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Full-Text Articles in Physical Sciences and Mathematics

Image De‑Photobombing Benchmark, Vatsa S. Patel, Kunal Agrawal, Samah Baraheem, Amira Yousif, Tam Nguyen Apr 2024

Image De‑Photobombing Benchmark, Vatsa S. Patel, Kunal Agrawal, Samah Baraheem, Amira Yousif, Tam Nguyen

Computer Science Faculty Publications

Removing photobombing elements from images is a challenging task that requires sophisticated image inpainting techniques. Despite the availability of various methods, their effectiveness depends on the complexity of the image and the nature of the distracting element. To address this issue, we conducted a benchmark study to evaluate 10 state-of-the-art photobombing removal methods on a dataset of over 300 images. Our study focused on identifying the most effective image inpainting techniques for removing unwanted regions from images. We annotated the photobombed regions that require removal and evaluated the performance of each method using peak signal-to-noise ratio (PSNR), structural similarity index …


Cardiogpt: An Ecg Interpretation Generation Model, Guohua Fu, Jianwei Zheng, Islam Abudayyeh, Chizobam Ani, Cyril Rakovski, Louis Ehwerhemuepha, Hongxia Lu, Yongjuan Guo, Shenglin Liu, Huimin Chu, Bing Yang Apr 2024

Cardiogpt: An Ecg Interpretation Generation Model, Guohua Fu, Jianwei Zheng, Islam Abudayyeh, Chizobam Ani, Cyril Rakovski, Louis Ehwerhemuepha, Hongxia Lu, Yongjuan Guo, Shenglin Liu, Huimin Chu, Bing Yang

Mathematics, Physics, and Computer Science Faculty Articles and Research

Numerous supervised learning models aimed at classifying 12-lead electrocardiograms into different groups have shown impressive performance by utilizing deep learning algorithms. However, few studies are dedicated to applying the Generative Pre-trained Transformer (GPT) model in interpreting electrocardiogram (ECG) using natural language. Thus, we are pioneering the exploration of this uncharted territory by employing the CardioGPT model to tackle this challenge. We used a dataset of ECGs (standard 10s, 12-channel format) from adult patients, with 60 distinct rhythms or conduction abnormalities annotated by board-certified, actively practicing cardiologists. The ECGs were collected from The First Affiliated Hospital of Ningbo University and Shanghai …


Parallelized Quadtrees For Image Compression In Cuda And Mpi, Aidan Jones Apr 2024

Parallelized Quadtrees For Image Compression In Cuda And Mpi, Aidan Jones

Senior Honors Theses

Quadtrees are a data structure that lend themselves well to image compression due to their ability to recursively decompose 2-dimensional space. Image compression algorithms that use quadtrees should be simple to parallelize; however, current image compression algorithms that use quadtrees rarely use parallel algorithms. An existing program to compress images using quadtrees was upgraded to use GPU acceleration with CUDA but experienced an average slowdown by a factor of 18 to 42. Another parallelization attempt utilized MPI to process contiguous chunks of an image in parallel and experienced an average speedup by a factor of 1.5 to 3.7 compared to …


Piecing Together Performance: Collaborative, Participatory Research-Through-Design For Better Diversity In Games, Daniel L. Gardner, Louanne Boyd, Reginald T. Gardner Jan 2024

Piecing Together Performance: Collaborative, Participatory Research-Through-Design For Better Diversity In Games, Daniel L. Gardner, Louanne Boyd, Reginald T. Gardner

Engineering Faculty Articles and Research

Digital games are a multi-billion-dollar industry whose production and consumption extend globally. Representation in games is an increasingly important topic. As those who create and consume the medium grow ever more diverse, it is essential that player or user-experience research, usability, and any consideration of how people interface with their technology is exercised through inclusive and intersectional lenses. Previous research has identified how character configuration interfaces preface white-male defaults [39, 40, 67]. This study relies on 1-on-1 play-interviews where diverse participants attempt to create “themselves” in a series of games and on group design activities to explore how participants may …


