Physical Sciences and Mathematics Commons^™

Conversion Of Fat To Cellular Fuel—Fatty Acids 𝛽-Oxidation Model, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Marissa Miller, Beata J. Wysocki, Paul Davis, Tadeusz A. Wysocki

School of Computing: Faculty Publications

𝛽-oxidation of fatty acids plays a significant role in the energy metabolism of the cell. This paper presents a 𝛽-oxidation model of fatty acids based on queueing theory. It uses Michaelis–Menten enzyme kinetics, and literature data on metabolites’ concentration and enzymatic constants. A genetic algorithm was used to optimize the parameters for the pathway reactions. The model enables real-time tracking of changes in the concentrations of metabolites with different carbon chain lengths. Another application of the presented model is to predict the changes caused by system disturbance, such as altered enzyme activity or abnormal fatty acid concentration. The model has …