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Full-Text Articles in Physical Sciences and Mathematics
Biological Study On Novel Coumarinyl 1,3,4-Oxadiazoles, Maja Molnar, Ana Amic, Valentina Pavic, Tihomir Kovac, Marija Kovac, Elizabeta Has-Schön
Biological Study On Novel Coumarinyl 1,3,4-Oxadiazoles, Maja Molnar, Ana Amic, Valentina Pavic, Tihomir Kovac, Marija Kovac, Elizabeta Has-Schön
Turkish Journal of Chemistry
Coumarinyl 1,3,4-oxadiazoles were synthesized from Schiff bases and acetic anhydride. All compounds were characterized by melting points and their structures confirmed by mass and $^{1}$H and $^{13}$C NMR spectrometry. These novel coumarinyl derivatives were subjected to antibacterial, antifungal, anta atoxigenic, and antioxidant activity. Their activity varied depending on their structure, where 2-(3-acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)- 2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,4-phenylene diacetate showed significant antioxidant and antibacterial activity on B. subtilis. 4-(3-Acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,2-phenylene diacetate was found to possess excellent antifungal and antia atoxigenic activity.
The Synthesis Of New Oxindoles As Analogs Of Natural Product 3,3$^\Prime $-Bis(Indolyl)Oxindole And In Vitro Evaluation Of The Enzyme Activity Of G6pd And 6pgd, Si̇nan Bayindir, Adnan Ayna, Yusuf Temel, Mehmet Çi̇ftci̇
The Synthesis Of New Oxindoles As Analogs Of Natural Product 3,3$^\Prime $-Bis(Indolyl)Oxindole And In Vitro Evaluation Of The Enzyme Activity Of G6pd And 6pgd, Si̇nan Bayindir, Adnan Ayna, Yusuf Temel, Mehmet Çi̇ftci̇
Turkish Journal of Chemistry
Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes. Therefore, the development of new synthetic methods for the synthesis of indole derivatives is very popular. In this study, new oxindoles with reaction of 4,7-dihydro-1$H$-indole (2) and isatin (4) were synthesized as analogs of natural product 3,3$^\prime $-bis(indolyl)oxindole. The biological properties of the compounds obtained during this study were also studied, showing that compounds 5, 7, and 12 inhibited the activity of G6PD with an IC$_{50}$ of 99 $\mu $M, 231 $\mu $M, and 304 $\mu $M respectively. The activity of rat …
Synthesis And Characterizations Of Novel Thiazolyl-Thiadiazole Derivatives As Telomerase Activators, İsmai̇l Kayaği̇l, Ayşe Gül Mutlu, Ülkü Bayhan, İnanç Yilmaz, Şeref Demi̇rayak
Synthesis And Characterizations Of Novel Thiazolyl-Thiadiazole Derivatives As Telomerase Activators, İsmai̇l Kayaği̇l, Ayşe Gül Mutlu, Ülkü Bayhan, İnanç Yilmaz, Şeref Demi̇rayak
Turkish Journal of Chemistry
Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds. The pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl 2-chloroacetoacetate in ethanol to give the thiazole derivatives (1, 2). The two ethyl thiazole-carboxylate derivatives (1, 2) thus obtained were treated with sodium hydroxide solution and ethanol and converted to carboxylic acids (3, 4). The carboxylic acid derivatives (3, 4) were reacted with thiosemicarbazide in phosphoroxy trichloride and aminothiadiazole rings (5, 6) were formed. Thus, two thiazolyl-thiadiazole amine derivatives (5, 6) were obtained. These two derivatives (5, 6) were converted into two chloroacetamidothiadiazole derivatives (7, 8) by reaction with …
Synthesis And Evaluation Of Novel 1,3,4-Thiadiazole--Fluoroquinolone Hybrids As Antibacterial, Antituberculosis, And Anticancer Agents, Asli Demi̇rci̇, Kaan Gökçe Karayel, Esra Tatar, Si̇nem Öktem Okullu, Ni̇han Ünübol, Paki̇ze Nesli̇han Taşli, Zühtü Tanil Kocagöz, Fi̇kretti̇n Şahi̇n, İlkay Küçükgüzel
Synthesis And Evaluation Of Novel 1,3,4-Thiadiazole--Fluoroquinolone Hybrids As Antibacterial, Antituberculosis, And Anticancer Agents, Asli Demi̇rci̇, Kaan Gökçe Karayel, Esra Tatar, Si̇nem Öktem Okullu, Ni̇han Ünübol, Paki̇ze Nesli̇han Taşli, Zühtü Tanil Kocagöz, Fi̇kretti̇n Şahi̇n, İlkay Küçükgüzel
Turkish Journal of Chemistry
A series of 5-substituted-1,3,4-thiadiazole-based fluoroquinolone derivatives were designed as potential antibacterial and anticancer agents using a molecular hybridization approach. The target compounds 16-25 were synthesized by reacting the corresponding $N$-(5-substituted-1,3,4-thiadiazol-2-yl)-2-chloroacetamides with ciprofloxacin or norfloxacin. The purity and identity of the synthesized compounds were determined by the use of chromatographic and spectral techniques (NMR, IR, MS, etc.) besides elemental analysis. Antibacterial, antituberculosis, and anticancer activity of the target compounds were evaluated against selected strains and cancer cell lines. Compound 20 was appreciated as the most active agent representing antibacterial activity against Escherichia coli and Staphylococcus aureus with MIC values of 4 …
A Rapid And Sensitive Spectrofluorometric Method For The Determination Of Au(Iii) Based On Fluorescence Quenching Of A 1,3,5-Triphenyl-2-Pyrazoline, Aysel Başoğlu, Ümmühan Ocak, Seda Fandakli, Nuretti̇n Yayli
A Rapid And Sensitive Spectrofluorometric Method For The Determination Of Au(Iii) Based On Fluorescence Quenching Of A 1,3,5-Triphenyl-2-Pyrazoline, Aysel Başoğlu, Ümmühan Ocak, Seda Fandakli, Nuretti̇n Yayli
Turkish Journal of Chemistry
A simple, rapid, sensitive, and low-cost spectrofluorometric method was developed for the determination of Au(III) using 5-(2,3-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole (L) in ethanol/water. The method is based on the change in the fluorescence intensity at 464 nm after excitation at 355 nm as a result of the reaction between the ligand and Au(III). The fluorescent emission of ligand at 464 nm decreased with the increasing of Au(III) concentration. The ligand concentration, pH effect, response time, and effect of foreign ions were determined. From the results of fluorescence titration experiments, it was found that the ligand (1 $\times $ 10$^{-7}$ M) was selective and …