Predicting An Optimal Medication/Prescription Regimen For Patient Discordant Chronic Comorbidities Using Multi-Output Models, Ichchha Pradeep Sharma, Tam Nguyen, Shruti Ajay Singh, Tom Ongwere Jan 2024

Predicting An Optimal Medication/Prescription Regimen For Patient Discordant Chronic Comorbidities Using Multi-Output Models, Ichchha Pradeep Sharma, Tam Nguyen, Shruti Ajay Singh, Tom Ongwere

Computer Science Faculty Publications

This paper focuses on addressing the complex healthcare needs of patients struggling with discordant chronic comorbidities (DCCs). Managing these patients within the current healthcare system often proves to be a challenging process, characterized by evolving treatment needs necessitating multiple medical appointments and coordination among different clinical specialists. This makes it difficult for both patients and healthcare providers to set and prioritize medications and understand potential drug interactions. The primary motivation of this research is the need to reduce medication conflict and optimize medication regimens for individuals with DCCs. To achieve this, we allowed patients to specify their health conditions and …


Gnss Software Defined Radio: History, Current Developments, And Standardization Efforts, Thomas Pany, Dennis Akos, Javier Arribas, M. Zahidul H. Bhuiyan, Pau Closas, Fabio Dovis, Ignacio Fernandez-Hernandez, Carles Fernandez-Prades, Sanjeev Gunawardena, Todd Humphreys, Zaher M. Kassas, Jose A. Lopez Salcedo, Mario Nicola, Mario L. Psiaki, Alexander Rugamer, Yong-Jin Song, Jong-Hoon Won Jan 2024

Gnss Software Defined Radio: History, Current Developments, And Standardization Efforts, Thomas Pany, Dennis Akos, Javier Arribas, M. Zahidul H. Bhuiyan, Pau Closas, Fabio Dovis, Ignacio Fernandez-Hernandez, Carles Fernandez-Prades, Sanjeev Gunawardena, Todd Humphreys, Zaher M. Kassas, Jose A. Lopez Salcedo, Mario Nicola, Mario L. Psiaki, Alexander Rugamer, Yong-Jin Song, Jong-Hoon Won

Faculty Publications

Taking the work conducted by the global navigation satellite system (GNSS) software-defined radio (SDR) working group during the last decade as a seed, this contribution summarizes, for the first time, the history of GNSS SDR development. This report highlights selected SDR implementations and achievements that are available to the public or that influenced the general development of SDR. Aspects related to the standardization process of intermediate-frequency sample data and metadata are discussed, and an update of the Institute of Navigation SDR Standard is proposed. This work focuses on GNSS SDR implementations in general-purpose processors and leaves aside developments conducted on …


Adaptable Object And Animation System For Game Development, Isaiah Turner Dec 2023

Adaptable Object And Animation System For Game Development, Isaiah Turner

Masters Theses & Specialist Projects

In contemporary times, video games have swiftly evolved into a prominent medium, excelling in both entertainment and narrative delivery, positioning themselves as significant rivals to traditional forms such as film and theater. The burgeoning popularity of gaming has led to a surge in aspiring game developers seeking to craft their own creations, driven by both commercial aspirations and personal passion. However, a common challenge faced by these individuals involves the considerable time investment required to acquire essential skills and establish a foundational framework for their projects. Accessible game development engines that offer a diverse range of fundamental features play a …


Closing The Gap: Leveraging Aes-Ni To Balance Adversarial Advantage And Honest User Performance In Argon2i, Nicholas Harrell, Nathaniel Krakauer Nov 2023

Closing The Gap: Leveraging Aes-Ni To Balance Adversarial Advantage And Honest User Performance In Argon2i, Nicholas Harrell, Nathaniel Krakauer

