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Conference

2006

High throughput screening

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Decision Quality Metrics – A Tool For Managing Quality Of Repeated Bioassays, Nancy Ferry, William Letsinger Apr 2006

Decision Quality Metrics – A Tool For Managing Quality Of Repeated Bioassays, Nancy Ferry, William Letsinger

Conference on Applied Statistics in Agriculture

Bioassays are often used in tiered screening systems to detect potential products, such as crop protection products. Often these assays are not replicated. The ultimate products of these bioassays are decisions, with biologically “active” compounds advanced to the next level of screening. Activity is determined by the response of the test organisms (e.g., weeds, insects or fungi) to each compound. The reproducibility of the bioassay is crucial. There are two types of possible errors in screening, false positives and false negatives. The quality of the decisions based upon these bioassays can be monitored through time using controls. This paper will …