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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of Silane- And Quaternary Ammonium-Bearing Copolymers And Application As A Coating Resin On Cotton Fabric, Ayşe Marti̇n, Nazgül Güler, İlknur Yerli̇, Hande Hançer, Tüli̇n Özbek, Tarik Eren
Synthesis Of Silane- And Quaternary Ammonium-Bearing Copolymers And Application As A Coating Resin On Cotton Fabric, Ayşe Marti̇n, Nazgül Güler, İlknur Yerli̇, Hande Hançer, Tüli̇n Özbek, Tarik Eren
Turkish Journal of Chemistry
In this study, silane and quaternary ammonium functional methacrylate monomers were synthesized and used to construct a copolymer using an emulsion polymerization technique to control the reaction rate. The copolymer was then designed using different ratios of silane and quaternary ammonium groups to investigate the relationship between the structure and properties. The presence of the ethoxy silane group in the copolymer series provided covalent bonding through the silanol group onto cotton fabric. The presence of cationic groups also helped to cover the fabric surface. After coating the cotton textile fabric, the resistance of the dye on the fabric surface to …
Investigation Of Antibacterial And Photocatalytic Efficiency Of Green Zno Nanoparticles That Synthesized With Celosia Cristata Flower Extract, Mahmure Özgür, Özgür Duygulu, Melda Altikatoğlu Yapaöz
Investigation Of Antibacterial And Photocatalytic Efficiency Of Green Zno Nanoparticles That Synthesized With Celosia Cristata Flower Extract, Mahmure Özgür, Özgür Duygulu, Melda Altikatoğlu Yapaöz
Turkish Journal of Chemistry
Increasing interest in green chemistry has led scientists to an environmentally friendly nanoparticle synthesis approach that has many advantages, such as simple, affordable and versatility for a wide range of commercial production. In this study, green synthesis of zinc oxide nanoparticles (ZnO NPs), which is widely researched in the field of nanotechnology, was performed under different conditions (volume ratio of CC flower extract to Zn(CH3COO)2 solution, time, pH and temperature) using the aqueous extract of Amarant (Celosia cristata L., CC, cockscome) plant flowers. Produced ZnO NPs were characterized by UV-Vis absorption spectroscopy, Fourier transform infrared spectroscopy (FTIR), high-resolution transmission electron …
Investigation Of Antibacterial Properties Of Polyacrylonitrile Fibers Modified By New Functional Groups And Silver Nanoparticles, Zeynep Okay, Meryem Kalkan Erdoğan, Başar Karaca, Meral Karakişla, Mehmet Saçak
Investigation Of Antibacterial Properties Of Polyacrylonitrile Fibers Modified By New Functional Groups And Silver Nanoparticles, Zeynep Okay, Meryem Kalkan Erdoğan, Başar Karaca, Meral Karakişla, Mehmet Saçak
Turkish Journal of Chemistry
This work reports the surface modification of polyacrylonitrile (PAN) fibers by graft copolymerization to ensure the decoration of homogenous and dense Ag nanoparticles. Two facile and subsequent modification processes resulted in a PAN fiber composite with an intact fibrous structure, sufficiently conductive for antistatic application and antibacterial activity. In the first step, some chemically attractive monomers and monomer mixtures, such as acrylic acid (AA), AA-itaconic acid (AA-IA), AA-acrylamide (AA-AAm), were introduced to the fiber surface by grafting. The grafting process was evidenced by FTIR, 1H-NMR, and SEM techniques. The second step aimed to form a chelate structure by Ag + …
Synthesis Of 2-Aryl-5-(Arylsulfonyl)-1,3,4-Oxadiazoles As Potent Antibacterial Andantioxidant Agents, S N Murthy Boddapati, Subrahmanyam Talari, A Emmanuel Kola, Bhuvaneswari Chalapaka
Synthesis Of 2-Aryl-5-(Arylsulfonyl)-1,3,4-Oxadiazoles As Potent Antibacterial Andantioxidant Agents, S N Murthy Boddapati, Subrahmanyam Talari, A Emmanuel Kola, Bhuvaneswari Chalapaka
Turkish Journal of Chemistry
