Physical Sciences and Mathematics Commons^™

Structure, Dynamics, And Redox Reactivity Of An All-Purpose Flavodoxin, Sharique Khan, Ahmadullah Ansari, Monica Brachi, Debarati Das, Wassim El Housseini, Shelley Minteer, Anne Frances Miller

Chemistry Faculty Research & Creative Works

The Flavodoxin Of Rhodopseudomonas Palustris CGA009 (Rp9Fld) Supplies Highly Reducing Equivalents To Crucial Enzymes Such As Hydrogenase, Especially When The Organism Is Iron-Restricted. By Acquiring Those Electrons From Photodriven Electron Flow Via The Bifurcating Electron Transfer Flavoprotein, Rp9Fld Provides Solar Power To Vital Metabolic Processes. To Understand Rp9Fld's Ability To Work With Diverse Partners, We Solved Its Crystal Structure. We Observed The Canonical Flavodoxin (Fld) Fold And Features Common To Other Long-Chain Flds But Not All The Surface Loops Thought To Recognize Partner Proteins. Moreover, Some Of The Loops Display Alternative Structures And Dynamics. To Advance Studies Of Protein–protein Associations …

Modeling The Spread Of Covid-19 In Spatio-Temporal Context, S.H. Sathish Indika, Norou Diawara, Hueiwang Anna Jeng, Bridget D. Giles, Dilini S.K. Gamage

Mathematics & Statistics Faculty Publications

This study aims to use data provided by the Virginia Department of Public Health to illustrate the changes in trends of the total cases in COVID-19 since they were first recorded in the state. Each of the 93 counties in the state has its COVID-19 dashboard to help inform decision makers and the public of spatial and temporal counts of total cases. Our analysis shows the differences in the relative spread between the counties and compares the evolution in time using Bayesian conditional autoregressive framework. The models are built under the Markov Chain Monte Carlo method and Moran spatial correlations. …

The Reversible Low-Temperature Instability Of Human Dj-1 Oxidative States, Tessa Andrews, Javier Seravallic, Robert Powers

Robert Powers Publications

DJ-1 is a homodimeric protein that is centrally involved in various human diseases including Parkinson disease (PD). DJ-1 protects against oxidative damage and mitochondrial dysfunction through a homeostatic control of reactive oxygen species (ROS). DJ-1 pathology results from a loss of function, where ROS readily oxidizes a highly conserved and functionally essential cysteine (C106). The over-oxidation of DJ-1 C106 leads to a dynamically destabilized and biologically inactivated protein. An analysis of the structural stability of DJ-1 as a function of oxidative state and temperature may provide further insights into the role the protein plays in PD progression. NMR spectroscopy, circular …

Rapidly Changing Range Limits In A Warming World: Critical Data Limitations And Knowledge Gaps For Advancing Understanding Of Mangrove Range Dynamics In The Southeastern Usa, Rémi Bardou, Michael J. Osland, Steven Scyphers, Christine Shepard, Karen E. Aerni, Jahson B. Alemu I, Robert Crimian, Richard H. Day, Nicholas M. Enwright, Laura C. Feher, Sarah L. Gibbs, Kiera O'Donnell, Savannah H. Swinea, Kalaina Thorne, Sarit Truskey, Anna R. Armitage, Ronald Baker, Josh L. Breithaupt, Kyle C. Cavanaugh, Erik S. Yando, A. Randall Hughes, Et Al.

