although PAMAM has many benefits for use in the area of therapeutic delivery, a primary area of concern for this molecular architecture is the terminal amines that serve …