Physical Sciences and Mathematics Commons^™

Simian Immunodeficiency Virus Infection Mediated Changes In Jejunum And Peripheral Sars-Cov-2 Receptor Ace2 And Associated Proteins Or Genes In Rhesus Macaques, Nongthombam Boby, Xuewei Cao, Kelsey Williams, Shiva Kumar Goud Gadila, Monica N. Shroyer, Peter J. Didier, Sudesh K. Srivastav, Arpita Das, Kate Baker, Qiuying Sha, Bapi Pahar

Michigan Tech Publications

Angiotensin converting enzyme-2 (ACE2) and associated proteins play a pivotal role in various physiological and pathological events, such as immune activation, inflammation, gut barrier maintenance, intestinal stem cell proliferation, and apoptosis. Although many of these clinical events are quite significant in SIV/HIV infection, expression profiling of these proteins has not been well reported. Considering the different pathological consequences in the gut after HIV infection, we hypothesized that the expression of ACE2 and associated proteins of the Renin-angiotensin system (RAS) could be compromised after SIV/HIV infection. We quantified the gene expression of ACE2 as well as AGTR1/2, ADAM17, and TMPRSS2, and …