Biological Sciences Faculty Publications

Climate change is altering species’ range limits and transforming ecosystems. For example, warming temperatures are leading to the range expansion of tropical, cold-sensitive species at the expense of their cold-tolerant counterparts. In some temperate and subtropical coastal wetlands, warming winters are enabling mangrove forest encroachment into salt marsh, which is a major regime shift that has significant ecological and societal ramifications. Here, we synthesized existing data and expert knowledge to assess the distribution of mangroves near rapidly changing range limits in the southeastern USA. We used expert elicitation to identify data limitations and highlight knowledge gaps for advancing understanding of …

Unusual High-Frequency Mechanical Properties Of Polymer-Grafted Nanoparticle Melts, Mayank Jhalaria, Yu Chang, Yucheng Huang, Brian C. Benicewicz, Sanat K. Kumar, George Fytas

Faculty Publications

Brillouin light spectroscopy is used to measure the elastic moduli of spherical polymer-grafted nanoparticle (GNP) melts as a function of chain length at fixed grafting density (0.47  chains/nm²) and nanoparticle radius (8 nm). While the moduli follow a rule of mixtures (Wood’s law) for long chains, they display enhanced elasticity and anomalous dissipation for graft chains <1⁢0⁢0  kDa. GNP melts with long polymers at high 𝜎 have a dry zone near the GNP core, surrounded by a region where the grafts can interpenetrate with chain fragments from adjacent GNPs. We propose that the departures from Wood’s law for short chains are due to the effectively larger silica volume fraction in the region where sound propagates—this is caused by the short, interpenetrated chain fragments being pushed out of the way. We thus conclude that transport mechanisms (of gas, ions, sound, thermal phonons) in GNP melts are radically different if interpenetrated chain segments can be “pushed out of the way” or not. This provides a facile new means for manipulating the properties of these materials.

In Silico Identification Of Vaccine Candidates Against Viral Infections, Prabin Baral

FIU Electronic Theses and Dissertations

There are many viral diseases without effective treatments or vaccines. These viruses can cause catastrophic epidemics such as the Lassa, Ebola, and Marburg viruses. Similarly, the recent coronavirus pandemic is of great concern as new variants are continuously emerging with decreased susceptibility to antibodies and vaccines that were developed for earlier strains. A critical step in the immune system’s fight against viruses involves an immunological protein molecule binding to a viral protein molecule. I investigate the atomic and molecular details of binding site recognition and binding interactions and dynamics for three important viruses.

Antigens are molecules, such as viral proteins, …

On The Use Of High-Frequency Surface Wave Oceanographic Research Radars As Bistatic Single-Frequency Oblique Ionospheric Sounders, Stephen R. Kaeppler, Ethan S. Miller, Daniel Cole, Teresa Updyke

CCPO Publications

We demonstrate that bistatic reception of high-frequency oceanographic radars can be used as single-frequency oblique ionospheric sounders. We develop methods that are agnostic of the software-defined radio system to estimate the group range from the bistatic observations. The group range observations are used to estimate the virtual height and equivalent vertical frequency at the midpoint of the oblique propagation path. Uncertainty estimates of the virtual height and equivalent vertical frequency are presented. We apply this analysis to observations collected from two experiments run at two locations in different years, but utilizing similar software-defined radio data collection systems. In the first …

Monitoring And Modelling The Dynamics Of The Cellular Glycolysis Pathway: A Review And Future Perspectives, Nitin Patil, Hugh Byrne, Orla L. Howe, Paul A. Cahill

Articles

Background

The dynamics of the cellular glycolysis pathway underpin cellular function and dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies. Evolving our understanding of this fundamental process and its dynamics remains critical.

Scope of review

This paper reviews the medical relevance of glycolytic pathway in depth and explores the current state of the art for monitoring and modelling the dynamics of the process. The future perspectives of label free, vibrational microspectroscopic techniques to overcome the limitations of the current approaches are considered.

Major conclusions

Vibrational microspectroscopic techniques can potentially operate in the niche area of limitations of other …

Indoor Air Quality Through The Lens Of Outdoor Atmospheric Chemistry, Jonathan P.D. Abbatt, Douglas B. Collins

Faculty Contributions to Books

Outdoor atmospheric chemistry and air quality have been the topic of research that intensified in earnest around the mid-20^th century, while indoor air quality research has only been a key focus of chemical researchers over the last 30 years. Examining practices and approaches employed in the outdoor atmospheric chemistry research enterprise provides an additional viewpoint from which we can chart new paths to increase scientific understanding of indoor chemistry. This chapter explores our understanding of primary chemical sources, homogeneous and multiphase reactivity, gas-surface partitioning, and the coupling between the chemistry and dynamics of indoor air through the lens of …

