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Development Of Pre-Clinical Assays Based On Tandem Mass Spectrometry To Investigate Gabaa Receptor Modulators, Margaret Laurel Guthrie
Development Of Pre-Clinical Assays Based On Tandem Mass Spectrometry To Investigate Gabaa Receptor Modulators, Margaret Laurel Guthrie
Theses and Dissertations
ABSTRACT
DEVELOPMENT OF PRE-CLINICAL ASSAYS BASED ON TANDEM MASS SPECTROMETRY TO INVESTIGATE GABAA RECEPTOR MODULATORS
by
Margaret L. Guthrie
The University of Wisconsin – Milwaukee, 2017
Under the Supervision of Professor Alexander (Leggy) Arnold
Drugs are compounds that interact with a biological system to produce a specific biological response. The goal of drug discovery is to design and synthesize a pharmaceutical agent that will produce a desired biological effect. However, the in-vivo effects of a drug molecule cannot be predicted without a variety of test results prior to human clinical trials. In order to designate any drug compound as a …