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Full-Text Articles in Physical Sciences and Mathematics
Water-Soluble Phthalocyanine Photosensitizers For Photodynamic Therapy, İpek Ömeroğlu, Mahmut Durmuş
Water-Soluble Phthalocyanine Photosensitizers For Photodynamic Therapy, İpek Ömeroğlu, Mahmut Durmuş
Turkish Journal of Chemistry
Photodynamic therapy (PDT) is based on a photochemical reaction that is started when a photosensitizing process is activated by the light and results in the death of tumor cells. Solubility is crucial in PDT applications to investigate the physical and chemical characteristics of phthalocyanines, but, unfortunately, most phthalocyanines show limited solubility especially in water. To increase the solubility of phthalocyanines in polar solvents and water, ionic groups such as -SO3 - , -NR3 +, -COO- , and nonionic groups such as poly-oxy chains are frequently added to the peripheral or nonperipheral positions of the phthalocyanine framework. Since water-solubility and NIR-absorbing …
Phthalocyanines Prepared From 4,5-Dihexylthiophthalonitrile, A Popular Building Block, Derya Topkaya Taşkiran, Zeynel Şahi̇n, Ümi̇t İşci̇, Fabi̇enne Dumouli̇n İşci̇
Phthalocyanines Prepared From 4,5-Dihexylthiophthalonitrile, A Popular Building Block, Derya Topkaya Taşkiran, Zeynel Şahi̇n, Ümi̇t İşci̇, Fabi̇enne Dumouli̇n İşci̇
Turkish Journal of Chemistry
Phthalocyanines are tetrapyrrolic artificial porphyrinoids that play major roles in advanced biological and technological applications. Research on this family of dyes is particularly active in Türkiye, with many derivatives being prepared from 4,5-dihexyl-thiophthalonitrile DiSHexPN, which is one of the most popular noncommercially available building blocks for phthalocyanines. This review summarizes the phthalocyanines and their versatile properties and applications that have been published since 1994, when the synthesis of DiSHexPN was first described, to emphasize the importance of this building block in plentiful applications, all with bio-medical or technological impact.
The Chemical And Electrochemical Stimuli Viologen Substituted Phthalocyanine With Tunable Optical Features1, Özge Di̇lara Ateş, Gülenay Tunç, Ahmet Şenocak, Burcu Dedeoğlu, Mehmet Menaf Ayhan, Ayşe Gül Gürek
The Chemical And Electrochemical Stimuli Viologen Substituted Phthalocyanine With Tunable Optical Features1, Özge Di̇lara Ateş, Gülenay Tunç, Ahmet Şenocak, Burcu Dedeoğlu, Mehmet Menaf Ayhan, Ayşe Gül Gürek
Turkish Journal of Chemistry
In this study, viologen-tetrasubstituted Zn(II) phthalocyanines (PcV1 and PcV2) were designed and synthesized to achieve the tunable optical features via redox-active viologen groups. Several parameters relevant to the evaluation of the tunable optical features have been investigated: UV-Vis, cyclic voltammetry (CV), EPR, square wave voltammetry (SWV), and theoretical analyses. The results showed that upon reductions and oxidations of viologen groups either chemically or electrochemically, the optical features of PcV1 and PcV2 change drastically with switchable processes. These outcomes indicate that achieving control over optical features of large organic chromophores such as Pc with our rational design can be used for …
Comparatively Sonophotochemical And Photochemical Studies Of Phthalocyanines With Cationic Substituents On Nonperipheral Positions, Mukaddes Özçeşmeci̇, Ceren Can Karanlik, Ali̇ Erdoğmuş, Esi̇n Hamuryudan
Comparatively Sonophotochemical And Photochemical Studies Of Phthalocyanines With Cationic Substituents On Nonperipheral Positions, Mukaddes Özçeşmeci̇, Ceren Can Karanlik, Ali̇ Erdoğmuş, Esi̇n Hamuryudan
Turkish Journal of Chemistry
The term sonophotodynamic therapy (SPDT) refers to a combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT), in which the efficacy of the treatment is boosted by utilizing the proper amount of a sensitizer that is responsive to both light and ultrasound. Although it has been proven in photophysicochemical studies that SPDT enhances singlet oxygen production, related studies in the literature are very limited. Considering this situation, this study aims to investigate the efficacy of synthesized phthalocyanines in terms of PDT and SPDT. The singlet oxygen quantum values calculated as 0.13 for 5, 0.44 for 6, and 0.61 for 7 …