Video Snapshot: Single Image Motion Expansion Via Invertible Motion Embedding, Qianshu Zhu, Chu Han, Guoqiang Han, Tien-Tsin Wong, Shengfeng He

Research Collection School Of Computing and Information Systems

Unlike images, finding the desired video content in a large pool of videos is not easy due to the time cost of loading and watching. Most video streaming and sharing services provide the video preview function for a better browsing experience. In this paper, we aim to generate a video preview from a single image. To this end, we propose two cascaded networks, the motion embedding network and the motion expansion network. The motion embedding network aims to embed the spatio-temporal information into an embedded image, called video snapshot. On the other end, the motion expansion network is proposed to …

12 C(E,E'Pn) Measurements Of Short Range Correlations In The Tensor-To-Scalar Interaction Transition Region, I. Korover, J. R. Pybus, A. Schmidt, F. Hauenstein, M. Duer, O. Hen, E. Piasetzky, L. B. Weinstein, D. W. Higinbotham, S. Adhikari, K. Adhikari, M. J. Amaryan, Giovanni Angelini, H. Atac, L. Barion, M. Battaglieri, A. Beck, I. Bedlinkskiy, Fatiha Benmokhtar, Steffen Strauch, Ralf W. Gothe, Krishna Chandra Neupane, Et. Al.

Faculty Publications

High-momentum configurations of nucleon pairs at short-distance are probed using measurements of the C-12(e, e' p) and C-12(e, e' pN) reactions (where N is either n or p), at high-Q(2) and x(B) > 1.1. The data span a missing-momentum range of 300-1000 MeV/c and are predominantly sensitive to the transition region of the strong nuclear interaction from a Tensor to Scalar interaction. The data are well reproduced by theoretical calculations using the Generalized Contact Formalism with both chiral and phenomenological nucleon-nucleon (NN) interaction models. This agreement suggests that the measured high missing-momentum protons up to 1000 MeV/c predominantly belong to short-ranged …

An Operational Overview Of The Export Processes In The Ocean From Remote Sensing (Exports) Northeast Pacific Field Deployment, David A. Siegel, Ivona Cetinic, Jason R. Graff, Craig M. Lee, Norman Nelson, Mary Jane Perry, Inia Soto Ramos, Deborah K. Steinberg, Ken Buesseler, Roberta Hamme, Andrea J. Fassbender, David Nicholson, Melissa M. Omand, Marie Robert, Andrew Thompson, Vinicius Amaral, Michael Behrenfeld, Claudia R. Benitez-Nelson, Kelsey Bisson, Emmanuel Boss, Et. Al.

Faculty Publications

The goal of the EXport Processes in the Ocean from RemoTe Sensing (EXPORTS) field campaign is to develop a predictive understanding of the export, fate, and carbon cycle impacts of global ocean net primary production. To accomplish this goal, observations of export flux pathways, plankton community composition, food web processes, and optical, physical, and biogeochemical (BGC) properties are needed over a range of ecosystem states. Here we introduce the first EXPORTS field deployment to Ocean Station Papa in the Northeast Pacific Ocean during summer of 2018, providing context for other papers in this special collection. The experiment was conducted with …

¹² C(E,E'Pn) Measurements Of Short Range Correlations In The Tensor-To-Scalar Interaction Transition Region, I. Korover, J. R. Pybus, A. Schmidt, F. Hauenstein, M. Duer, L. B. Weinstein, M. J. Amaryan, D. Bullumulla, M. Hattawy, X. Zheng, Et Al., The Clas Collaboration

