Physical Sciences and Mathematics Commons^™

The Effects Of Polychlorinated Biphenyls (Pcbs) On Nerve Growth Factor (Ngf) In The Developing Frog, Xenopus Laevis, Cari Delong

Honors Theses

Polychlorinated biphenyls are ubiquitous, persistent environmental contaminants that cause a variety of adverse health effects wildlife and humans. PCBs are the major contaminant in the Kalamazoo River Superfund Site, in which the Environmental Institute is funded to study. Projects at the Environmental Institute are focused on developing molecular biotechnology tools that will improve environmental risk assessment. Previous acute studies involved the exposure of developing tadpoles, Xenopus laevis to PCBs through aquarium water in order to measure gene expression. Nerve growth factor (NGF) gene expression showed changes in these previous studies. NGF is a neurotrophic factor that regulates the growth and …