CERIAS Technical Reports

The challenge of providing data privacy and integrity while maintaining efficient performance for honest users is a persistent concern in cryptography. Attackers exploit advances in parallel hardware and custom circuit hardware to gain an advantage over regular users. One such method is the use of Application-Specific Integrated Circuits (ASICs) to optimize key derivation function (KDF) algorithms, giving adversaries a significant advantage in password guessing and recovery attacks. Other examples include using graphical processing units (GPUs) and field programmable gate arrays (FPGAs). We propose a focused approach to close the gap between adversarial advantage and honest user performance by leveraging the …


Hiking Trail Generation In Infinite Landscapes, Matthew Jensen Nov 2023

Hiking Trail Generation In Infinite Landscapes, Matthew Jensen

MS in Computer Science Project Reports

This project procedurally generates an infinite wilderness populated with deterministic hiking trails. Our approach recognizes that hiking trails depend on contextual information beyond the location of the path itself. To address this, we implemented a layered procedural system that orchestrates the generation process. This helps ensure the availability of contextual data at each stage. The first layer handles terrain generation, establishing the foundational landscape upon which trails will traverse. Subsequent layers handle point of interest identification and selection, trail network optimization through proximity graphs, and efficient pathfinding across the terrain. A notable feature of our approach is the deterministic nature …


Ai Vs. Ai: Can Ai Detect Ai-Generated Images?, Samah S. Baraheem, Tam Van Nguyen Sep 2023

Ai Vs. Ai: Can Ai Detect Ai-Generated Images?, Samah S. Baraheem, Tam Van Nguyen

Computer Science Faculty Publications

The proliferation of Artificial Intelligence (AI) models such as Generative Adversarial Net- works (GANs) has shown impressive success in image synthesis. Artificial GAN-based synthesized images have been widely spread over the Internet with the advancement in generating naturalistic and photo-realistic images. This might have the ability to improve content and media; however, it also constitutes a threat with regard to legitimacy, authenticity, and security. Moreover, implementing an automated system that is able to detect and recognize GAN-generated images is significant for image synthesis models as an evaluation tool, regardless of the input modality. To this end, we propose a framework …


Integrating Traditional Cs Class Activities With Computing For Social Good, Ethics, And Communications And Leadership Skills, Renato Cortinovis, Devender Goyal, Luiz Fernando Capretz Aug 2023

Integrating Traditional Cs Class Activities With Computing For Social Good, Ethics, And Communications And Leadership Skills, Renato Cortinovis, Devender Goyal, Luiz Fernando Capretz

Electrical and Computer Engineering Publications

Software and information technologies are becoming increasingly integrated and pervasive in human society and range from automated decision making and social media and entertainment, to running critical social and physical infrastructures like government programs, utilities, and financial institutions. As a result, there is a growing awareness of the need to develop professionals who will harness these technologies in fair and inclusive ways and use them to address global issues like health, water management, poverty, and human rights. In this regard, many academic researchers have expressed the need to complement traditional teaching of CS technical skills with computer and information ethics …


Verifying Empirical Predictive Modeling Of Societal Vulnerability To Hazardous Events: A Monte Carlo Experimental Approach, Yi Victor Wang, Seung Hee Kim, Menas C. Kafatos Aug 2023

Verifying Empirical Predictive Modeling Of Societal Vulnerability To Hazardous Events: A Monte Carlo Experimental Approach, Yi Victor Wang, Seung Hee Kim, Menas C. Kafatos

Institute for ECHO Articles and Research

With the emergence of large amounts of historical records on adverse impacts of hazardous events, empirical predictive modeling has been revived as a foundational paradigm for quantifying disaster vulnerability of societal systems. This paradigm models societal vulnerability to hazardous events as a vulnerability curve indicating an expected loss rate of a societal system with respect to a possible spectrum of intensity measure (IM) of an event. Although the empirical predictive models (EPMs) of societal vulnerability are calibrated on historical data, they should not be experimentally tested with data derived from field experiments on any societal system. Alternatively, in this paper, …


