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Full-Text Articles in Physical Sciences and Mathematics
Synthesis And Evaluations Of “1,4-Triazolyl Combretacoumarins” And Desmethoxy Analogs, Tashrique A. Khandaker, Jessica D. Hess, Renato Aguilera, Graciela Andrei, Robert Snoeck, Dominique Schols, Padmanava Pradhan, Mahesh K. Lakshman
Synthesis And Evaluations Of “1,4-Triazolyl Combretacoumarins” And Desmethoxy Analogs, Tashrique A. Khandaker, Jessica D. Hess, Renato Aguilera, Graciela Andrei, Robert Snoeck, Dominique Schols, Padmanava Pradhan, Mahesh K. Lakshman
Publications and Research
1,4-Triazolyl combretacoumarins have been prepared by linking the trimethoxyarene unit of combretastatin A4 with coumarins, via a 1,2,3-triazole. For this, 4-azidocoumarins were accessed by a sequential two-step, one-pot reaction of 4-hydroxycoumarins with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), followed by reaction with NaN3. In the reaction with BOP, a coumarin-derived phosphonium ion intermediate seems to form, leading to an O4-(benzotriazolyl)coumarin derivative. For the CuAAC reaction of azidocoumarins with 5-ethynyl-1,2,3-trimethoxybenzene, catalytic [(MeCN)4Cu]PF6 in CH2Cl2/MeOH with 2,6-lutidine, at 50 oC, was suitable. The 4-azidocoumarins were less reactive as compared to PhN3 and …
Toxins In Newtown Creek, Burl Yearwood, Cho Cho Aung, Ridima Pradhan, Jennifer Vance
Toxins In Newtown Creek, Burl Yearwood, Cho Cho Aung, Ridima Pradhan, Jennifer Vance
Publications and Research
Newtown Creek is a 3.5 mile river which empties into the East River in New York, United States. The river runs the boundary between the Queens and Brooklyn Burroughs. A thriving sight of industry, this river has been the location of much pollution for over a century. Battered by oil spills and oil seepage, raw sewage, trash carried by rain water, cement, animal fat, and a 15 meter sludge on the bottom of the riverbed, Newtown Creek is one of the most polluted waterways in the United States. In this article, data for nitrate, phosphate, lead, copper, dissolved iron, and …