Physics Faculty Publications

High-momentum configurations of nucleon pairs at short-distance are probed using measurements of the ¹²C(e,'p) and ¹²C (e,e'pN) reactions (where N is either n or p), at high Q² and 𝒙_B > 1.1. The data span a missing-momentum range of 300-1000 MeV/c and are predominantly sensitive to the transition region of the strong nuclear interaction from a tensor to scalar interaction. The data are well reproduced by theoretical calculations using the generalized contact formalism with both chiral and phenomenological nucleon-nucleon (NN) interaction models. This agreement suggests that the measured high missing-momentum protons up to 1000 MeV/c predominantly …

Multi-User Verifiable Searchable Symmetric Encryption For Cloud Storage, Xueqiao Liu, Guomin Yang, Guomin Yang

Research Collection School Of Computing and Information Systems

In a cloud data storage system, symmetric key encryption is usually used to encrypt files due to its high efficiency. In order allow the untrusted/semi-trusted cloud storage server to perform searching over encrypted data while maintaining data confidentiality, searchable symmetric encryption (SSE) has been proposed. In a typical SSE scheme, a users stores encrypted files on a cloud storage server and later can retrieve the encrypted files containing specific keywords. The basic security requirement of SSE is that the cloud server learns no information about the files or the keywords during the searching process. Some SSE schemes also offer additional …

Wallaby – An Ska Pathfinder H I Survey, Bärbel S. Koribalski, L. Staveley-Smith, T. Westmeier, P. Serra, K. Spekkens, O. I. Wong, K. Lee-Waddell, C. D.P. Lagos, D. Obreschkow, E. V. Ryan-Weber, M. Zwaan, V. Kilborn, G. Bekiaris, K. Bekki, F. Bigiel, A. Boselli, A. Bosma, B. Catinella, G. Chauhan, M. E. Cluver, M. Colless, H. M. Courtois, R. A. Crain, W. J.G. De Blok, H. Dénes, A. R. Duffy, A. Elagali, C. J. Fluke, B. Q. For, G. Heald, P. A. Henning, K. M. Hess, Benne W. Holwerda

Faculty Scholarship

The Widefield ASKAP L-band Legacy All-sky Blind surveY (wallaby) is a next-generation survey of neutral hydrogen (H i) in the Local Universe. It uses the widefield, high-resolution capability of the Australian Square Kilometer Array Pathfinder (ASKAP), a radio interferometer consisting of 36 × 12 -m dishes equipped with Phased-Array Feeds (PAFs), located in an extremely radio-quiet zone in Western Australia. wallaby aims to survey three-quarters of the sky (− 90 ∘< δ< + 30 ∘) to a redshift of z≲ 0.26 , and generate spectral line image cubes at ∼30 arcsec resolution and ∼1.6 mJy beam−1 per 4 km s−1 channel sensitivity. ASKAP’s instantaneous field of view at 1.4 GHz, delivered by the PAF’s 36 beams, is about 30 sq deg. At an integrated signal-to-noise ratio of five, wallaby is expected to detect around half a million galaxies with a mean redshift of z∼ 0.05 (∼200 Mpc). The scientific goals of wallaby include: (a) a census of gas-rich galaxies in the vicinity of the Local Group; (b) a study of the H i properties of galaxies, groups and clusters, in particular the influence of the environment on galaxy evolution; and (c) the refinement of cosmological parameters using the spatial and redshift distribution of low-bias gas-rich galaxies. For context we provide an overview of recent and planned large-scale H i surveys. Combined with existing and new multi-wavelength sky surveys, wallaby will enable an exciting new generation of panchromatic studies of the Local Universe. — First results from the wallaby pilot survey are revealed, with initial data products publicly available in the CSIRO ASKAP Science Data Archive (CASDA).

