Physical Sciences and Mathematics Commons^™

Microsatellite Instability In Squamous Cell Carcinoma And Lichen Sclerosus Of The Vulva, Sidney Joseph Marlborough

LSU Master's Theses

The usefulness of detecting genomic instability in the form of microsatellite instability (MSI) has been examined in a number of cancers. Squamous cell carcinoma (SCC) and adjacent normal and lichen sclerosis (LS) samples were taken from patients with radical vulvectomies. Vulvar SCC samples were compared with adjacent normal samples using four oligonucleotide markers (BAT-25, BAT-26, D10S208 and D10S587) found to be informative with other carcinomas. Using polymerase chain reaction techniques, 30 vulvar SCC DNA samples were examined for MSI. BAT-26 displayed the highest level of MSI and was considered to be the most sensitive marker in studying vulvar SCC. There …