Physical Sciences and Mathematics Commons^™

A Mild Dyssynchronous Contraction Pattern Detected By Spect Myocardial Perfusion Imaging Predicts Super-Response To Cardiac Resynchronization Therapy, Xiao Hu, Zhiyong Qian, Fengwei Zou, Siyuan Xue, Xinwei Zhang, Yao Wang, Xiaofeng Hou, Weihua Zhou, Jiangang Zou

Michigan Tech Publications

Background: Using single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) with phase analysis (PA), we aimed to identify the predictive value of a new contraction pattern in cardiac resynchronization therapy (CRT) response. Methods: Left ventricular mechanical dyssynchrony (LVMD) was evaluated using SPECT MPI with PA in non-ischemic dilated cardiomyopathy (DCM) patients with left bundle branch block (LBBB) indicated for CRT. CRT super-response was defined as LV ejection fraction (EF) ≥50% or an absolute increase of LVEF >15%. The LV contraction was categorized as the mild dyssynchronous pattern when the phase standard deviation (PSD) ≤ 40.3° and phase histogram …