Soil Labile Organic Carbon Fractions And Soil Enzyme Activities After 10 Years Of Continuous Fertilization And Wheat Residue Incorporation, Ligan Zhang, Xi Chen, Yujun Xu, Mengcan Jin, Xinxin Ye, Hongjian Gao, Wenying Chu, Jingdong Mao, Michael L. Thompson

Chemistry & Biochemistry Faculty Publications

Labile organic carbon (LOC) fractions and related enzyme activities in soils are considered to be early and sensitive indicators of soil quality changes. We investigated the influences of fertilization and residue incorporation on LOC fractions, enzyme activities, and the carbon pool management index (CPMI) in a 10-year field experiment. The experiment was composed of three treatments: (1) no fertilization (control), (2) chemical fertilizer application alone (F), and (3) chemical fertilizer application combined with incorporation of wheat straw residues (F + R). Generally, the F + R treatment led to the highest concentrations of the LOC fractions. Compared to the control …

Characterizing Complexity In A Semiconductor With Optical Feedback From Two Mirrors, Layla M. Abrams

2020 Symposium Posters

Lasers are stable devices with a broad spectrum of applications. They can be perturbed to induce complex dynamics in their output intensity. One interesting regime in semiconductor lasers is that the output intensity of the laser emits a sequence of non-regular optical spikes. This behavior resembles that of neurons. We use a semiconductor laser with optical feedback from two mirrors to characterize the behavior of the laser's power output. The data is then analyzed by transforming the intensity time series into a sequence of patterns or words. By doing this we want to explore how the laser changes its preferred …

Comparing Proton Momentum Distributions In A = 2 And 3 Nuclei Via 2H 3H And 3He (E,E′P) Measurements, R. Cruz-Torres, F. Hauenstein, A. Schmidt, D. Nguyen, D. Abrams, H. Albataineh, S. Alsalmi, D. Androic, K. Aniol, W. Armstrong, J. Arrington, H. Atac, D. Bulumulla, C. E. Hyde, V. Khachatryan, M. N.H. Rashad, L. B. Weinstein, Z. Y. Ye, J. Zhang, Jefferson Lab Hall A Tritium Collaboration

Physics Faculty Publications

We report the first measurement of the (e, e' p) reaction cross-section ratios for Helium-3 (³He), Tritium (³H), and Deuterium (d). The measurement covered a missing momentum range of 40 ≤ p_miss ≤ 550 MeV/c, at large momentum transfer ({Q²} ≈ 1.9 (GeV/c)²) and x_B > 1, which minimized contributions from non quasi-elastic (QE) reaction mechanisms. The data is compared with planewave impulse approximation (PWIA) calculations using realistic spectral functions and momentum distributions. The measured and PWIA-calculated cross-section ratios for ³He/d and ³H/d extend to just above the typical …

Muon Capture In Nuclei: An Ab Initio Approach Based On Green's Function Monte Carlo Methods, A. Lovato, N. Rocco, Rocco Schiavilla

Physics Faculty Publications

An ab initio Green’s function Monte Carlo (GFMC) method is introduced for calculating total rates of muon weak capture in light nuclei with mass number A ≤ 12. As a first application of the method, we perform a calculation of the rate in ³H and ⁴He in a dynamical framework based on realistic two- and three-nucleon interactions and realistic nuclear charge-changing weak currents. The currents include one- and two-body terms induced by π-and ρ-meson exchange, and N-to-Δ excitation, and are constrained to reproduce the empirical value of the Gamow-Teller matrix element in tritium. We investigate the sensitivity of …

Distributary Channel Networks As Moving Boundaries: Causes And Morphodynamic Effects, Robert C. Mahon, John B. Shaw, Wun-Tao Ke, Christopher A. Cathcart

Earth and Environmental Sciences Faculty Publications

We propose an exploratory model to describe the morphodynamics of distributary channel network growth on river deltas. The interface between deep channels and the shallow, unchannelized delta front deposits is modeled as a moving boundary. Steady flow over the unchannelized delta front is friction dominated and modeled by Laplace's equation. Shear stress along the network boundary produces nonlinear erosion rates at the interface, causing the boundary to move and network elements (channels and branches) to form. The model was run for boundary conditions resembling the Wax Lake Delta in coastal Louisiana, 20 parameterizations of sediment transport, and 3 …

Water Entry Of Spheres At Various Contact Angles, Nathan B. Spiers, Mohammad M. Mansoor, Jesse Belden, Tadd T. Truscott

