Physical Sciences and Mathematics Commons^™

Parweb: A Front-End Interface For Cluster Computing., Jacob Potter

Honors Theses

The High Performance Computational Science Laboratory at Western Michigan University operates a cluster of systems for use by students, professors, and professional researchers. Currently users that want to access the cluster, known as “Thor”, require knowledge of the Unix/Linux command line. They also require knowledge of operating a piece of software known as TORQUE to correctly achieve results from the High Performance Computing Lab.

The Web User Interface Framework for High Performance Cluster Computing alleviates the need for intimate knowledge of a command line interface, and replaces the current interaction interface with a more user friendly and graphical oriented system. …

Functional Variants Of Metal-Binding Domains 5 And 6 Of The Human Wilson Protein, Sandra Weitzner

Honors Theses

Wilson's disease is caused by mutations in atp7b, a gene that encodes a copper-transporting P_1B-type ATPase, otherwise known as the Wilson protein. Over 300 different mutations cause Wilson's disease, and we focused on missense mutations occurring in the 650 amino acid N-terminus of the Wilson protein. This portion of the protein includes six metal-binding domains that function to azquire Cu(I) from the cytosol, prior to passing it through the ATP-driven membrane-spanning pump. Of particular interest are metal-binding domains 5 and 6 (WLN5-6) since we know that they are absolutely required for function of the enzyme. Several missense mutations …