Multi-Scale Attention Networks For Pavement Defect Detection, Junde Chen, Yuxin Wen, Yaser Ahangari Nanehkaran, Defu Zhang, Adan Zeb Jul 2023

Multi-Scale Attention Networks For Pavement Defect Detection, Junde Chen, Yuxin Wen, Yaser Ahangari Nanehkaran, Defu Zhang, Adan Zeb

Engineering Faculty Articles and Research

Pavement defects such as cracks, net cracks, and pit slots can cause potential traffic safety problems. The timely detection and identification play a key role in reducing the harm of various pavement defects. Particularly, the recent development in deep learning-based CNNs has shown competitive performance in image detection and classification. To detect pavement defects automatically and improve effects, a multi-scale mobile attention-based network, which we termed MANet, is proposed to perform the detection of pavement defects. The architecture of the encoder-decoder is used in MANet, where the encoder adopts the MobileNet as the backbone network to extract pavement defect features. …


Understanding Data Mining And Its Relation To Information Systems, Malak Alammari May 2023

Understanding Data Mining And Its Relation To Information Systems, Malak Alammari

Publications and Research

This research project aims to enrich an Open Educational Resource (OER) textbook on Introduction to Information Systems/Technology with a focus on data mining and its relation to hardware and software components of information systems. The study will address the following research questions: (1) What is data mining? and (2) How does data relate to the hardware and software components of information systems? To answer these questions, the researcher will conduct research to ascertain the current state of data mining and its relevance in the field of information systems/technology. The results of the research will be incorporated into an existing OER …


From Deep Mutational Mapping Of Allosteric Protein Landscapes To Deep Learning Of Allostery And Hidden Allosteric Sites: Zooming In On “Allosteric Intersection” Of Biochemical And Big Data Approaches, Gennady M. Verkhivker, Mohammed Alshahrani, Grace Gupta, Sian Xiao, Peng Tao Apr 2023

From Deep Mutational Mapping Of Allosteric Protein Landscapes To Deep Learning Of Allostery And Hidden Allosteric Sites: Zooming In On “Allosteric Intersection” Of Biochemical And Big Data Approaches, Gennady M. Verkhivker, Mohammed Alshahrani, Grace Gupta, Sian Xiao, Peng Tao

Mathematics, Physics, and Computer Science Faculty Articles and Research

The recent advances in artificial intelligence (AI) and machine learning have driven the design of new expert systems and automated workflows that are able to model complex chemical and biological phenomena. In recent years, machine learning approaches have been developed and actively deployed to facilitate computational and experimental studies of protein dynamics and allosteric mechanisms. In this review, we discuss in detail new developments along two major directions of allosteric research through the lens of data-intensive biochemical approaches and AI-based computational methods. Despite considerable progress in applications of AI methods for protein structure and dynamics studies, the intersection between allosteric …


Counterventions: A Reparative Reflection On Interventionist Hci, Rua Mae Williams, Louanne E. Boyd, Juan E. Gilbert Apr 2023

Counterventions: A Reparative Reflection On Interventionist Hci, Rua Mae Williams, Louanne E. Boyd, Juan E. Gilbert

Engineering Faculty Articles and Research

Research in HCI applied to clinical interventions relies on normative assumptions about which bodies and minds are healthy, valuable, and desirable. To disrupt this normalizing drive in HCI, we define a “counterventional approach” to intervention technology design informed by critical scholarship and community perspectives. This approach is meant to unsettle normative assumptions of intervention as urgent, necessary, and curative. We begin with a historical overview of intervention in HCI and its critics. Then, through reparative readings of past HCI projects in autism intervention, we illustrate the emergent principles of a counterventional approach and how it may manifest research outcomes that …


Interpretable Learning In Multivariate Big Data Analysis For Network Monitoring, José Camacho, Rasmus Bro, David Kotz Apr 2023

Interpretable Learning In Multivariate Big Data Analysis For Network Monitoring, José Camacho, Rasmus Bro, David Kotz

