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Full-Text Articles in Physical Sciences and Mathematics
Population Variation In Fossil Graptolites: A Quantitative Study Based On Single Species Assemblages, Elliott Matthias Mazur
Population Variation In Fossil Graptolites: A Quantitative Study Based On Single Species Assemblages, Elliott Matthias Mazur
Honors Theses
There are several different types of variation in populations of fossil organisms. These include intra-specific (population) variation, evolutionary variation (specimens on a slab accumulating over thousands of years), and preservational variation. An understanding of the extent and type of variation present in a population is fundamental to biological and paleontological studies. This study examines several populations of fossil graptolites from which population variation can be studied without the influence of the other types, and includes several types of morphometric analyses to examine population variation in several species of fossil graptolites. These analyses include isolating three dimensionally preserved specimens from limestone, …
Classifying The Functionality Of Primosome Protein A In Deinococcus Radiodurans, Jacob Boone
Classifying The Functionality Of Primosome Protein A In Deinococcus Radiodurans, Jacob Boone
Honors Theses
Deinococcus radiodurans is an extremophile bacterium with the capacity to withstand tremendous DNA damage that causes disruption of replisome complex activity. The efficiency of origin-independent replisome reloading directly correlates to effectiveness of DNA damage coping strategies, and remains largely undefined in D. rad primosome components. Investigation of D. rad PriA as a helicase protein was conducted to determine if PriA could be classified as a fossilized helicase. This project tested the three functions of known helicases by comparing E. coli and D. rad PriA. DNA binding, DNA unwinding, and ATP hydrolysis assays were performed on both proteins separately and results …
Synthesis And Characterization Of Three Unique Mono-Metallic Lanthanide Complexes, Jasminder S. Grewal
Synthesis And Characterization Of Three Unique Mono-Metallic Lanthanide Complexes, Jasminder S. Grewal
Honors Theses
Three unique lanthanide complexes of formula Ln(tdh)3dpp (where Ln = Eu3+, Tb3+or Nd3+; tdh = 1,1,1- trifluoro-5,5-dimethyl-2,4-hexanedione and dpp = 2,3-Bis(2-pyridyl)pyrazine) were structurally characterized. X-ray quality crystals were grown through slow evaporation in a solution of concentrated ethyl acetate and hexanes. Each of the metals are eight coordinate, with 6 oxygen atoms from the tdh ligand and two nitrogen atoms from the dpp. Specifically, the nitrogen from 1-pyridyl group and the 1-pyrazine group coordinate to the lanthanide metal. Luminescent studies were performed on all three compounds. The Eu and Tb complexes were able to emit light in the visible region …
Investigating Bacterial Replication Restart: Can D.Rad Pria Load D.Rad Dnab Onto Dna Forks With A Leading Strand Gap?, Michael Ryan
Investigating Bacterial Replication Restart: Can D.Rad Pria Load D.Rad Dnab Onto Dna Forks With A Leading Strand Gap?, Michael Ryan
Honors Theses
The bacteria Deinococcus radiodurans (D. rad) is able to survive multiple double stranded breaks to its DNA with no detriment to its health as its genome can be fully repaired in a matter of hours. During bacterial DNA replication, points of DNA damage can cause replication to cease, requiring an origin independent replisome loading pathway to resume the replication. This pathway is called replication restart , a highly conserved pathway in bacteria. In the E. coli replication restart pathway primosome proteins function by binding to the DNA fork and facilitating the loading of the DnaB helicase onto the replication fork. …
Synthesis And Purification Of A Nucleoside Platinum Complex That Promotes Dna Cross-Linking, Ryan Spear
Synthesis And Purification Of A Nucleoside Platinum Complex That Promotes Dna Cross-Linking, Ryan Spear
Honors Theses
Cancer is a deadly and ever present disease in humans and its treatment has become a focus of many types of research. This project was designed to synthesize a platinum complex that will cross-link DNA and in turn cause cell death for rapidly dividing cells (usually cancer cells). The target compound strongly resembled the structure of a nucleic acid, thymidine. Further, nucleic acids are extremely important to cell life and cell membranes have transporters specific for them. Therefore, the purpose to exploring this new platinum complex was to create compound that a cell can easily transport inside its cell and …
Synthesis And Characterization Of A Tetra-Ruthenated Naphthylbiliverdin, Ashley M. Berding
Synthesis And Characterization Of A Tetra-Ruthenated Naphthylbiliverdin, Ashley M. Berding
Honors Theses
A new naphtylbiliverdin compound has been synthesized which offers intense absorption with the photodynamic therapy window (600 nm – 850 nm). The compound has been characterized by proton NMR, high resolution electrospray mass spectrometry, elemental analysis, and UV/vis spectroscopy. Coordination of four ruthenium(II) polypyridyl complexes was accomplished by standard procedures. The new tetra-ruthenated naphthylbiliverdin was characterized by elemental analysis. Cyclic voltammetry measurements reveal that all four ruthenium moieties are coordinated to the pyridyl groups of the biliverdin compound. The intense metal to ligand charge transfer (MLCT) bands of the peripheral ruthenium groups overshadow the absorption due to the biliverdin compound; …
Exploring Data-Driven Electricity Feedback On Energy Conservation Behavior In The University Of Dayton Student Neighborhood, Daniel R. Esposito
Exploring Data-Driven Electricity Feedback On Energy Conservation Behavior In The University Of Dayton Student Neighborhood, Daniel R. Esposito
Honors Theses
In general, homeowners do not have a concrete idea of how much energy their houses are using at any given moment. This energy “invisibility” is thought to be a barrier toward people adopting more sustainable behaviors. This study involves installing energy monitors in houses in the University of Dayton student neighborhood to analyze two important questions: whether the monitors teach students about the relationship between their activities and energy consumption, and whether the monitors influence students to adjust their household behaviors. Due to complications with and uncertainties in the data, quantitative conclusions could not be drawn. Fortunately, data collected from …
Design And Characterization Of Photoresponsive Supramolecular Aggregates, Julie A. Fitz
Design And Characterization Of Photoresponsive Supramolecular Aggregates, Julie A. Fitz
Honors Theses
Supramolecular chemistry concerns the manner in which molecular building blocks associate via non-covalent interactions and form aggregates. The particular building block in this research is a photoresponsive molecule 4,4’-azobenzene dicarboxylic acid (ADA), a molecule that isomerizes reversibly around an N-N double bond upon irradiation with different wavelengths of light. The large structural changes in the molecule that result from isomerization have the potential to modulate the properties of a supramolecular aggregate. ADA was studied under a variety of environmental conditions for the purpose of understanding aggregation behavior and geometries. A UV-Vis and Circular Dichroism (CD) spectroscopic study of ADA showed …
Photoreactions Of A Water Soluble Poly-Isoquinolpyrrole With Plasmid Dna, Gregory Versteeg
Photoreactions Of A Water Soluble Poly-Isoquinolpyrrole With Plasmid Dna, Gregory Versteeg
Honors Theses
With the goal of creating a porphyrin we reacted isoquinol pyrrole, p-fluorobenzaldehyde, and boron trifluoride etherate under appropriate conditions. Instead of a porphyrin being synthesized, we created polyisoquinol pyrrole in high yield and with great absorption properties around 600nm. We characterized this compound via UV/vis spectroscopy, proton NMR, and electrochemistry. The compound was then reacted with [Ru(bipy)2Cl2] to create a cationic compound and this molecule was tested as a possible photosensitizer for photodynamic therapy (PDT) but it was unable to photocleave plasmid DNA above 550nm. The original compound was then methylated and this new compound was also tested as a …