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Introduction To Bayesian Quantitative Trait Locus Analysis For Polyploids, Dachuang Cao, Bruce A. Craig, R. W. Doerge

Conference on Applied Statistics in Agriculture

Quantitative Trait Locus (QTL) mapping in polyploids is complicated by the un-observable parental QTL con guration, especially the number of copies (dosage) of the QTL. Existing techniques estimate the parental QTL con guration using a profile likelihood approach and do not address the uncertainty in the estimates. In this paper, a Bayesian method is proposed to jointly model the parameters including the parental QTL configuration, QTL location, and QTL effects. Inference for parameters is obtained by integrating the posterior distribution of the parameters via a Markov chain Monte Carlo (MCMC) sampler, which is a hybrid of the Metropolis-Hastings, Gibbs, and …