Ten novel 2-aryl-5-(arylsulfonyl)-1,3,4-oxadiazoles were produced and assessed for their in vitro antibacterial and antioxidant activities. Diverse spectroscopic methods li1H NMR, 13C NMR, IR, and LCMS were used for the characterization of the prepared samples and all the data was in good agreement with the anticipated structures. The prepared compounds 6a-j were screened for their in vitro antibacterial activity against bacterial strains Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli (grampositive), and Bacillus cerus, Staphylococcus aureus, Bacillus subtilis (gram-negative). The antimicrobial screening outcome revealed that the prepared 2-(3,4-dimethylphenyl)-5-tosyl-1,3,4-oxadiazole (6j), 2-(3-isopropylphenyl)-5-tosyl-1,3,4-oxadiazole (6c), and 2-(2-ethylphenyl)-5-tosyl-1,3,4-oxadiazole (6i) are most potent among all the examined compounds. Furthermore, …
Novel Vic-Dioximes: Synthesis, Structure Characterization, And Antimicrobial Activity Evaluation, Dumitru Ureche, Ion Bulhac, Alexandru Ciocarlan, Daniel Roshca, Lucian Lupascu, Paulina Bourosh
Novel Vic-Dioximes: Synthesis, Structure Characterization, And Antimicrobial Activity Evaluation, Dumitru Ureche, Ion Bulhac, Alexandru Ciocarlan, Daniel Roshca, Lucian Lupascu, Paulina Bourosh
Turkish Journal of Chemistry
The vic-dioximes are compounds with various industrial uses and scientific applications. Many coordination compounds have been synthesized based on vic-dioximes. This study presents the synthesis and full characterization of two vic-dioximes based on dichloroglyoxime, p-aminobenzoic acid, and p-aminotoluene. Their structures were proved by IR, 1H, 13C and 15N NMR spectral analysis, and single crystal X-ray diffraction. One of the reported vic-dioximes, bis(di-p-aminotoluene)glyoxime mono-p-aminotoluene trihydrate showed good to moderate antimicrobial activity against both nonpathogenic gram-positive and gram-negative bacteria (Bacillus subtilis and Pseudomonas fluorescens), phytopathogenic (Xanthomonas campestris, Erwinia amylovora, E. carotovora) and the fungi (Candida utilis and Saccharomyces cerevisiae) at MIC - …
Synthesis, Spectral Characterization, And Biological Studies Of 3,5-Disubstituted- 1,3,4-Oxadiazole-2(3h)-Thione Derivatives, Tuğçe Özyazici, Fi̇kretti̇n Şahi̇n, Meri̇ç Köksal Akkoç
Synthesis, Spectral Characterization, And Biological Studies Of 3,5-Disubstituted- 1,3,4-Oxadiazole-2(3h)-Thione Derivatives, Tuğçe Özyazici, Fi̇kretti̇n Şahi̇n, Meri̇ç Köksal Akkoç
Turkish Journal of Chemistry
The reaction of 3,4-dichlorophenyl-1,3,4-oxadiazole-2(3H)-thione with piperidine derivatives via Mannich reaction was used to generate eleven novel compounds in moderate to good yields. Synthesized molecules were characterized according to their structure with 1H NMR, 13C NMR and FT-IR spectral foundations, which were compatible with literature informations. Antimicrobial activity and cytotoxicity studies were done by disc diffusion and NCI-60 sulphordamine B assay methods. The antimicrobial test results revealed that synthesized compounds have better activity against gram-positive species than gram-negative ones. A total analysis of the antibacterial, antifungal, and antiyeast activity revealed that newly synthesized compounds were really active against Bacillus cereus, Bacillus …
Cyclodextrin-Active Natural Compounds In Food Applications: A Review Of Antibacterial, Bingren Tian, Yumei Liu
Cyclodextrin-Active Natural Compounds In Food Applications: A Review Of Antibacterial, Bingren Tian, Yumei Liu
Turkish Journal of Chemistry
Many natural compounds have excellent activity against different bacteria. However, their food use to inhibit the bacteria is often limited by poor water solubility, or instability to light, heat, oxygen, and other environmental factors. Cyclodextrin combines with these natural compounds could not only overcome these shortcomings, but also increase the antibacterial ability of active compounds. This review focuses on the following aspects of active natural compounds in cyclodextrin-based food: the preparation, food applications, and their possible antibacterial mechanisms of different systems. Both cyclodextrin and its derivatives are able to selectively combine with different guest molecules, such as terpenes, phenols and …
Determination Of Characterization, Antibacterial And Drug Release Properties Of Poss-Based Film Synthesized With Sol-Gel Technique, İdi̇l Karaca Açari, Süleyman Köytepe, Burhan Ateş, İsmet Yilmaz, Turgay Seçki̇n
