Physical Sciences and Mathematics Commons^™

Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics, Thomas Dipuma

Master's Theses

N-Succinyl-L,L-2,6-Diaminopimelic Acid Desuccinylase (DapE) is a bacterial enzyme located in the lysine biosynthetic pathway of all Gram-negative and most Gram-positive species of bacteria including the notorious ESKAPE pathogens, or pathogenic strains of bacteria that have developed significant levels of resistance to currently available antibiotics. As a means to combat this challenge of growing antimicrobial resistance, we have identified the bacterial enzyme DapE as a conserved, novel enzymate target within these resistant bacterial strains,as DapE is responsible for the production of m-DAP and lysine which are ultimately employed in bacterial cell wall synthesis. The overall aim of this research is to …

Constructing Planetary Citizens Through Ecopedagogy In U.S. Social Studies Standards, Madeline Anne Rainey

Master's Theses

The world is in the age of the Anthropocene, where humans are impacting the environment to disastrous effects. The capitalist economy, promoting neoliberal policies of mass consumption, has exacerbated the world's environmental deterioration and social inequity. The rights and responsibilities people hold have been rapidly changing with the fourth industrial revolution. Globalization and Information and Communications Technology (ICT) have further expanded notions of citizenship. While there have been numerous attempts to bring the environment into schools, it has not emphasized what this crisis deserves. Ecopedagogy, as a critical theory, explicitly examines the interplay between environmental and social problems and challenges …

Synthesis And Characterization Of Ruthenium Complexes And Their Potential And Photosensitizers For Photodynamic Therapy, Keit Dine

Master's Theses

Cancer is one of the leading causes of death in the world with over 10 million people dying of the disease every year. Inorganic complexes supported by platinum metal centers are often used in cancer treatment. However, these complexes lack selectivity for tumor cells. As such, other alternatives to platinum have been explored. Ruthenium (Ru) complexes are one of the most promising candidates due to their ability to be used as photosensitizing drugs in photodynamic therapy. Herein, we report the design, synthesis, and characterization of two novel ruthenium-based complexes. One compound is a Ru(II) homoleptic complex, while the other is …

Randomness Distillation To Improve Key Quality For Context-Based Authentication Schemes, Jackson West

Master's Theses

Context-based authentication is a method for transparently validating another device’slegitimacy to join a network based on location. Devices can pair with one another by continuously harvesting environmental noise to generate a random key with no user involvement. However, there are gaps in our understanding of the theoretical limitations of environmental noise harvesting, making it difficult for researchers to build efficient algorithms for sampling environmental noise and distilling keys from that noise. This work explores the information-theoretic capacity of context-based authentication mechanisms to generate random bit strings from environmental noise sources with known properties. Using only mild assumptions about the source …

Exposing The Effects Of Reaction Cavity In Solid-Phase Reaction Kinetics, Michael Carr

Master's Theses

Reactivity of molecular solids is governed by topochemical considerations, where minimizedmolecular movement dictates both product identity and kinetics. This Thesis explores the central role reaction cavity plays in the topochemical principle by using the highly varied cavities formed by the different facets of a tetracene crystal. The relative rates for ten different reaction cavities were measured via energy dispersive X-ray spectroscopy for the reaction of tetracene with vapors of maleic anhydride. Variance in cavities resulted in Diels-Alder reaction rates that differed by as much as a factor of 2.6. Effects were understood via molecular dynamic simulations which modeled the approach …

Predicting Drug Misuse Status Using Machine Learning On Electronic Health Records, Robert Arnold Kania

Master's Theses

Substance misuse is a major problem in the world. in 2014, as many as 52,404 deaths in the US were caused by drug overdoses. in 2001, the monetary cost of drug misuse has been estimated to be 414 billion dollars. in this work, we explore the use of different machine learning algorithms in the prediction of cocaine misuse using structured and unstructured data found in electronic health records. These records contain various attributes that can help with this prediction, including but not limited to chart text data, previous diagnoses of certain diseases and information about the area the patient lives …

Wayfinder Application For Autistic Occupational Assistance, Nathaniel Edward Hishon

Master's Theses

Employment among autistic individuals is an area of noted difficulty, with an employment rate well below the general population [1]. Several barriers attributed to autistic unemployment, including difficulties communicating with employers and social interactions with coworkers, obsessive adherence to routine, and trouble organizing and completing workplace tasks, are also attributed to challenges in maintaining employment [2]. Several studies have concluded that long-term employment support is necessary to acquire and maintain autistic employment [3]. The noted benefit of intensive job training, such as access to job coaches, indicates the need for further support to help autistic individuals complete workplace tasks and …

Using Software-Defined Networking And Openflow Switching To Reroute Network Traffic Dynamically Based On Traffic Volume Measurements, Ihab Al Shaikhli

Master's Theses

Traditional switching and routing have been very effective for network packet delivery but does create some constraints. for example, all packets from a given source to a given destination must always take the same path. Within a traditional Ethernet network, a tree topology must be used. Software-Defined Networking (SDN) has the potential to bypass this tree-topology limitation by placing the control of the switches and their forwarding tables under a central device called a controller. SDN also allows for sets of controllers. the controller can identify individual network flows and issue commands to the switches to, in effect, assign individual …

