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Photodynamic Cancer Therapy A Study Of The Photochemical Properties Of Meso-Tetra (2,3,4-Trifluorophenyl) Porphyrin And Meso-Tetra (2,3,5,6-Tetrafluorophenyl) Porphyrin, Delanie L. Newberry
Photodynamic Cancer Therapy A Study Of The Photochemical Properties Of Meso-Tetra (2,3,4-Trifluorophenyl) Porphyrin And Meso-Tetra (2,3,5,6-Tetrafluorophenyl) Porphyrin, Delanie L. Newberry
Honors College Theses
Photodynamic therapy(PDT) is a type of cancer treatment that utilizes photosensitive molecules that absorb photons and use that energy to create cytotoxic molecules. Porphyrins are photosensitive compounds that can be used selectively at the site of cancerous tumors. Their selectivity is due to the fact the porphyrins are generally not toxic in absence of light; in the presence of light, the drug will be activated to produce the cytotoxic molecule, singlet oxygen(1O2 ). 9,10 diphenyl anthracene(DPA) was used to simulate the cancer cells and monitor how effective the porphyrin was in creating 1O2, because DPA reacts with 1O2 form diphenyl …
Novel Photodynamic Therapy Agents: Biochemical Analysis, Eboni D. Pullen
Novel Photodynamic Therapy Agents: Biochemical Analysis, Eboni D. Pullen
Honors College Theses
Bioinorganic photochemistry is a rapidly advancing research area in the field of bioinorganic chemistry. This project seeks to build upon the growing field by synthesizing and analyzing new photodynamic therapy (PDT) agents. There are three major generations of PDT agents. The first generation consists of chemically modified natural hematoporphyrins, which are not of great interest in the phototherapeutic field due to their low distinguishability between tumor cells and healthy cells, and extended skin photosensitivity in patients. The second generation consists of organic dyes, aromatic hydrocarbons, polypyrolics complexes, and semi-conductors, but is also not of much interest due to the same …