Determination Of Characterization, Antibacterial And Drug Release Properties Of Poss-Based Film Synthesized With Sol-Gel Technique, İdi̇l Karaca Açari, Süleyman Köytepe, Burhan Ateş, İsmet Yilmaz, Turgay Seçki̇n
Turkish Journal of Chemistry
In the study, antibacterial film synthesis was aimed using sol-gel technique from POSS structure with various functional groups. For this purpose, antibacterial properties have been acquired by metronidazole to the films to be synthesized. The films obtained were coated on glass surface samples by dip coating method. Antibacterial activities of surface coated glass samples were observed in E.coli and S. aureus bacteria. Metronidazole release studies in the film samples were followed by UV spectrophotometer. It was observed that drug release reached 68.90% at the end of the 24th h. As a result, it is thought that the synthesized film will …
Bioreduction: The Biological Activity, Characterization, And Synthesis Of Silver Nanoparticles, Nesri̇n Korkmaz
Bioreduction: The Biological Activity, Characterization, And Synthesis Of Silver Nanoparticles, Nesri̇n Korkmaz
Turkish Journal of Chemistry
Today, nanoparticles are effectively used in different areas. Initially, physical and chemical methods were used in the synthesis of nanoparticles. Biosynthesis (green synthesis) has emerged as an alternative to overcome the toxic effects of chemically synthesized nanoparticles. In this study, green synthesis of silver nanoparticles (AgNPs) with the leaf extract of Anthurium andraeanum was performed. UV-Vis spectrophotometry, scanning transmission electron microscopy, and XRD were applied to characterize the biosynthesized nanoparticles. As a result of the characterization, the spectra showed that a spectrum at a wavelength of about 419 nm and a spherical size of 38 nm nanoparticles was formed. Antibacterial …
Computational And Biological Studies Of Novel Thiazolyl Coumarin Derivatives Synthesized Through Suzuki Coupling, Shaista Parveen, Saima Kalsoom, Rifhat Bibi, Ambreen Asghar, Abdul Hameed, Waqar Ahmed, Abbas Hassan
Computational And Biological Studies Of Novel Thiazolyl Coumarin Derivatives Synthesized Through Suzuki Coupling, Shaista Parveen, Saima Kalsoom, Rifhat Bibi, Ambreen Asghar, Abdul Hameed, Waqar Ahmed, Abbas Hassan
Turkish Journal of Chemistry
The current investigation presents the synthesis, computational molecular-docking and biological activity studies of arylated thiazole coumarins. Aryl substituted thiazolyl coumarin derivatives were synthesized via Suzuki cross-coupling reaction. A detailed reaction condition optimization revealed that the Pd-PEPPSI-IPent precatalyst in only 2 mol% loading resulted in the desired product with high yield. The aim of this study was to examine the antimicrobial behavior of thiazole coumarin derivatives through in vitro and in silico studies. All the compounds showed activity against both antibacterial strains, Staphylococcus aureus and Escherichia coli, except 5d. Similarly, the compounds 5a, 5b, and 5d were found to be active …
Acid-Activated Clay As Heterogeneous And Reusable Catalyst For The Synthesis Of Bioactive Cyclic Ketal Derivatives, Wided Hagui, Rym Essid, Sondes Amri, Nadia Fares, Mohamed Khabbouchi, Olfa Tabbene, Ferid Limam, Ezzedine Srasra, Neji Besbes
Acid-Activated Clay As Heterogeneous And Reusable Catalyst For The Synthesis Of Bioactive Cyclic Ketal Derivatives, Wided Hagui, Rym Essid, Sondes Amri, Nadia Fares, Mohamed Khabbouchi, Olfa Tabbene, Ferid Limam, Ezzedine Srasra, Neji Besbes
Turkish Journal of Chemistry
A new heterogeneous acid catalyst based on a natural resource, Tunisian clay (Clay-H0.5), has been prepared and characterized by FT-IR, FE-SEM, and powder X-ray diffraction (XRD), as well as chemical composition, cation exchange capacity, specific surface area, and pore volume. Acid treatment for 0.5 h enlarged the surface area from 78.24 to 186.10 m$^{2}$/g and pore volume (PV) from 0.186 to 0.281 cm$^{3}$/g. The catalytic activity of this material was investigated in ketalization reaction under mild solvent-free conditions. This achieved up to 92% isolated yield for only 10 wt.% of the catalyst. This environmentally friendly method has advantages such as …