Dartmouth Scholarship

There is an increasing interest in the development of new data-driven models useful to assess the performance of communication networks. For many applications, like network monitoring and troubleshooting, a data model is of little use if it cannot be interpreted by a human operator. In this paper, we present an extension of the Multivariate Big Data Analysis (MBDA) methodology, a recently proposed interpretable data analysis tool. In this extension, we propose a solution to the automatic derivation of features, a cornerstone step for the application of MBDA when the amount of data is massive. The resulting network monitoring approach allows …


Incel Bonding: Masculinity And Storytelling In Online Misogynist Spaces, Gunnar Eastman Apr 2023

Incel Bonding: Masculinity And Storytelling In Online Misogynist Spaces, Gunnar Eastman

Honors College

The incel subculture, short for “involuntary celibate,” is one that exists mostly online, but boasts a relatively large number of dedicated members. The goal of this research is to determine how the incel subculture shares their ideology and develops a sense of group identity. The study reviewed 76 threads of posts across two incel forum websites, and was able to conduct three interviews of members from one of those sites. That content was analyzed iteratively for cohesive themes. Several themes emerged, chief among them was the activity of storytelling, which appeared to be done in three different major ways, with …


Chatgpt As Metamorphosis Designer For The Future Of Artificial Intelligence (Ai): A Conceptual Investigation, Amarjit Kumar Singh (Library Assistant), Dr. Pankaj Mathur (Deputy Librarian) Mar 2023

Chatgpt As Metamorphosis Designer For The Future Of Artificial Intelligence (Ai): A Conceptual Investigation, Amarjit Kumar Singh (Library Assistant), Dr. Pankaj Mathur (Deputy Librarian)

Library Philosophy and Practice (e-journal)

Abstract

Purpose: The purpose of this research paper is to explore ChatGPT’s potential as an innovative designer tool for the future development of artificial intelligence. Specifically, this conceptual investigation aims to analyze ChatGPT’s capabilities as a tool for designing and developing near about human intelligent systems for futuristic used and developed in the field of Artificial Intelligence (AI). Also with the helps of this paper, researchers are analyzed the strengths and weaknesses of ChatGPT as a tool, and identify possible areas for improvement in its development and implementation. This investigation focused on the various features and functions of ChatGPT that …


Créativité Assistée Par Ordinateur : Composer La Musique D'Un Film En Utilisant Uniquement Sa Courbe De Luminosité Extraite Automatiquement, Felipe Ariani, Marcelo Caetano, Javier Elipe Gimeno, Ivan Magrin-Chagnolleau Jan 2023

Créativité Assistée Par Ordinateur : Composer La Musique D'Un Film En Utilisant Uniquement Sa Courbe De Luminosité Extraite Automatiquement, Felipe Ariani, Marcelo Caetano, Javier Elipe Gimeno, Ivan Magrin-Chagnolleau

Presidential Fellows Articles and Research

Dès sa conception, l'ordinateur a trouvé des applications pour accompagner la créativité des humains. De nos jours, le débat sur les ordinateurs et la créativité implique plusieurs défis, tels que comprendre la créativité humaine, modéliser le processus créatif, et programmer l'ordinateur pour qu'il présente un comportement qui semble être créatif dans une certaine mesure. Dans cet article, nous nous intéressons à la manière dont l'ordinateur peut être utilisé comme un outil favorisant la créativité dans une composition musicale. Nous avons extrait automatiquement la courbe de luminosité d'un film muet et l'avons ensuite utilisée pour composer une pièce musicale pour accompagner …


Completeness Of Nominal Props, Samuel Balco, Alexander Kurz Jan 2023

Completeness Of Nominal Props, Samuel Balco, Alexander Kurz

Engineering Faculty Articles and Research

We introduce nominal string diagrams as string diagrams internal in the category of nominal sets. This leads us to define nominal PROPs and nominal monoidal theories. We show that the categories of ordinary PROPs and nominal PROPs are equivalent. This equivalence is then extended to symmetric monoidal theories and nominal monoidal theories, which allows us to transfer completeness results between ordinary and nominal calculi for string diagrams.


