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Full-Text Articles in Physical Sciences and Mathematics
Splitting Nodes And Linking Channels: A Method For Assembling Biocircuits From Stochastic Elementary Units, Cameron Ferwerda, Ovidiu Lipan
Splitting Nodes And Linking Channels: A Method For Assembling Biocircuits From Stochastic Elementary Units, Cameron Ferwerda, Ovidiu Lipan
Physics Faculty Publications
Akin to electric circuits, we construct biocircuits that are manipulated by cutting and assembling channels through which stochastic information flows. This diagrammatic manipulation allows us to create a method which constructs networks by joining building blocks selected so that (a) they cover only basic processes; (b) it is scalable to large networks; (c) the mean and variance-covariance from the Pauli master equation form a closed system; and (d) given the initial probability distribution, no special boundary conditions are necessary to solve the master equation. The method aims to help with both designing new synthetic signaling pathways and quantifying naturally existing …
Exposure Of Fibrinogen And Thrombin To Nitric Oxide Donor Prolinonoate Affects Fibrin Clot Properties, Christine C. Helms, Shannon Kapadia, Anne C. Gilmore, Zhexi Lu, Swati Basu, Daniel B. Kim-Shapiro
Exposure Of Fibrinogen And Thrombin To Nitric Oxide Donor Prolinonoate Affects Fibrin Clot Properties, Christine C. Helms, Shannon Kapadia, Anne C. Gilmore, Zhexi Lu, Swati Basu, Daniel B. Kim-Shapiro
Physics Faculty Publications
Fibrin fibers form the structural backbone of blood clots. The structural properties of fibrin clots are highly dependent on formation kinetics. Environmental factors such as protein concentration, pH, salt, and protein modification, to name a few, can affect fiber kinetics through altered fibrinopeptide release, monomer association, and/or lateral aggregation. The objective of our study was to determine the effect of thrombin and fibrinogen exposed to nitric oxide on fibrin clot properties. ProliNONOate (5 [mu]mol/l) was added to fibrinogen and thrombin before clot initiation and immediately following the addition of thrombin to the fibrinogen solution. Resulting fibrin fibers were probed with …