The Role Of Diazacrown Ether In The Enhancement Of The Biological Activity Of Silver Nanoparticles, Sarvinaz Hajiyeva, Ulviyya Hasanova, Zarema Gakhramanova, Aygun Israyilova, Khudaverdi Ganbarov, Eldar Gasimov, Fuad Rzayev, Goncha Eyvazova, Alakbar Huseynzada, Gunel Aliyeva, Ilaha Hasanova, Abel Maharramov
The Role Of Diazacrown Ether In The Enhancement Of The Biological Activity Of Silver Nanoparticles, Sarvinaz Hajiyeva, Ulviyya Hasanova, Zarema Gakhramanova, Aygun Israyilova, Khudaverdi Ganbarov, Eldar Gasimov, Fuad Rzayev, Goncha Eyvazova, Alakbar Huseynzada, Gunel Aliyeva, Ilaha Hasanova, Abel Maharramov
Turkish Journal of Chemistry
The nanostructuring of hydroxyl-substituted diazacrown-ether (DC) by silver nanoparticles was obtained by green synthesis method in order to increase the antibacterial activity of silver nanoparticles. The synthesized DC, nanoparticles, and nanosupramolecular complex (Ag@DC) were studied by TEM, powder-XRD, and NMR, IR, and UV spectroscopy methods. The Ag@DC nanostructures were uniform and their sizes ranged from 8 to 18 nm. IR and UV spectra revealed the noncovalent formation of the nanosupramolecular complex. The antibacterial activities of the prepared active agents were investigated on gram-positive and gram-negative bacteria by twofold microdilution method. Ultrastructural study by TEM was performed on \textit{E. coli} BDU12 …
Synthesis And Bioactivity Of Sulfide Derivatives Containing 1,3,4-Oxadiazole And Pyridine, Gang Yu, Shunhong Chen, Feng He, Dexia Luo, Yu Zhang, Jian Wu
Synthesis And Bioactivity Of Sulfide Derivatives Containing 1,3,4-Oxadiazole And Pyridine, Gang Yu, Shunhong Chen, Feng He, Dexia Luo, Yu Zhang, Jian Wu
Turkish Journal of Chemistry
A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g-6j toward tobacco bacterial wilt were much better than those of commercial thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L$^{-1}$.
Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan
Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan
Turkish Journal of Chemistry
The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a-6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1-tosylpiperidin-4-yl)-4$H$-1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones. Enzyme inhibition was carried out against lipoxygenase enzyme and results were supported by in silico study. The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.
Physicochemical Characterization Of Different Cellulose Polymorphs/Graphene Oxide Composites And Their Antibacterial Activity, Sherif Mohamed Abdel Salam Keshk, Ibrahim Sayed Yahia
Physicochemical Characterization Of Different Cellulose Polymorphs/Graphene Oxide Composites And Their Antibacterial Activity, Sherif Mohamed Abdel Salam Keshk, Ibrahim Sayed Yahia
Turkish Journal of Chemistry
In order to investigate the interaction of graphene oxide (GO) with different cellulose polymorphs (I and II), we synthesized cellulose (I and II)/GO composites using the sonication method. Interestingly, no new peaks were observed in the FT-IR pattern of the cellulose (I and II)/GO composites, indicating that no chemical reactions took place between GO and cellulose. The X-ray diffraction patterns of cellulose I and II/GO composites were slightly different than those observed for cellulose I and II, indicating that some physical interactions occurred between the GO and cellulose. Unexpectedly the $d$-spacing values and the diffraction plane at the high-angle side …
Synthesis, ($E)$/($Z)$-Isomerization, And Dna Binding, Antibacterial, And Antifungal Activities Of Novel Oximes And $O$-Substituted Oxime Ethers, Hati̇ce Başpinar Küçük, Ayşe Sergüzel Yusufoğlu, Leyla Açik, Betül Aydin, Leyla Arslan
Synthesis, ($E)$/($Z)$-Isomerization, And Dna Binding, Antibacterial, And Antifungal Activities Of Novel Oximes And $O$-Substituted Oxime Ethers, Hati̇ce Başpinar Küçük, Ayşe Sergüzel Yusufoğlu, Leyla Açik, Betül Aydin, Leyla Arslan
Turkish Journal of Chemistry
