Physical Sciences and Mathematics Commons^™

Characterization And Reaction Of An Analog Of The Anticancer Drug Oxaliplatin, Jonathan D. Hendrie

Mahurin Honors College Capstone Experience/Thesis Projects

Oxaliplatin is an anticancer drug that reacts with DNA, RNA, and proteins both in vitro and in vivo. Our research focuses on synthesizing analogs of oxaliplatin and understanding how bulky ligand groups affect reaction with amino acids. (R,R)-N,N’-dimethyl-1,2-diaminocyclohexane platinum(II) oxalate or Pt(Me2dach)(ox) varies from oxaliplatin or Pt(dach)(ox) in that it has one methyl group attached to each platinum coordinated nitrogen. Nuclear Magnetic Resonance (NMR) spectroscopy has shown that the reactions of N-Acetylmethionine (N-AcMet) with Pt(Me2dach)(ox) and Pt(dach)(ox) proceed at similar rates suggesting that the methyl groups of Pt(Me2dach)(ox) have little effect on the initial reaction. Whereas the reaction of Pt(dach)(ox) …

Keeney, Sean Carpenter (Sc 1259), Manuscripts & Folklife Archives

MSS Finding Aids

Finding aid only for Manuscripts Small Collection 1259. “My Experience of ‘Andrew,’” by Sean Keeney, Dade County, Florida, relating the effect on him and his family of Hurricane Andrew, which struck the area on 24 August 1992. Includes biographical data on Keeney.

The Effects Of Standards-Based Grading On Student Performance In Algebra 2, Rachel Beth Rosales

Dissertations

The use of standards-based grading in American public schools is increasing, offering students, parents, and teachers a new way of measuring and communicating about student achievement and performance. Parents indicate an appreciation for this method of grading, and students at the elementary grades (K-6) have improved standardized test scores in reading and math as a result of its implementation. This study seeks to determine whether standards-based grading has the same effect on students at the high school level (grades 9-12) by comparing end-of-course test scores and posttest scores of Algebra 2 students enrolled in a standards-based graded classroom with to …

Ogden College Of Science & Engineering Newsletter (Winter 2013), Cheryl Stevens, Dean

Ogden College of Science & Engineering Publications

No abstract provided.

Global Digital Elevation Model Accuracy Assessment In The Himalaya, Nepal, Luke G. Miles

Masters Theses & Specialist Projects

Digital Elevation Models (DEMs) are digital representations of surface topography or terrain. Collection of DEM data can be done directly through surveying and taking ground control point (GCP) data in the field or indirectly with remote sensing using a variety of techniques. The accuracies of DEM data can be problematic, especially in rugged terrain or when differing data acquisition techniques are combined. For the present study, ground data were taken in various protected areas in the mountainous regions of Nepal. Elevation, slope, and aspect were measured at nearly 2000 locations. These ground data were imported into a Geographic Information System …

Interactive Wireless Sensor For Remote Trace Detection And Recognition Of Hazardous Gases, Audrey Lama

Masters Theses & Specialist Projects

The interactive wireless sensor detects many hazardous gases such as Hexane, Propane, Carbon monoxide and Hydrogen. These gases are highly toxic and used in different kinds of manufacturing industries, domestic purpose and so on. So, building a sensor that can detect this kind of gases can save the environment; prevent the potential for explosion, and endangering human life. In long term, interactive wireless sensor can also prevent the financial losses that might occur due to the hazardous incident that might occur due to these toxic gases.

Hexane is a colorless, strong gas which inhaled in significant amounts by a person …

Sources Of Co2 Controlling The Carbonate Chemistry Of The Logsdon River, Mammoth Cave, Kentucky, Bruce Elliott Hatcher

Masters Theses & Specialist Projects

Logsdon River is a major, base-level stream within the Turnhole Bend Drainage basin of the Mammoth Cave System. The Logsdon River system has provided a unique opportunity to examine the geochemical evolution of a stream flowing through a major karst conduit that can be traversed for 10 km. This study examines CO₂ inputs at the upstream portion of the river, which provide major control for the river’s hydrochemistry. Samples were collected from the upstream portion of Logsdon River at what is referred to as the S-188 sump and also nearby at Crowbar Dome over the course of 44 weeks …

Eastern Deciduous Forest Phenology And Vegetative Vigor Trends From 2000 To 2013, Mammoth Cave National Park, Ky, Sean Taylor Hutchison