Mechanical and Aerospace Engineering Faculty Publications

It is well known that the water entry of a sphere causes cavity formation above a critical impact velocity as a function of the solid-liquid contact angle (Duez et al. 2007). Using a rough sphere with a contact angle of 120^◦, Aristoff & Bush (2009) showed that there are four different cavity shapes dependent on the Bond and Weber numbers (i.e., quasi-static, shallow, deep and surface). We experimentally alter the Bond number, Weber number and contact angle of smooth spheres and find two key additions to the literature: 1) Cavity shape also depends on the contact angle; 2) …

Sponges Structure Water-Column Characteristics In Shallow Tropical Coastal Ecosystems, Marla M. Valentine, Mark J. Butler Iv

Biological Sciences Faculty Publications

Sponges can have powerful effects on ecosystem processes in shallow tropical marine ecosystems. They drive benthic-pelagic coupling by filtering dissolved and particulate organic matter from the water column, alter water chemistry in association with their symbiotic microorganisms, and increase habitat structural complexity. Anthropogenic degradation of coastal waters is widespread and can reduce the density and diversity of foundation species such as sponges, potentially diminishing their contributions to ecosystem processes. We used a novel mesocosm design that minimized artifacts associated with traditional single-species and closed-system filtration experiments to examine the effects of water turnover and sponge biomass on water-column properties. Using …

Instability Of Flux Flow And Production Of Vortex-Antivortex Pairs By Current-Driven Josephson Vortices In Layered Superconductors, Ahmad Sheikhzada, Alex Gurevich

Physics Faculty Publications

We report numerical simulations of the nonlinear dynamics of Josephson vortices driven by strong dc currents in layered superconductors. Dynamic equations for interlayer phase differences in a stack of coupled superconducting layers were solved to calculate a drag coefficient η(J) of the vortex as a function of the perpendicular dc current density J. It is shown that Cherenkov radiation produced by a moving vortex causes significant radiation drag increasing η(v) at high vortex velocities v and striking instabilities of driven Josephson vortices moving faster than a terminal v_c. The steady-state flux flow breaks down at ν > v …

Current-Driven Production Of Vortex-Antivortex Pairs In Planar Josephson Junction Arrays And Phase Cracks In Long-Range Order, Francisco Estellés-Duart, Miguel Ortuño, Andrés M. Somoza, Valerii M. Vinokur, Alex Gurevich

Physics Faculty Publications

Proliferation of topological defects like vortices and dislocations plays a key role in the physics of systems with long-range order, particularly, superconductivity and superfluidity in thin films, plasticity of solids, and melting of atomic monolayers. Topological defects are characterized by their topological charge reflecting fundamental symmetries and conservation laws of the system. Conservation of topological charge manifests itself in extreme stability of static topological defects because destruction of a single defect requires overcoming a huge energy barrier proportional to the system size. However, the stability of driven topological defects remains largely unexplored. Here we address this issue and investigate numerically …

Catalysis Of Stark-Tuned Interactions Between Ultracold Rydberg Atoms, A. L. Win, W. D. Williams, T. J. Carroll, C. I. Sukenik

Physics Faculty Publications

We have experimentally investigated a catalysis effect in the resonant energy transfer between ultracold ⁸⁵Rb Rydberg atoms. We studied the time dependence of the process, 34p + 34p → 34s + 35s, and observed an enhancement of 34s state population when 34d state atoms are added. We have also performed numerical model simulations, which are in qualitative agreement with experiment and indicate that the enhancement arises from a redistribution of p-state atoms due to the presence of the d-state atoms.

