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Epr, Endor And Dft Studies On X-Irradiated Single Crystals Of L-Lysine Monohydrochloride Monohydrate And L-Arginine Monohydrocloride Monohydrate, Yiying Zhou
Physics and Astronomy Dissertations
When proteins and DNA interact, arginine and lysine are the two amino acids most often in close contact with the DNA. In order to understand the radiation damage to DNA in vivo, which is always associated with protein, it is important to learn the radiation chemistry of arginine and lysine independently, and when complexed to DNA. This work studied X-irradiated single crystals of L-lysine monohydrochloride dihydrate (L-lysine·HCl·2H2O) and L-arginine monohydrochloride monohydrate (L-arginine·HCl·H2O) with EPR, ENDOR, EIE techniques and DFT calculations. In both crystal types irradiated at 66K, the carboxyl anion radical and the decarboxylation radical were detected. DFT calculations supported …
X-Irradiation Of Dna Components In The Solid State: Experimental And Computational Studies Of Stabilized Radicals In Guanine Derivatives, Nayana Kumudini Jayatilaka
X-Irradiation Of Dna Components In The Solid State: Experimental And Computational Studies Of Stabilized Radicals In Guanine Derivatives, Nayana Kumudini Jayatilaka
Physics and Astronomy Dissertations
Single crystals of sodium salt of guanosine dihydrate and 9 Ethyl Guanine were X-irradiated with the objective of identifying the radical products. Study with K-band EPR, ENDOR, and ENDOR-Induced EPR techniques indicated at least four radical species to appear in both crystals in the temperature range of 6K to room temperature. Three of these radicals (Radicals R1, R2, and R3) were present immediately after irradiation at 6K. Computational chemistry and EPR spectrum simulation methods were also used to assist in radical identifications. Radical R1, the product of net hydrogen addition to N7, and Radical R2, the product of electron loss …