A series of novel positional oximes (2a-2d), $O$-methyl oxime ethers (3a-3d), and $O$-benzyl oxime ethers (4a-4d) were synthesized in high yields starting from their corresponding methyl 3-, 4-, 6-, and 13-keto tetradecanoates. The synthesized compounds were characterized by $^{1}$H NMR, $^{13}$C NMR, FT-IR, mass, and elemental analyses for their structures and $(E)$/$(Z)$ isomerizations. Their DNA binding abilities were investigated in vitro by agarose gel electrophoresis. The antibacterial and antifungal activities were tested also in vitro against eleven bacterial strains and three fungal strains. The relationship between the structure and the mentioned biological activities was discussed. Compound 2a showed good antibacterial …
New Antimicrobial Biscembrane Hydrocarbon And Cembranoid Diterpenes From The Soft Coral Sarcophyton Trocheliophorum, Muhammad Zubair, Walied Alarif, Khalid Al-Footy, Mohamed Ph, Magda Ali, Salim Basaif, Sultan Al-Lihaibi, Seif-Eldin Ayyad
New Antimicrobial Biscembrane Hydrocarbon And Cembranoid Diterpenes From The Soft Coral Sarcophyton Trocheliophorum, Muhammad Zubair, Walied Alarif, Khalid Al-Footy, Mohamed Ph, Magda Ali, Salim Basaif, Sultan Al-Lihaibi, Seif-Eldin Ayyad
Turkish Journal of Chemistry
A new tetracyclic biscembrane hydrocarbon, trocheliane (1), along with two new cembranoid diterpenes, sarcotrocheldiol A (2) and B (3), and the known diterpene cembrene-C (4), were isolated from the Red Sea soft coral Sarcophyton trocheliophorum. The structures and relative stereochemistry of the compounds were elucidated by interpretation of MS, 1 D NMR, and 2 D NMR experiments. The sensitivity of some pathogenic bacteria used as test organisms to the new compounds 1-3 was determined. 1 showed appreciable antimicrobial activity with the diameter of inhibition zones ranging from 11 to 18 mm. 1 was active against the two multidrug resistant bacteria …
One-Pot And Solvent-Free Synthesis Of 3-(9-Hydroxy-3-Methoxy-7-Aryl-6,7,9,10-Tetrahydro-5$H$-Benzo[$H$]Thiazolo[2,3-$B$]Quinazolin-9-Yl)-2$H$-Chromen-2-Ones And Their Antibacterial Evaluation, Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Yakaiah Sargam, Rajitha Bavantula
One-Pot And Solvent-Free Synthesis Of 3-(9-Hydroxy-3-Methoxy-7-Aryl-6,7,9,10-Tetrahydro-5$H$-Benzo[$H$]Thiazolo[2,3-$B$]Quinazolin-9-Yl)-2$H$-Chromen-2-Ones And Their Antibacterial Evaluation, Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Yakaiah Sargam, Rajitha Bavantula
Turkish Journal of Chemistry
A series of 3-(9-hydroxy-3-methoxy-7-aryl-6,7,9,10-tetrahydro-5$H$-benzo[$h$]thiazolo[2,3-$b$]quinazolin-9-yl)-2$H$-chromen-2-ones (5a-j) were synthesized by one-pot multicomponent reaction of 6-methoxy-1-tetralone, aryl aldehydes, and thiourea followed by cyclization with 3-(2-bromoacetyl)-2$H$-chromen-2-one in the presence of a Bronsted solid acid catalyst, poly(4-vinylpyridinium)hydrogen sulfate [P(4-VPH)HSO$_{4}$] (0.015 g), under solvent-free conditions at 120 $^{\circ}$C. All the synthesized compounds were characterized by spectral studies and screened for their in vitro antibacterial activity against S. aureus and B. thuringiensis (gram positive), and E. coli and K. pneumoniae (gram negative) bacterial strains. On comparing with the standard drug gentamicin, compounds derived from 4-methoxy and 3,4,5-trimethoxy benzaldehyde, i.e. 5g and 5h, showed broad spectrum antibacterial activity …
Synthesis Of New Pyrazole And Antibacterial Pyrazolopyrimidine Derivatives, Ameur Rahmouni, Anis Romdhane, Abderrahim Ben Said, Kaouther Majouli, Hichem Ben Jannet
Synthesis Of New Pyrazole And Antibacterial Pyrazolopyrimidine Derivatives, Ameur Rahmouni, Anis Romdhane, Abderrahim Ben Said, Kaouther Majouli, Hichem Ben Jannet
Turkish Journal of Chemistry
3-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines 2a--c were synthesized by treating 5-aminopyrazole-4-carbonitriles 1a--c with formamide. The reactivity of compounds 1a--c towards some cyclic anhydrides was studied. The condensation of 5-aminopyrazole-4-carbonitrile 1b with triethylorthoformate gives imidate 7b, which reacts with a series of primary amines and leads to pyrazolo[3,4-d]pyrimidine-4-amines 9 and 10. The reaction of imidate 7b with ammonia and hydroxylamine afforded pyrazolopyrimidine 2b and pyrazolo[3,4-d]pyrimidin-5-(4H)-ol 11, respectively. The synthesized compounds were completely characterized by ^1H NMR, ^{13}C NMR, IR, and HRMS. The antibacterial activity of some new synthesized compounds was evaluated and appeared to be significant.
