Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Bright Light Therapy And Depression: Assessing Suitability Using Entrainment Maps, Charles A. Mainwaring
Bright Light Therapy And Depression: Assessing Suitability Using Entrainment Maps, Charles A. Mainwaring
Theses
Bright Light Therapy has been shown to be efficacious to mood disorders including Major Depression. Researchers use the Jewett-Forger-Kronauer model of the circadian rhythm with the Unified Model of melatonin including a mathematical term implementing feedback from the melatonin system into the circadian system to quantify the effects of bright light. Early investigations into intrinsic period, light sensitivity, and the circadian pacemaker's sensitivity to blood melatonin concentration may be indicators of subsets of patients with long intrinsic periods exhibiting symptoms of depression.
An Analysis Of The Periodicity Of The Cell Cycle And Apoptotic Regulatory Proteins In Prostate Xenografts Using Anova And Cosinor Methods, Aleen Hosdaghian
An Analysis Of The Periodicity Of The Cell Cycle And Apoptotic Regulatory Proteins In Prostate Xenografts Using Anova And Cosinor Methods, Aleen Hosdaghian
Theses
Circadian rhythms have been found in both plants and animals, in normal tissues as well as in most tumors and human cancers. By following these rhythms in healthy and cancerous tissue, it has been possible to find optimal times to deliver a dose of drug, such that efficacy is maximized and toxicity to normal tissues is minimized. In this study, the periodicity of several cell cycle and apoptotic regulatory proteins were studied in two prostate cancer models against a dietary therapeutic agent, Selenium. The ALVA-3 1 (androgen-independent) and PC-3 (androgen-independent) prostate cancer cell lines were grown in vivo, as a …