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Full-Text Articles in Physical Sciences and Mathematics
An Efficient Synthesis Of (1 S , 2 R )-1-Amino-2-Indanol, A Key Intermediate Of Hiv Protease Inhibitor, Indinavir, Ayhan S. Demi̇r, Hi̇lal Aksoy-Cam, Nuretti̇n Camketen, Haluk Hamamci, Fatoş Doğanel
An Efficient Synthesis Of (1 S , 2 R )-1-Amino-2-Indanol, A Key Intermediate Of Hiv Protease Inhibitor, Indinavir, Ayhan S. Demi̇r, Hi̇lal Aksoy-Cam, Nuretti̇n Camketen, Haluk Hamamci, Fatoş Doğanel
Turkish Journal of Chemistry
(1S,2R)-1-amino-2-indanol, a key component of an HIV protease inhibitor is synthesized in four steps starting from indanone. The Mn(OAC)_3 mediated acetoxylation of indanone followed by fungus catalyzed hydrolysis of acetoxyindanone furnished optically pure \alpha-hydroxy indanone. Formation and enantioselective reduction of oxime ether of 2-hydroxyindanone afforded (1S, 2R)-1-amino-2-indanol in 97% {\it cis} selectivity.