Syntheses, Characterization, And Antibacterial Study Of Titanium Complexes, Raj Kaushal, Nitesh Kumar, Pamita Awasthi, Kiran Nehra
Syntheses, Characterization, And Antibacterial Study Of Titanium Complexes, Raj Kaushal, Nitesh Kumar, Pamita Awasthi, Kiran Nehra
Turkish Journal of Chemistry
Titanium(II) complexes of composition TiCl_2(L)_2 [where L = 2,2'-bipyridine (bipy), 4,4'-dimethyl-2,2'-bipyridine (bpMe), 4,4'-dimethoxy-2,2'-bipyridine (bpoMe), 6,6'-dimethyl-2,2'-bipyridine (dpMe), adamantylamine (ada)] were prepared by reacting titanium tetrachloride and N-containing bulky ligands in predetermined molar ratios. The complexes synthesized were characterized by different spectroscopic techniques, viz. UV-visible, FTIR, ^1H NMR, and mass spectrometry. The stoichiometry of the complexes was established by their elemental analysis (chlorine and titanium estimation). The unit cell parameters calculated by using the powder XRD tool confirm the monoclinic unit system and P lattice type for all complexes. Antibacterial screening of the ligands as well as the complexes was carried out …
Synthesis And Antimicrobial Activities Of Some Bridged Bis-Benzimidazole Derivatives, Hasan Küçükbay, Ülkü Yilmaz, Ni̇hat Şi̇reci̇, Ayşe Ni̇lay Güvenç
Synthesis And Antimicrobial Activities Of Some Bridged Bis-Benzimidazole Derivatives, Hasan Küçükbay, Ülkü Yilmaz, Ni̇hat Şi̇reci̇, Ayşe Ni̇lay Güvenç
Turkish Journal of Chemistry
Some bis-benzimidazoles derivatives bearing allyl, crotyl, cinammyl, furfuryl, and thenyl groups were synthesized and their in vitro antimicrobial activity determined against gram-positive and gram-negative bacteria, and fungi by disk-diffusion method. The structures of all new compounds were identified by ^1H-NMR, ^{13}C-NMR, and FT-IR spectroscopic techniques and elemental analysis. All the compounds synthesized in this work were examined for their in vitro antimicrobial activities against gram-positive (Staphylococcus aureus and Bacillus megaterium) and gram-negative bacteria (Klebsiella pneumoniae and Escherichia coli), and the yeasts like fungi (Candida globrata and Candida tropicalis). Compared to the reference substances, Cefozine and nystatin, most of the compounds …
Synthesis Of Some Pyridazine Derivatives Carrying Urea, Thiourea, And Sulfonamide Moieties And Their Antimicrobial Activity, Deni̇z S. Doğruer, Şölen Urlu, Ti̇jen Önkol, Berri̇n Özçeli̇k, M. Fethi̇ Şahi̇n
Synthesis Of Some Pyridazine Derivatives Carrying Urea, Thiourea, And Sulfonamide Moieties And Their Antimicrobial Activity, Deni̇z S. Doğruer, Şölen Urlu, Ti̇jen Önkol, Berri̇n Özçeli̇k, M. Fethi̇ Şahi̇n
Turkish Journal of Chemistry
Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by ^1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 \mu g/mL) and E. coli (MIC ranging from 4 to 16 \mu g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 \mu g/mL.
