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Full-Text Articles in Physical Sciences and Mathematics
An Autoencoder-Based Deep Learning Method For Genotype Imputation, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Zhe Luo, Chuan Qiu, Lan Juan Zhao, Kuan Jui Su, Qing Tian, Hui Shen, Huixiao Hong, Ping Gong, Xinghua Shi, Hong Wen Deng, Chaoyang Zhang
An Autoencoder-Based Deep Learning Method For Genotype Imputation, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Zhe Luo, Chuan Qiu, Lan Juan Zhao, Kuan Jui Su, Qing Tian, Hui Shen, Huixiao Hong, Ping Gong, Xinghua Shi, Hong Wen Deng, Chaoyang Zhang
Michigan Tech Publications
Genotype imputation has a wide range of applications in genome-wide association study (GWAS), including increasing the statistical power of association tests, discovering trait-associated loci in meta-analyses, and prioritizing causal variants with fine-mapping. In recent years, deep learning (DL) based methods, such as sparse convolutional denoising autoencoder (SCDA), have been developed for genotype imputation. However, it remains a challenging task to optimize the learning process in DL-based methods to achieve high imputation accuracy. To address this challenge, we have developed a convolutional autoencoder (AE) model for genotype imputation and implemented a customized training loop by modifying the training process with a …
A Mild Dyssynchronous Contraction Pattern Detected By Spect Myocardial Perfusion Imaging Predicts Super-Response To Cardiac Resynchronization Therapy, Xiao Hu, Zhiyong Qian, Fengwei Zou, Siyuan Xue, Xinwei Zhang, Yao Wang, Xiaofeng Hou, Weihua Zhou, Jiangang Zou
A Mild Dyssynchronous Contraction Pattern Detected By Spect Myocardial Perfusion Imaging Predicts Super-Response To Cardiac Resynchronization Therapy, Xiao Hu, Zhiyong Qian, Fengwei Zou, Siyuan Xue, Xinwei Zhang, Yao Wang, Xiaofeng Hou, Weihua Zhou, Jiangang Zou
Michigan Tech Publications
Background: Using single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) with phase analysis (PA), we aimed to identify the predictive value of a new contraction pattern in cardiac resynchronization therapy (CRT) response. Methods: Left ventricular mechanical dyssynchrony (LVMD) was evaluated using SPECT MPI with PA in non-ischemic dilated cardiomyopathy (DCM) patients with left bundle branch block (LBBB) indicated for CRT. CRT super-response was defined as LV ejection fraction (EF) ≥50% or an absolute increase of LVEF >15%. The LV contraction was categorized as the mild dyssynchronous pattern when the phase standard deviation (PSD) ≤ 40.3° and phase histogram …