Masters Theses & Specialist Projects

Global climate change is predicted to affect environmental systems at the midlatitudes, but the scope, severity, and outcomes of these impacts are yet to be fully understood. This study focuses on the implications of short-term climate variability for forests in central Kentucky. Using a Normalized Difference Vegetation Index (NDVI) calculated from MODerate-Resolution Imaging Spectroradiometer (MODIS) instrument data, the photosynthetic activity of vegetation at Mammoth Cave National Park (MACA) is tracked from 2000 to 2013. Three methods were employed to examine the changes and climate influences in vegetation over the study period: 1) aggregating the NDVI of the Park by year …

Molecular Level Interaction Of Human Fibroblast Growth Factor-1 (Hfgf-1) With Phloridzin, Rammohan Paripelly

Masters Theses & Specialist Projects

Fibroblast growth factors (FGFs) are a family of growth factors which includes twenty three proteins. FGFs work as modulators for various cellular activities like mitosis, differentiation and survival. Among the FGF family, human fibroblast growth factor-1 (hFGF-1), which is also known as acidic fibroblast growth factor, is a potent angiogenic agent, involved in the formation of new blood vessels in various tissues. hFGF-1 is regarded as a prototype of the FGF family. It serves as one of the potential targets in tumor inhibition and obesity due to its involvement in new blood vessel formation in cancerous regions and adipose tissues. …

Solar Energy Conversion And Control Using Organic Photovoltaic Cells, Kurt Wade Woods

Masters Theses & Specialist Projects

Organic photovoltaic (OPV) cells are advanced, newly emerging technologies that are lightweight, mechanically flexible devices with highthroughput processes from low cost material in a variety of colors. Rathnayake et al. of Western Kentucky University have developed a nanostructure-based OPV cell. Presented in this thesis is a model and simulation of a generalized PV powered system that can predict the performance of solar arrays in various environmental conditions. The simulation has been carried out in Matlab/Simulink, and upon entering the cell’s parameters, it provides key electrical characteristics such as the cell’s I-V curve and efficiency information. The total system that is …

Synthesis And Characterization Of Manganese Pyridazyl Complexes, Sana Shah

Masters Theses & Specialist Projects

Heterocyclic’s and their fused-ring derivatives have been of interest for their use in electronic materials due to their ease of production, synthetic versatility, and low cost compared to traditional inorganic materials like silicon. Pyridazines have been found to be useful in catalysis gas storage, polymeric sensors and biological mimetics. When a transition-metal is fused into a synthesized pyridazine, unique properties such as conductivity and optics are allowed. In this work, synthesized pyridazine complexes will be analyzed by mass spectroscopy, elemental analysis, nuclear magnetic resonance, imaging, x-ray crystallography, and infrared spectroscopy. We are interested in synthesizing organometallic pyridazines and manganese pyridazyl …

Synthesis And Structures Of New Three-Dimensional Copper Metal-Organic Frameworks, Nitin Kumar Pally

Masters Theses & Specialist Projects

Metal-organic frameworks (MOFs) are crystalline materials with metal ions covalently bonded to organic ligands. The ligands act as spacers often creating a porous structure with very high pore volume and surface area. MOFs are known for their robust structures, high porosity, and different chemical functionalities and are considered for applications in adsorptions, separations, catalysis and gas storage. This work focuses on the synthesis of new MOFs using copper compounds. Different types of carboxylate ligands were used for the synthesis. Two new copper-organic frameworks, [Cu₃(pyz)(btc)] (1), and [(Cu₃(btc))•xH₂O] (2) (btc= benzene-1,3,5-tricarboxylate, pyz= pyrazine) have been …

Leslie Matrices For Logistic Population Modeling, Bruce Kessler

Mathematics Faculty Publications

Leslie matrices are taught as a method of modeling populations in a discrete-time fashion with more detail in the tracking of age groups within the population. Leslie matrices have limited use in the actual modeling of populations, since when the age groups are summed, it is basically equivalent to discrete-time modeling assuming exponential population growth. The logistic model of population growth is more realistic, since it takes into account a carrying capacity for the environment of the population. This talk will describe an adjustment to the Leslie matrix approach for population modeling that is both takes into account the carrying …

The Western Kentucky University Crumps Cave Research & Education Preserve, Chris Groves, Jason Polk, Ben Miller, Pat Kambesis, Carl Bolster, Sean Vanderhoff, Beth Tyrie

Earth, Environmental, and Atmospheric Sciences Faculty Publications

Crumps Cave is located about one kilometer northeast of Smiths Grove, Kentucky (Figures 1, 2, and 3). The only known entrance was purchased by Western Kentucky University (WKU) in 2009 through a grant from the Kentucky Heritage Land Conservation Fund and the cave is managed as the focal point of a research and education preserve to study a wide range of environmental conditions and dynamics, and their interactions, using high-resolution electronic monitoring along with geochemical sampling, analysis and modeling. Crews from WKU’s Hoffman Environmental Research Institute visit the cave weekly for sampling, data downloading, and equipment maintenance, with a major …

