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Synthesis And Conformational Study Of Triazolylcyclohexanols And Trans-2-(Azaarylsulfanyl)-Cyclohexanols, Mulinde R. Ruyonga
Synthesis And Conformational Study Of Triazolylcyclohexanols And Trans-2-(Azaarylsulfanyl)-Cyclohexanols, Mulinde R. Ruyonga
University of the Pacific Theses and Dissertations
Amino-cyclohexanol derivatives have been successful models for pH-triggered conformational switches. By changing the groups on the amine nitrogen, these models provide a wide pH-range in which a switch can occur. The pH-induced switch of conformation can be monitored by 1H NMR.In this work, structurally similar trans-2-(azaarylsulfanyl)-cyclohexanol derivatives (Scheme 1) and trans-2-triazolylcyclohexanol derivatives (Scheme 2) have been explored for the first time as compounds with a potential for the analogous pH-induced conformational switch. The azaarylsulfanyl groups showed selective conformational flexibility while the triazolyl group showed a strong preference for the equatorial position. Further, conformational studies were done on a series of …
Bayesian-Derived Vancomycin Auc24h Threshold For Nephrotoxicity In Special Populations, Dan Ho
Bayesian-Derived Vancomycin Auc24h Threshold For Nephrotoxicity In Special Populations, Dan Ho
University of the Pacific Theses and Dissertations
A Bayesian-derived 24-hour area under the concentration-time curve over minimum inhibitory concentration from broth microdilution (AUC24h/MICBMD) ratio of 400 to 600 is recommended as the new monitoring parameter for vancomycin to optimize efficacy and minimize nephrotoxicity. The AUC24h threshold of 600 mg*h/L for nephrotoxicity was extrapolated from studies that assessed the general population. It is unclear if this upper threshold is consistent or varies when used in special populations such as critically ill patients, obese patients, patients with preexisting renal disease, and patients on concomitant nephrotoxins.The purpose of this study is to investigate the generalizability of the proposed vancomycin AUC24h …