Scalable, Hydrophobic And Highly-Stretchable Poly(Isocyanurate-Urethane) Aerogels, Sadeq Malakooti, Saman Rostami, Habel Gitogo Churu, Huiyang Luo, Jenna Clark, Fabiola Casarez, Owen Rettenmaier, Soheil Daryadel, Majid Minary-Jolandan, Chariklia Sotiriou-Leventis, Nicholas Leventis, Hongbing Lu

Chemistry Faculty Research & Creative Works

Scalable, low-density and flexible aerogels offer a unique combination of excellent mechanical properties and scalable manufacturability. Herein, we report the fabrication of a family of low-density, ambient-dried and hydrophobic poly(isocyanurate-urethane) aerogels derived from a triisocyanate precursor. The bulk densities ranged from 0.28 to 0.37 g cm^-3 with porosities above 70% v/v. The aerogels exhibit a highly stretchable behavior with a rapid increase in the Young's modulus with bulk density (slope of log-log plot > 6.0). In addition, the aerogels are very compressible (more than 80% compressive strain) with high shape recovery rate (more than 80% recovery in 30 s). Under …

The Effect Of Warmer Winters On The Demography Of An Outbreak Insect Is Hidden By Intraspecific Competition, Devin W. Goodsman, Guenchik Grosklos, Brian H. Aukema, Caroline Whitehouse, Katherine P. Bleiker, Nate G. Mcdowell, Richard S. Middleton, Chonggang Xu

Mathematics and Statistics Faculty Publications

Warmer climates are predicted to increase bark beetle outbreak frequency, severity, and range. Even in favorable climates, however, outbreaks can decelerate due to resource limitation, which necessitates the inclusion of competition for limited resources in analyses of climatic effects on populations. We evaluated several hypotheses of how climate impacts mountain pine beetle reproduction using an extensive 9‐year dataset, in which nearly 10,000 trees were sampled across a region of approximately 90,000 km², that was recently invaded by the mountain pine beetle in Alberta, Canada. Our analysis supports the hypothesis of a positive effect of warmer winter temperatures on …

Bioinformatic And Biophysical Analyses Of Proteins, Jonathan Catazaro

Department of Chemistry: Dissertations, Theses, and Student Research

The prevailing dogma in structural genomics is the existence of a strong correlation between protein sequence, structure, and biological function. Proteins with high sequence similarity typically have a similar, if not the same, structure and function. In many cases this logic can fail due to distantly related proteins having very low sequence similarity, a lack of a representative structure, structural novelty, or the absence of a characterized function. Further, the paradigm fails to account for dynamics, which have a significant effect on structural stability and enzymatic efficacy.

Nuclear magnetic resonance (NMR) spectroscopy is uniquely capable of solving the structure, assisting …

Urban Foraging: A Ubiquitous Human Practice Overlooked By Urban Planners, Policy, And Research, Charlie M. Shackleton, Patrick T. Hurley, Annika C. Dahlberg, Marla R. Emery, Harini Nagendra

Environment and Sustainability Faculty Publications

Although hardly noticed or formally recognized, urban foraging by humans probably occurs in all urban settings around the world. We draw from research in India, South Africa, Sweden, and the United States to demonstrate the ubiquity and varied nature of urban foraging in different contexts. Across these different contexts, we distill seven themes that characterize and thereby advance thinking about research and the understanding of urban foraging. We show that it is widespread and occurs across a variety of urban spaces and places. The species used and the local practices vary between contexts, and are in constant flux as urban …

Sma Observations Of The Hot Molecular Core Iras 18566+0408, Andrea Silva, Qizhou Zhang, Patricio Sanhueza, Xing Lu, Maria T. Beltran, Cassandra Fallscheer, Henrik Beuther, T. K. Sridharan, Riccardo Cesaroni

All Faculty Scholarship for the College of the Sciences

We present Submillimeter Array (SMA) observations toward the high-mass star-forming region IRAS 18566+0408. Observations at the 1.3 mm continuum and in several molecular line transitions were performed in the compact (2ʺ4 angular resolution) and very-extended (~0ʺ4 angular resolution) configurations. The continuum emission from the compact configuration shows a dust core of 150 M _⊙, while the very-extended configuration reveals a dense (2.6 × 10⁷ cm⁻³) and compact (~4000 au) condensation of 8 M _⊙. We detect 31 molecular transitions from 14 species including CO isotopologues, SO, CH₃OH, OCS, and CH₃CN. Using …