Opioid Misuse Detection In Hospitalized Patients Using Convolutional Neural Networks, Brihat Sharma

Master's Theses

Opioid misuse is a major public health problem in the world. In 2016, 11.3 million people were reported to misuse opioids in the US only. Opioid-related inpatient and emergency department visits have increased by 64 percent and the rate of opioid-related visits has nearly doubled between 2009 and 2014. It is thus critical for healthcare systems to detect opioid misuse cases. Patients hospitalized for consequences of their opioid misuse present an opportunity for intervention but better screening and surveillance methods are needed to guide providers. The current screening methods with self-report questionnaire data are time-consuming and difficult to perform in …

Mechanistic Investigations Of The Iron(Iii)-Catalyzed Carbonyl-Olefin Metathesis Reaction, Susan Phan

Master's Theses

Iron(III)-catalyzed carbonyl-olefin ring-closing metathesis represents a new approach toward the assembly of molecules traditionally generated by olefinˆ’olefin metathesis or olefination. Herein, we report detailed synthetic, spectroscopic, kinetic, and computational studies to determine the mechanistic features imparted by iron(III), substrate, and temperature to the catalytic cycle. These data are consistent with an iron(III)-mediated asynchronous, concerted [2+2]-cycloaddition to form an intermediate oxetane as the turnover-limiting step. Fragmentation of the oxetane via Lewis acid-activation results in the formation of five- and six-membered unsaturated carbocycles.

A Study Into The Feasibility Of Using Natural Language Processing And Machine Learning For The Identification Of Alcohol Misuse In Trauma Patients, Andrew Phillips

Master's Theses

Alcohol misuse is a leading cause of premature death in the United States, with nearly a third of trauma patients found to have elevated blood alcohol levels upon admission. However, timely intervention has been shown to reduce this. It is thus important to be able to quickly screen patients to identify alcohol misuse. Many medical centers use standardized questionnaires to identify alcohol misuse, but since these instruments are not usually a part of routine care, there are many cases where it is not done.

In this study, large quantities of notes were processed with natural language processing and machine learning …

Toddler Activity Recognition Using Machine Learning, Pinky Sindhu

Master's Theses

Pinky Sindhu

Loyola University Chicago

TODDLER ACTIVITY RECOGNITION USING MACHINE LEARNING

Toddlers behave differently than adults, to say the least. It is valuable to accurately measure the specific types of physical activity (PA) in toddlers; such information can be analyzed to predict future health prospects in relation to conditions like obesity.

We attached ActiGraph accelerometers to the wrist and waist of toddlers and recorded PAs. Toddlers were videotaped, and their movements were annotated as 20 specific activities. These activities were classified into 3 summary activity intensities including sedentary, light intensity PA (LPA), and moderate to vigorous intensity PA (MVPA).

Automated …

Real-Time Fall Detection And Response On Mobile Phones Using Machine Learning, Ilona Shparii

Master's Theses

Falls are common and often dangerous for groups with impaired mobility, like the elderly or people with lower limb amputations. Finding ways of minimizing the frequency or impact of a fall can improve quality of life dramatically. When someone does fall, real-time detection of the fall and a long-lie can trigger fast medical assistance. Such a system can also collect reliable data on the nature of real-world falls that can be used to better understand the circumstances, to aid in prevention efforts. This work has been to develop a real-time fall tracking system specifically for subjects with lower limb amputations. …

A Mobile App Illustrating Sensory Neural Coding Through An Efficient Coding Of Collected Images And Sounds, Xiaolu Zhao

Master's Theses

Sensory neuroscience in the early auditory and visual systems appears distinct not

only to outside observers, but to many trained neuroscientists as well. However, to a computational neuroscientist, both sensory systems represent an efficient neural coding of information. In fact, on a computational level it appears the brain is using the same processing strategy for both senses - the same algorithm with just a change in inputs. Insights like this can greatly simplify our understanding of the brain, but require a significant computational background to fully appreciate. How can such illuminating results of computational neuroscience be made more accessible to …

Developing Integral Ecologists: Description And Analysis Of The State Of Environmental Education At Jesuit High Schools In Light Of Religious Ecological Commitments And Science Education Research, Philip Nahlik Nahlik

Master's Theses

This research responds to numerous calls to focus more immediately and deeply on environmental education in the context of local communities. Jesuit high schools offer a rich network to study this movement, as schools with long histories of scholarly and moral concerns for forming students to think about and act on worldwide problems. The key research question is: How can science education research inform environmental education in these schools? The research methodology includes data collection and analysis of publicly-accessible website data, phone interviews with teachers, and a literature review of science education research. Recommendations are given for vertically aligning the …

Building And Optimizing A Spectroelectrochemical System For The Study Of Shewanella Putrefaciens, Jonathan Muscolino

Master's Theses

Shewanellaceae are among the most widely studied electroactive microorganisms. This study reports on Shewanella putrefaciens under anaerobic conditions during applied potential while monitored by spectroscopy. The attachment of the microbe Shewanella putrefaciens onto an indium tin oxide electrode was found to occur after 2 hr of +0.2 V applied potential. Microbial detachment occurred with a 5 mV/s scan rate cyclic voltammogram from +0.2 V to -0.5 V to +0.2 V. This was confirmed through use of a spectroelectrochemical apparatus utilizing a standard 3 electrode setup with evanescent wave spectroscopy.