Murder On The Vr Express: Studying The Impact Of Thought Experiments At A Distance In Virtual Reality, Andrew Kissel, Krzysztof J. Rechowicz, John B. Shull Jan 2023

Murder On The Vr Express: Studying The Impact Of Thought Experiments At A Distance In Virtual Reality, Andrew Kissel, Krzysztof J. Rechowicz, John B. Shull

Philosophy Faculty Publications

Hypothetical thought experiments allow researchers to gain insights into widespread moral intuitions and provide opportunities for individuals to explore their moral commitments. Previous thought experiment studies in virtual reality (VR) required participants to come to an on-site laboratory, which possibly restricted the study population, introduced an observer effect, and made internal reflection on the participants’ part more difficult. These shortcomings are particularly crucial today, as results from such studies are increasingly impacting the development of artificial intelligence systems, self-driving cars, and other technologies. This paper explores the viability of deploying thought experiments in commercially available in-home VR headsets. We conducted …


Evaluation Of Edison's Data Science Competency Framework Through A Comparative Literature Analysis, Karl R. B. Schmitt, Linda Clark, Katherine M. Kinnaird, Ruth E. H. Wertz, Björn Sandstede Jan 2023

Evaluation Of Edison's Data Science Competency Framework Through A Comparative Literature Analysis, Karl R. B. Schmitt, Linda Clark, Katherine M. Kinnaird, Ruth E. H. Wertz, Björn Sandstede

Statistical and Data Sciences: Faculty Publications

During the emergence of Data Science as a distinct discipline, discussions of what exactly constitutes Data Science have been a source of contention, with no clear resolution. These disagreements have been exacerbated by the lack of a clear single disciplinary 'parent.' Many early efforts at defining curricula and courses exist, with the EDISON Project's Data Science Framework (EDISON-DSF) from the European Union being the most complete. The EDISON-DSF includes both a Data Science Body of Knowledge (DS-BoK) and Competency Framework (CF-DS). This paper takes a critical look at how EDISON's CF-DS compares to recent work and other published curricular or …


Model Checking Time Window Temporal Logic For Hyperproperties, Ernest Bonnah, Luan Viet Nguyen, Khaza Anuarul Hoque Jan 2023

Model Checking Time Window Temporal Logic For Hyperproperties, Ernest Bonnah, Luan Viet Nguyen, Khaza Anuarul Hoque

Computer Science Faculty Publications

Hyperproperties extend trace properties to express properties of sets of traces, and they are increasingly popular in specifying various security and performance-related properties in domains such as cyber-physical systems, smart grids, and automotive. This paper introduces HyperTWTL, which extends Time Window Temporal Logic (TWTL)-a domain-specific formal specification language for robotics, by allowing explicit and simultaneous quantification over multiple execution traces. We propose two different semantics for HyperTWTL, synchronous and asynchronous, based on the alignment of the timestamps in the traces. Consequently, we demonstrate the application of HyperTWTL in formalizing important information-flow security policies and concurrency for robotics applications. Furthermore, we …


Uit-Adrone: A Novel Drone Dataset For Traffic Anomaly Detection, Tung Minh Tran, Tu N. Vu, Tam Nguyen, Khang Nguyen Jan 2023

Uit-Adrone: A Novel Drone Dataset For Traffic Anomaly Detection, Tung Minh Tran, Tu N. Vu, Tam Nguyen, Khang Nguyen

Computer Science Faculty Publications

Anomaly detection plays an increasingly important role in video surveillance and is one of the issues that have attracted various communities, such as computer vision, machine learning, and data mining in recent years. Moreover, drones equipped with cameras have quickly been deployed to a wide range of applications, starting from border security applications to street monitoring systems. However, there is a notable lack of adequate drone-based datasets available to detect unusual events in the urban traffic environment, especially in roundabouts, due to the density of interaction between road users and vehicles. To promote the development of anomalous event detection with …