Synthesis, Characterization, Antibacterial And Antifungal Evaluation Of Some New Platinum(Ii) Complexes Of 2-Phenylbenzimidazole Ligands, Semra Utku, Mustafa Topal, Ayli̇n Döğen, Mehmet Sami̇ Seri̇n
Synthesis, Characterization, Antibacterial And Antifungal Evaluation Of Some New Platinum(Ii) Complexes Of 2-Phenylbenzimidazole Ligands, Semra Utku, Mustafa Topal, Ayli̇n Döğen, Mehmet Sami̇ Seri̇n
Turkish Journal of Chemistry
A series of platinum(II) complexes of the type [PtL_2Cl_2] 1, [PtL_2I_2] 2, [PtL_2(oxalato)] 3, and [PtL_2(malonato)] 4 (L= 2-phenylbenzimidazole ligands as ``non-leaving groups'') were synthesized and characterized by their elemental analyses, IR, ^1H NMR, and ESI-LC/MS. The in vitro antimicrobial activity of the synthesized compounds has been evaluated by the macrodilution method against gram-positive bacteria, such as Staphylococcus aureus, Bacillus subtilis, and Enterococcus faecalis; gram-negative bacteria, such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia; and yeast like fungi, such as Candida glabrata and Candida parapsilosis. In general, based on the data obtained in this study, synthesized complexes 1-4 might …
Synthesis, Spectroscopic And Biological Investigation Of Cyclic Octapeptide: Cherimolacyclopeptide G, Rajiv Dahiya
Synthesis, Spectroscopic And Biological Investigation Of Cyclic Octapeptide: Cherimolacyclopeptide G, Rajiv Dahiya
Turkish Journal of Chemistry
A natural cyclic octapeptide cherimolacyclopeptide G (8) was synthesized by coupling of tetrapeptide units Boc-Gly-Ala-Val-Pro-OMe (5) and Boc-Ile-Tyr-Ala-Pro-OMe (6) after proper deprotection at carboxyl and amino terminals followed by cyclization of the linear peptide segment. The structure was elucidated by IR, ^1H-NMR, ^{13}C-NMR, FAB MS spectral data, and elemental analyses. The newly synthesized cyclopeptide was also evaluated for its antimicrobial, anthelmintic, and cytotoxic activities and found to exhibit potent anthelmintic and cytotoxic activity against earthworms, Megascoplex konkanensis, Pontoscotex corethruses, and Eudrilus species, and Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines. In addition, compound 8 possessed moderate …
Gc-Ms Analysis And Antibacterial Activity Of Cultivated Satureja Cuneifolia Ten. Essential Oil, Yüksel Kan, Uçkun Sai̇t Uçan, Murat Kartal, M. Levent Altun, Si̇nem Aslan, Esi̇n Sayar, Ti̇murhan Ceyhan
Gc-Ms Analysis And Antibacterial Activity Of Cultivated Satureja Cuneifolia Ten. Essential Oil, Yüksel Kan, Uçkun Sai̇t Uçan, Murat Kartal, M. Levent Altun, Si̇nem Aslan, Esi̇n Sayar, Ti̇murhan Ceyhan
Turkish Journal of Chemistry
The composition of the essential oil of Satureja cuneifolia Ten. cultivated in Konya, Turkey, was investigated by capillary GC-MS. The compounds were characterized by comparison with library searches. Six main compounds were identified. Carvacrol was the dominant component, comprising 59.28% of the essential oil. The oil also contained 15.72% thymol, 9.69% p-cymene, 4.16% \gamma -terpinene, 1.70% linalool and 1.25% borneol. The antibacterial activity of the essential oil of S. cuneifolia and its components was determined by a semiquantative disc-diffusion method, and the minimum inhibitory concentration (MIC) was determined based on a micro-well dilution method against strains of Pseudomonas aeruginosa, Bacillus …
Synthesis, Crystal Structure And Antifungal/Antibacterial Activity Of Some Novel Highly Functionalized Benzoylaminocarbothioyl Pyrrolidines, H. Ali̇ Döndaş, Yahya Nural, Ni̇zami̇ Duran, Colin Kilner
Synthesis, Crystal Structure And Antifungal/Antibacterial Activity Of Some Novel Highly Functionalized Benzoylaminocarbothioyl Pyrrolidines, H. Ali̇ Döndaş, Yahya Nural, Ni̇zami̇ Duran, Colin Kilner
Turkish Journal of Chemistry