Metrics Dashboard Services: A Framework For Analyzing Free/Open Source Team Repositories, Fnu Shilpika

Master's Theses

Software engineering as practiced today (especially in the industry) is no longer about the stereotypical monolithic life cycle processes (e.g. waterfall, spiral, etc.) found in most software engineering textbooks. These heavyweight methods historically have impeded progress for small/medium sized development teams owing to their inherent complexity and rather limited data collection strategies that predominated the 1980s until relatively recently in the mid-2000s. The discipline and practice of software engineering includes software quality, which has an established theoretical foundation for doing software metrics. Software metrics are a critical tool which provide continuous insight to products and processes and help build reliable …

Activity Recognition For Incomplete Spinal Cord Injury Subjects Using Hidden Markov Models, Pichleap Sok

Master's Theses

Successful activity recognition in patients with motor disabilities can improve patient care by providing researchers and clinicians with valuable information on patient movements and quality of life in real-world settings. Understanding the everyday activities of patients is important for rehabilitation. For researchers, having convenient, objective, and continuous data can drastically improve outcome measures to better compare therapies, and ultimately make recommendations. For clinicians, individual assessment of compliance and outcomes outside the clinic can be more objective, permitting much more tailored recommendations to patients. Most importantly, for individual patients, activity recognition can make this improved health care possible by simply having …

The Influence Of Eastern Oyster (Crassostrea Virginica) Reef Restoration On Nitrogen Cycling In A Eutrophic Estuary., Michael Hassett

Master's Theses

Oysters (Crassostrea virginica) are functionally extinct in the urbanized Hudson-Raritan estuary (HRE) in New York City, however, oyster restoration is promoted to mitigate nitrogen (N) pollution via oysters' filtration and excretion. Seasonally, I took 12 sediment cores (45 cm2) adjacent to and 10 m away from a recently constructed reef in the HRE. Cores were incubated in flow-through chambers with site water containing (1) no amendments, (2) 15N-ammonium, or (3) 15N-nitrate, from which I calculated coupled nitrification-denitrification and direct denitrification as isotope-enriched N2. Coupled denitrification was minimal at all sites while direct denitrification was elevated near the reef, suggesting organic …

Evaluation Of The Performance Of Non-Covalent Molecular Mechanical Models For Zn2+ And Mg2+ Metal Ions, Maria Magdalena Kamm

Master's Theses

Computer simulations using molecular dynamics (MD) on classical molecular mechanical

(MM) interatomic potentials can provide valuable information and quantitative

predictions about these systems. In MD calculations binding free energies of ions to

host molecules can be studied if correct ion solvation free energies in aqueous solution

are obtained. However, no MM models exist that parametrize various Zn2+ and

transition metals consistently and consider both structural and thermodynamic data

simultaneously.

The first part of our work focused on MD free energy perturbation (FEP) simulations

to derive MM interaction parameters for Zn2+ and Mg2+ ions in aqueous

solution. To obtain these parameters …

Novel Synthetic Route To 5-Substituted Indoles, Helen Y. Chen

Master's Theses

No abstract provided.

Molecular Dynamics Of Crosslinked And Normal Hemoglobins, Liang Zhao

Master's Theses

No abstract provided.

The Application Of Matrix Assisted Laser Desorption Ionization Time Of-Flight Mass Spectrometry (Maldi Tof Ms) For Dna Adducts And Cross-Linked Hemoglobin Analysis, Xiaomei Gu

Master's Theses

No abstract provided.

Effects Of Perinatal Exposure To Cocaine On Sexually Differentiated Gonadotropin Regulation In Rats, Jihun M. Lee

Master's Theses

No abstract provided.

Molecular Dynamics Of The Hammerhead Ribozyme, Vasant T. Gandhi

Master's Theses

No abstract provided.

Syntheses Of Monometallic And Bimetallic Pd(Ii) Catalysts Supported On Polymer Surface And Their Applications In Organic Syntheses, Qin Jian Yu

Master's Theses

No abstract provided.

Electrochemical Cleavage Of Phenylsulfones, Joseph E. Lohr

Master's Theses

No abstract provided.

Electrochemical, Chromatographic, And Spectrometric Studies Of An Osmium Containing Polymer, Lawrence John Rhodes

Master's Theses

No abstract provided.

Studies On The Cyclization Of Cis-1,4-Dichloro-2-Butene With Sodium Dialkylmalonates, Hovis M. E. Imade

Master's Theses

No abstract provided.

Electrochemical Studies Of Hemoglobin And Cross-Linked Hemoglobin, Ayoola O. Alabi

Master's Theses

No abstract provided.