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Full-Text Articles in Physical Sciences and Mathematics
Development Of Nucleic Acid Diagnostics For Targeted And Non-Targeted Biosensing, Christopher William Smith
Development Of Nucleic Acid Diagnostics For Targeted And Non-Targeted Biosensing, Christopher William Smith
Legacy Theses & Dissertations (2009 - 2024)
The field of nucleic acid technology is rapidly expanding with new impactful discoveriesbeing made each year. Starting from the discovery of the double-helix structure, cloning, gene editing, polymerase chain reaction (PCR), CRISPR technology, and even the late mRNA vaccines; nucleic acid technology is at the forefront of improving medicine. Nucleic acid technology is extremely versatile due to its easy programmability, automated cheap synthesis, and even its catalog for numerous chemical modifications that can be used to alter structure stability. For example, the number of permutations that can be made with DNA just by altering the code for adenine (A), cytosine …
System Measurements For X-Ray Phase And Diffraction Imaging, Erik Wolfgang Tripi
System Measurements For X-Ray Phase And Diffraction Imaging, Erik Wolfgang Tripi
Legacy Theses & Dissertations (2009 - 2024)
In medical imaging, X rays are used to look inside the body to find fractures in bones, abnormal masses, cavities in teeth, and so on. What makes X rays so good at looking at these types of structures is the X ray’s penetration power. When imaging soft tissue to search for tumors, X-ray images tend to have difficulty performing well. The reason for this is that the background structures, such as fat or fibro glandular tissue have similar absorption coefficients as the tumor. Mammography tends to have a high false positive rate and can miss tumors entirely as well. There …
Chemically And Biologically Responsive Nanoparticle Systems For Biomarker Detection And Combination Cancer Therapy, Neil M. Robertson
Chemically And Biologically Responsive Nanoparticle Systems For Biomarker Detection And Combination Cancer Therapy, Neil M. Robertson
Legacy Theses & Dissertations (2009 - 2024)
The uniqueness and expression of miRNAs as biomarkers in certain cancers has the potential to radically alter the detection, and therefore the treatment, of the disease. Not only are current detection methods time consuming, and not sensitive enough for biomedical applications, but these small RNAs have yet to be fully utilized in treatment. By utilizing different nanomaterials we aimed to create novel nanodevices for the early, sensitive and specific detection of these biomarkers in a minimally invasive way and develop dual drug releasing nanoparticles, which are entirely controllable, to aid in the treatment of resistant cancer phenotypes.
Developing A Weibull Model Extension To Estimate Cancer Latency Times, Diana L. Nadler
Developing A Weibull Model Extension To Estimate Cancer Latency Times, Diana L. Nadler
Legacy Theses & Dissertations (2009 - 2024)
More than one-third of all Americans will be diagnosed with cancer sometime in their lives. Though their illness may be invisible now, it presents a great, and largely unexamined, opportunity to find and treat their cancers early. Early detection represents one of the most promising approaches to reduce the growing cancer burden by identifying cancer while it is localized and curable, preventing not only mortality, but also reducing morbidity and costs.
Modeling Of Megavoltage And Low Energy Focused X-Ray Beams Using Mcnp5, Hassan Abbas
Modeling Of Megavoltage And Low Energy Focused X-Ray Beams Using Mcnp5, Hassan Abbas
Legacy Theses & Dissertations (2009 - 2024)
In this thesis 6 and 18 MV photon beams for a Varian linear accelerator were simulated using a general purpose Monte Carlo code MCNP5 (Monte Carlo N-Particle Transport Code). The potential of MCNP5 is explored to calculate the dose in high dose gradient regions. In addition, MCNP5 was used to model another geometry, low energy focused x ray beams created with polycapillary optics, to explore their potential to provide a different skin-sparing technique for radiation therapy.