A series of novel highly functionalized benzoylaminocarbothioyl pyrrolidines were prepared from benzoylisothiocyanate and substituted pyrrolidines in excellent yield. The crystal structure of the novel 1-benzoylaminocarbothioyl-5-(naphthyl)- pyrrolidine-2,3,4-tricarboxylicacid trimethyl ester (3a) was determined by X-ray crystal structure analysis. The synthesized compounds were characterized and screened for their in vitro antibacterial and antifungal activities and toxicity. The prepared compounds were tested against the standard strains: Escherichia coli (ATCC 25922), Enterobacter cloacae (ATCC 13047), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 29213) and Staphylococcus epidermidis (ATCC 12228) and the yeasts Candida albicans (ATCC 90028), Candida krusei (ATCC 6258), Candida parapsilosis …
A Concise Synthesis And The Antibacterial Activity Of 5,6-Dimethoxynaphthalene-2-Carboxylic Acid, Süleyman Göksu, Meti̇n Tansu Uğuz, Hasan Özdemi̇r, Hasan Seçen
A Concise Synthesis And The Antibacterial Activity Of 5,6-Dimethoxynaphthalene-2-Carboxylic Acid, Süleyman Göksu, Meti̇n Tansu Uğuz, Hasan Özdemi̇r, Hasan Seçen
Turkish Journal of Chemistry
5,6-Dimethoxynaphthalene-2-carboxylic acid was synthesized in 7 steps and with an overall yield of 46%. Bromination of 2-naphthol, and methylation with dimethyl sulfate followed by Friedel-Crafts acylation with AcCl gave 2-acetyl-5-bromo-6-methoxynaphthalene. 2-Acetyl-5-bromo-6-methoxynaphthalene was converted to 5-bromo-6- methoxynaphthalene-2-carboxylic acid by a haloform reaction. The esterification of the acid with methanol, methoxylation with NaOCH_3 in the presence of CuI and subsequent de-esterification with NaOH afforded 5,6-dimethoxynaphthalene-2-carboxylic acid. The 5-bromo-6-methoxynaphthalene-2-carboxylic acid and 5,6-dimethoxynaphthalene-2-carboxylic acid were found to have in vitro antibacterial activity against some pathogenic bacteria.
Synthesis Of New Antimicrobial Agents; Amide Derivatives Of Pyranones And Pyridinones, Mutlu Di̇lsi̇z Aytemi̇r, Robert C. Hider, Di̇lek Demi̇r Erol, Meral Özalp, Meli̇ke Eki̇zoğlu
Synthesis Of New Antimicrobial Agents; Amide Derivatives Of Pyranones And Pyridinones, Mutlu Di̇lsi̇z Aytemi̇r, Robert C. Hider, Di̇lek Demi̇r Erol, Meral Özalp, Meli̇ke Eki̇zoğlu
Turkish Journal of Chemistry
In this study, 4(1H)-pyridinones with an amide function in Position 2 of the pyridinone ring showed antimicrobial activity. The synthesis and the biological properties of some novel amide derivatives of pyran-4(1H)-one and 4(1H)-pyridinone have been reported. Amide derivatives of pyran-4(1H)-one and 4(1H)-pyridinone were prepared using two different methods. Antimicrobial activities were determined as MIC values using the microdilution broth method against the bacteria Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa and the fungi Candida albicans, Candida krusei and Candida parapsilosis. Compounds 6 and 9 exhibited the best inhibitor activity against S. aureus.
Synthesis And Evaluation Of Antimicrobial Activity Of New 3-Hydroxy-6-Methyl-4-Oxo-4h-Pyran-2- Carboxamide Derivatives, Mutlu Di̇lsi̇z Aytemi̇r, Di̇lek Demi̇r Erol, Robert Charles Hider, Meral Özalp
Synthesis And Evaluation Of Antimicrobial Activity Of New 3-Hydroxy-6-Methyl-4-Oxo-4h-Pyran-2- Carboxamide Derivatives, Mutlu Di̇lsi̇z Aytemi̇r, Di̇lek Demi̇r Erol, Robert Charles Hider, Meral Özalp
Turkish Journal of Chemistry
The synthesis of a range of 3-hydroxy-4-oxo-4H-pyran-2- carboxamide with antimicrobial activity is described. Amide derivatives of pyranone were synthesised using TBTU [2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate] as a coupling agent and NMM (N-methylmorpholine) as a base. Antimicrobial activities were determined as MIC values using the microdilution broth method against Staphylococcus aureus, Entrococcus faecalis, Escherichia coli and Pseudomonas aeruginosa for bacteria and Candida albicans, C. krusei and C. parapsilosis for fungi. 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-[N-(4'-methylcoumarin-7-yl) carboxamide] (8c) exhibited higher antibacterial activity against S. aureus, E. faecalis and E. coli than the other compounds. In addition, 8c was more active against C. krusei than the other synthesised compounds.