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Articles 1 - 7 of 7
Full-Text Articles in Physical Sciences and Mathematics
Exploring The Relationship Of Mbd1 Protein Binding Cpg Sites Of Methylated Dna, Shelby L. Scherer
Exploring The Relationship Of Mbd1 Protein Binding Cpg Sites Of Methylated Dna, Shelby L. Scherer
Honors College Theses
Methylated DNA binding (MBD) proteins control transcriptional regulation by binding methylated DNA at CpG islands to modulate transcriptional activation and silencing of specific genes such as tumor suppressors. The goal is to explore the structure/function relationship between MBD proteins and methylated DNA recognition. By synthesizing the methylated DNA binding region of the MBD1 protein, binding studies test the peptide’s affinity and specificity for methylated DNA. Fluorescence, circular dichroism, and thermal denaturation techniques are utilized to determine the binding affinities and structures of peptides. Studies of peptide mutations can monitor the effectiveness of methylated DNA binding compared to the original peptide. …
Drawing Numbers And Listening To Patterns, Loren Zo Haynes
Drawing Numbers And Listening To Patterns, Loren Zo Haynes
Honors College Theses
The triangular numbers is a series of number that add the natural numbers. Parabolic shapes emerge when this series is placed on a lattice, or imposed with a limited number of columns that causes the sequence to continue on the next row when it has reached the kth column. We examine these patterns and construct proofs that explain their behavior. We build off of this to see what happens to the patterns when there is not a limited number of columns, and we formulate the graphs as musical patterns on a staff, using each column as a line or space …
Mathematical Models For Infectious Disease Transmission With Stochastic Simulation Of Measles Outbreaks, Valerie Welty
Mathematical Models For Infectious Disease Transmission With Stochastic Simulation Of Measles Outbreaks, Valerie Welty
Honors College Theses
As they are the leading cause of death among children and adolescents worldwide, it is of extreme importance to control the spread of infectious diseases. Information gained from mathematical modeling of these events often proves quite useful in establishing policy decisions to accomplish this goal. Human behavior, however, is quite difficult to recreate when using equations with pre-determined results, such as deterministic differential equations often used with epidemic models. Because of this, the focus of the research was to create a simulation of an outbreak, specifically of measles, by using an imaginary population experiencing simulated stochastic events on a discrete …
Web Scraping The Easy Way, Yolande Neil
Web Scraping The Easy Way, Yolande Neil
Honors College Theses
Web scraping refers to a software program that mimics human web surfing behavior by pointing to a website and collecting large amounts of data that would otherwise be difficult for a human to extract. A typical program will extract both unstructured and semi-structured data, as well as images, and convert the data into a structured format. Web scraping is commonly used to facilitate online price comparisons, aggregate contact information, extract online product catalog data, extract economic/demographic/statistical data, and create web mashups, among other uses. Additionally, in the era of big data, semantic analysis, and business intelligence, web scraping is the …
Carinata Fame Production Process And Biofuel Oxidation, Benoit Kindo
Carinata Fame Production Process And Biofuel Oxidation, Benoit Kindo
Honors College Theses
In this experiment, the contribution of a standard production method for biofuels on their oxidative stability was investigated. Peroxide values were measured at different steps of the production process of Brassica carinata and peanut-based biofuels. The washing and drying steps in this production method showed significant increases in peroxide values for both biofuels and was identified as a major contributor of biofuel oxidation. Further analyses of the physical and thermal properties showed a more pronounced affect in the biofuel from Bassica carinata, and indicated an unusual composition much higher in saturated fatty acids much longer than those found in peanut. …
Black-Scholes Equation And Heat Equation, Charles D. Joyner
Black-Scholes Equation And Heat Equation, Charles D. Joyner
Honors College Theses
First, we present and define the Black-Scholes equation which is used to model assets on the stock market. After that, we derive the heat equation that describes how the temperature increases through a homogeneous material. Finally, we detail how the two equations are related. We introduce and relate the Black-Scholes equation and Heat Equation.
The Study Of Nf-Κb Peptide Mimics And How Proteins Bind Dna, Allee M. Murray
The Study Of Nf-Κb Peptide Mimics And How Proteins Bind Dna, Allee M. Murray
Honors College Theses
The protein complex nuclear factor kappa B (NF-κB) is widely considered to be one of the most influential transcription factors when studying cellular functions. Peptide mimics of NF-κB aim to inhibit DNA binding in order to displace the natural transcription factor, therefore inhibiting transcription and translation. In theory, NF-κB is not the problem; the real problem lies in directing the synthesis and expression of harmful proteins. In conjunction with this, the project aims to study NF-κB and its structure and function to determine what criteria are important for the binding of DNA in order to design a peptide that comes …