Wallace And Incipient Structures: A World Of "More Recondite" Influences, Charles H. Smith

DLPS Faculty Publications

Alfred Russel Wallace is well-known for his co-discovery of the principle of natural selection. Natural selection is usually considered a process, but it is not clear that Wallace regarded it in exactly these terms. In fact he more likely thought of the relationships involved as representing what we would now term a “state space,” a negative feedback loop wherein populations are maintained at healthy levels through elimination of the unfit. Both before and after the advent of natural selection Wallace clung to the idea that “more recondite forces” were shaping the nature and direction of evolution; this is especially evident …

Disher, John Lee, 1938-2019 (Sc 1183), Manuscripts & Folklife Archives

MSS Finding Aids

Finding aid only for Manuscripts Small Collection 1183. Letter from John Lee Disher of Summerville, South Carolina, to his sister Nancy Disher Baird, Bowling Green, Kentucky, describing the aftermath of Hurricane Hugo.

Geogram 2013, David J. Keeling Editor, Wku Department Of Geography And Geology

Earth, Environmental, and Atmospheric Sciences Publications

No abstract provided.

Cox, Brittany (Fa 763), Manuscripts & Folklife Archives

FA Finding Aids

Finding aid only for Folklife Archives Project 763. Paper titled “Haunted Places in Brandenburg, Kentucky” written by Brittany Cox for a folk studies class at Western Kentucky University. Paper includes information about haunted locations in Brandenburg, Meade County, Kentucky.

Ogden College Of Science & Engineering Newsletter (Fall 2013), Cheryl Stevens, Dean

Ogden College of Science & Engineering Publications

No abstract provided.

Peaklet Analysis: Software For Spectrum Analysis, Bruce Kessler

Mathematics Faculty Publications

This is the presentation I was invited to give at the Kentucky Innovation and Entrepreneurship Conference, regarding the software that I have developed and worked at commercializing with the help of Kentucky Science and Technology Corporation.

Carbon And Oxygen Isotope Study Of Carbonates From Watling's Blue Hole And Blue Hole Five, San Salvador, Bahamas, Elaine D. Flynn

Mahurin Honors College Capstone Experience/Thesis Projects

Carbonate platforms, such as the Bahamas, formed through deposition and sea level fluctuations. These platforms contain records of rapid interglacial climate change and are useful in studying the impacts of climate change on similar tropical carbonate environments. Blue holes are dissolution lakes that may be beneficial for understanding climate change and anthropogenic impact. A δ¹³C and δ¹⁸O study was conducted on lake sediment core samples from Watling’s Blue Hole and Blue Hole Five on San Salvador Island, Bahamas. These lakes are located in a failed housing development and Watling’s Blue Hole was once part of an …

Four-Sided Boundary Problem For Two-Dimensional Random Walks, Miky Wright

Mahurin Honors College Capstone Experience/Thesis Projects

Within the four-sided boundaries of x = 0, y = 0, x = m and, y = n, a two-dimensional random walk begins at integer-valued coordinates (h,k) and moves one unit on each step either up, down, left, or right with non-zero probabilities that sum to 1. The process stops when hitting a boundary. Let P(U), P(D), P(L) and P(R) be the probabilities of hitting the upper, the lower, the left, and the right boundary first, respectively, when starting from a specific initial point within the boundaries. We use a Markov-Chain method to compute these probabilities. Let …

Long-Wave Model For Strongly Anisotropic Growth Of A Crystal Step, Mikhail Khenner

Mathematics Faculty Publications

A continuum model for the dynamics of a single step with the strongly anisotropic line energy is formulated and analyzed. The step grows by attachment of adatoms from the lower terrace, onto which atoms adsorb from a vapor phase or from a molecular beam, and the desorption is nonnegligible (the “one-sided” model). Via a multiscale expansion, we derived a long-wave, strongly nonlinear, and strongly anisotropic evolution PDE for the step profile. Written in terms of the step slope, the PDE can be represented in a form similar to a convective Cahn-Hilliard equation. We performed the linear stability analysis and computed …

The Use Of The Ostracode Cyprideis Americana (Sharpe) As A Proxy For Salinity In Bahamian Lake Systems, Rachel E. Bowles