Collaborative Consultation Doctors Model: Unifying Cnn And Vit For Covid-19 Diagnostic, Trong-Thuan Nguyen, Tam Nguyen, Minh-Triet Tran Jan 2023

Collaborative Consultation Doctors Model: Unifying Cnn And Vit For Covid-19 Diagnostic, Trong-Thuan Nguyen, Tam Nguyen, Minh-Triet Tran

Computer Science Faculty Publications

The COVID-19 pandemic presents significant challenges due to its high transmissibility and mortality risk. Traditional diagnostic methods, such as RT-PCR, have limitations that hinder timely and accurate screening. In response, AI-powered computer-aided imaging analysis techniques have emerged as a promising alternative for COVID-19 diagnosis. In this paper, we propose a novel approach that combines the strengths of Convolutional Neural Network (CNN) and Vision Transformer (ViT) to enhance the performance of COVID-19 diagnosis models. CNN excels at capturing spatial features in medical images, while ViT leverages self-attention mechanisms inspired by human radiologists. Additionally, our approach draws inspiration from subclinical diagnosis, a …


Explainable Ai Helps Bridge The Ai Skills Gap: Evidence From A Large Bank, Selina Carter, Jonathan Hersh Dec 2022

Explainable Ai Helps Bridge The Ai Skills Gap: Evidence From A Large Bank, Selina Carter, Jonathan Hersh

Economics Faculty Articles and Research

Advances in machine learning have created an “AI skills gap” both across and within firms. As AI becomes embedded in firm processes, it is unknown how this will impact the digital divide between workers with and without AI skills. In this paper we ask whether managers trust AI to predict consequential events, what manager characteristics are associated with increasing trust in AI predictions, and whether explainable AI (XAI) affects users’ trust in AI predictions. Partnering with a large bank, we generated AI predictions for whether a loan will be late in its final disbursement. We embedded these predictions into a …


College Teaching And Ai, Leo Irakliotis Dec 2022

College Teaching And Ai, Leo Irakliotis

Computer Science: Faculty Publications and Other Works

Artificial Intelligence will reshape the way we assess student learning in ways that no one has prepared us for.


Probing Conformational Landscapes And Mechanisms Of Allosteric Communication In The Functional States Of The Abl Kinase Domain Using Multiscale Simulations And Network-Based Mutational Profiling Of Allosteric Residue Potentials, Keerthi Krishnan, Hao Tian, Peng Tao, Gennady M. Verkhivker Dec 2022

Probing Conformational Landscapes And Mechanisms Of Allosteric Communication In The Functional States Of The Abl Kinase Domain Using Multiscale Simulations And Network-Based Mutational Profiling Of Allosteric Residue Potentials, Keerthi Krishnan, Hao Tian, Peng Tao, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In the current study, multiscale simulation approaches and dynamic network methods are employed to examine the dynamic and energetic details of conformational landscapes and allosteric interactions in the ABL kinase domain that determine the kinase functions. Using a plethora of synergistic computational approaches, we elucidate how conformational transitions between the active and inactive ABL states can employ allosteric regulatory switches to modulate intramolecular communication networks between the ATP site, the substrate binding region, and the allosteric binding pocket. A perturbation-based network approach that implements mutational profiling of allosteric residue propensities and communications in the ABL states is proposed. Consistent with …


The History Of The Enigma Machine, Jenna Siobhan Parkinson Dec 2022

The History Of The Enigma Machine, Jenna Siobhan Parkinson

History Publications

The history of the Enigma machine begins with the invention of the rotor-based cipher machine in 1915. Various models for rotor-based cipher machines were developed somewhat simultaneously in different parts of the world. However, the first documented rotor machine was developed by Dutch naval officers in 1915. Nonetheless, the Enigma machine was officially invented following the end of World War I by Arthur Scherbius in 1918 (Faint, 2016).