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Classifying Pretzel Links Obtained By Strong Fusion, Jonathan Homan
Classifying Pretzel Links Obtained By Strong Fusion, Jonathan Homan
Honors Theses
A link is a collection of circles embedded into 3-dimensional space. Pretzel links are an important family of links which comprises those links that fit a general form that includes many of the most common links. The strong fusion of a link joins two components of the link via a band and adds an unknotted circle about the band [4]; this naturally arises in the study of concordance and has been used to model biological phenomena such as site specific recombination in DNA [2]. Here we present a complete and original classification of those pretzel links which can be obtained …
Attempted Synthesis & Antibacterial Properties Of Apt-6k Against Ndm-1 K. Pneumoniae, Alec Bofetiado
Attempted Synthesis & Antibacterial Properties Of Apt-6k Against Ndm-1 K. Pneumoniae, Alec Bofetiado
Honors Theses
NDM-1 K. pneumoniae is a highly resistant bacterial organism that is capable of causing debilitating nosocomial infections in immunocompromised patients. Only "last-resort" antibiotics--such as colistin--work against this organism. Therefore, new antibiotics are needed to help fight against these types of infections. APT-6K is a novel compound that was demonstrated to be effective against MRSA with nanomolar concentrations in a prior study. Novel methods of APT-6K synthesis and its testing for antibiotic effects against NDM-1 K. pneumoniae were attempted in this research. APT-6K synthesis was unsuccessful. Commercially-prepared APT-6K also did not demonstrate growth inhibition against NDM-1 K. pneumoniae nor against a …