Masters Theses & Specialist Projects

Ostracodes, bi-valved crustaceans, are potentially excellent proxies for salinity.They are abundant, react to changes in salinity, and secrete low-magnesium calcite shells that preserve information about their host water chemistry. Changes in valve trace element concentration, stable isotope composition, and sieve pore shape values have been linked to changes in salinity. This study analyzed the response of the euryhaline ostracode, Cyprideis americana, to salinity in six lakes from two Bahamian islands across two seasons. The purpose of this work was to determine which compositional and morphological variables in C. americana are the most useful for paleosalinity reconstructions.Ostracode and water samples were …

Has Safeer Improved Sacm's Work And Helped Saudi Students In The Usa Resolve Their Needs Quickly, Faisal M. Alzomily

Masters Theses & Specialist Projects

This study examined efficiency of the Safeer by gathering and analyzing the perception of 131 Saudi students from Bowling Green, KY. The purpose of the study was to ensure that the system is able to perform its function as the bridge between different institutions and Saudi students studying in the US who require assistance in processing their academic requirements. A self-administered survey using five scale points was employed. Results were summarized using descriptive statistics at 95% confidence level. The result confirmed the hypothesis that the use of the Safeer program provides quality service delivery within SACM, which in turn benefits …

Experimental Studies Of Android App Development For Smart Chess Board System, Srujan Gopu

Masters Theses & Specialist Projects

Playing chess on a smart phone has gained popularity in the last few years, offering the convenience of correspondence play, automatic recording of a game, etc. Although a good number of players love playing chess on a tablet/smart phone, it doesn't come close to the experience of playing over the traditional board. The feel and pleasure are more real when playing face down with the opponent sitting across each other rather than playing in mobile devices. This is especially true during chess tournaments. It would be ideal to enhance the experience of playing chess on board with the features of …

Single Step Synthesis Of Antibiotic Kanamycin Embedded Gold Nanoparticles For Efficient Antibacterial Activity, Shravan Gavva

Masters Theses & Specialist Projects

Nanotechnology has become the most advanced type of drug delivery system within the last decade. This advancement shifted the focus on small carriers to increase the efficiency of the drugs. Among these, gold nanoparticles (GNPs) were found to have profound biomedical applications. In current research, kanamycin embedded GNPs were prepared in a single step, single phase, and bio-friendly (green synthesis) procedure. The synthesized Kanamycin-GNPs (Kan-GNPs) were spherical in shape and had a size range of 15 ± 3 nm. The chosen kanamycin is an aminoglycosidic antibiotic that is isolated from Streptomyces kanamyceticus. These special antibiotic GNPs are further characterized using …

Late Holocene Paleoenvironmental Reconstruction In Barbados, Gilman Reno Ouellette

Masters Theses & Specialist Projects

Barbados is the easternmost island in the Caribbean region, and is uniquely situated between the Atlantic Ocean and Caribbean Sea. Being an isolated island with a karstified aquifer providing the majority of the nation’s water resources, Barbados has found itself in water scarce situations in recent years. In order to better understand natural shifts in groundwater recharge (which is determined by shifts in precipitation), longer records of precipitation are needed than are available from modern measurements. This study presents a paleoclimate reconstruction for the late Holocene on Barbados using stable and radiogenic isotope ratios in speleothem lamina as proxies. In …

Development Of Colloid Displacement Lithography Platforms For Sensor Applications, Mahesh Thugu

Masters Theses & Specialist Projects

In this work, Poly (diallyldimethylammonium) chloride - (PDDA) was used as a base layer for developing colloid displacement lithography platforms for sensor applications. Previous work shows that glass coated with PDDA and exposed to gold acts as a good platform for colloid displacement lithography. However, for actual sensor applications, electrical isolation of individual sensor sections must be achieved. This is attempted by laying down a 40 μm stripe of PDDA on a cleaned substrate and coating that stripe with gold colloid. The size of 40 μm or less in width is set as the target to fit within the scan …

Reinventing Aromatic Substitution: A Novel Look, Quang Nguyen

Masters Theses & Specialist Projects

Electrophilic aromatic substitution (EAS) and directed ortho-metalation (DoM) involve the direct substitution of an arene hydrogen. A major drawback involving EAS is the necessity for harsh forcing conditions for the reaction to proceed. Catalysts such as Lewis acids FeBr₃ and AICI₃ for the introduction of halogens and acyl groups, respectively, are each highly toxic and corrosive. Textbook preparations of aryl iodides classicaly involved the use of iodine and nitric acid. This approach affords only modest yields and does not provide regiospecific substitution of most substituted aromatics because most contain ortho/para directors which afford mixtures of …