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Articles 1 - 8 of 8

Full-Text Articles in Physical Sciences and Mathematics

Structural Mimicry In Class A G Protein-Coupled Receptor Rotamer Toggle Switches, Sean D. Mcallister, Dow P. Hurst, Judy Barnett-Norris, Diane L. Lynch, Patricia H. Reggio, Mary E. Abood Nov 2004

Structural Mimicry In Class A G Protein-Coupled Receptor Rotamer Toggle Switches, Sean D. Mcallister, Dow P. Hurst, Judy Barnett-Norris, Diane L. Lynch, Patricia H. Reggio, Mary E. Abood

Faculty and Research Publications

In this study, we tested the hypothesis that a CB1 TMH3-4-5-6 aromatic microdomain, which includes F3.25(190), F3.36(201), W5.43(280), and W6.48(357), is centrally involved in CB1 receptor activation, with the F3.36(201)/W6.48(357) interaction key to the maintenance of the CB1-inactive state. We have shown previously that when F3.36(201), W5.43(280), and W6.48(357) are individually mutated to alanine, a significant reduction in ligand binding affinity is observed in the presence of WIN 55,212-2 and SR141716A but not CP55,940 and anandamide. In the work presented here, we report a detailed functional analysis of the F3.36(201)A, F3.25(190)A, W5.43(280)A, and W6.48(357)A mutant receptors …


Complex Multiplication Of Exactly Solvable Calabi-Yau Varieties, Monika Lynker, Rolf Schimmrigk, Steven Stewart Nov 2004

Complex Multiplication Of Exactly Solvable Calabi-Yau Varieties, Monika Lynker, Rolf Schimmrigk, Steven Stewart

Faculty and Research Publications

We propose a conceptual framework that leads to an abstract characterization for the exact solvability of Calabi–Yau varieties in terms of abelian varieties with complex multiplication. The abelian manifolds are derived from the cohomology of the Calabi–Yau manifold, and the conformal field theoretic quantities of the underlying string emerge from the number theoretic structure induced on the varieties by the complex multiplication symmetry. The geometric structure that provides a conceptual interpretation of the relation between geometry and conformal field theory is discrete, and turns out to be given by the torsion points on the abelian varieties.


High-Resolution, Wide-Field Imaging Of The Galactic Center Region At 330 Mhz, Michael E. Nord, T. Joseph W. Lazio, Namir E. Kassim, Scott D. Hyman, Ted W. La Rosa, Crystal L. Brogan, Nebojsa Duric Oct 2004

High-Resolution, Wide-Field Imaging Of The Galactic Center Region At 330 Mhz, Michael E. Nord, T. Joseph W. Lazio, Namir E. Kassim, Scott D. Hyman, Ted W. La Rosa, Crystal L. Brogan, Nebojsa Duric

Faculty and Research Publications

We present a wide-field, subarcminute-resolution VLA image of the Galactic center region at 330 MHz. With a resolution of ~7'' × 12'' and an rms noise of 1.6 mJy beam-1, this image represents a significant increase in resolution and sensitivity over the previously published VLA image at this frequency. The improved sensitivity has more than tripled the census of small-diameter sources in the region, has resulted in the detection of two new nonthermal filaments (NTFs), 18 NTF candidates, and 30 pulsar candidates, reveals previously known extended sources in greater detail, and has resulted in the first detection of …


Randy's Return: A Case Study In Food Safety Regulation, Matthew Laposata Oct 2004

Randy's Return: A Case Study In Food Safety Regulation, Matthew Laposata

Faculty and Research Publications

No abstract provided.


The Morphology Of Steve, Eugenie C. Scott, Nicholas J. Matzke, Glenn Branch, Steven Mccullagh Jul 2004

The Morphology Of Steve, Eugenie C. Scott, Nicholas J. Matzke, Glenn Branch, Steven Mccullagh

Faculty and Research Publications

This report is part of Project Steve. Project Steve is, among other things, the first scientific analysis of the sex, geographic location, and body size of scientists named Steve. We performed this research for the best of all reasons: we discovered that we had lots of data. No scientist can resist the opportunity to analyze data, regardless of where that data came from or why it was gathered.


New Nonthermal Filaments At The Galactic Center: Are They Tracing A Globally Ordered Magnetic Field?, Ted La Rosa, Michael E. Nord, Joseph W. Lazlo, Namir E. Kassim May 2004

New Nonthermal Filaments At The Galactic Center: Are They Tracing A Globally Ordered Magnetic Field?, Ted La Rosa, Michael E. Nord, Joseph W. Lazlo, Namir E. Kassim

Faculty and Research Publications

New high-resolution, wide-field 90 cm VLA observations of the Galactic center (GC) region by Nord and coworkers have revealed 20 nonthermal filament (NTF) candidates. We report 6 cm polarization observations of six of these. All of the candidates have the expected NTF morphology, and two show extended polarization, confirming their identification as NTFs. One of the new NTFs appears to be part of a system of NTFs located in the Sgr B region, 64 pc in projection north of Sgr A. These filaments cross the Galactic plane with an orientation similar to the filaments in the Galactic center radio arc. …


Itguru - A Powerful Network Simulation Environment For Teaching And Research, Victor A. Clincy May 2004

Itguru - A Powerful Network Simulation Environment For Teaching And Research, Victor A. Clincy

Faculty and Research Publications

ITGuru is a powerful simulation environment developed by OpNET Corporation. ITGuru is unique because of its ability to model the entire network, including its routers, switches, protocols, servers, and the individual applications they support. ITGuru improves network designers and instructors the ability to identify and solve problems throughout their network. ITGuru assesses application impact, automates diagnostic testing, expedites server capacity planning and consolidation, analyzes failure impact, and enables network growth planning


Move To Component Based Architectures: Introducing Microsoft's .Net Platform Into The College Classroom, Meg C. Murray Jan 2004

Move To Component Based Architectures: Introducing Microsoft's .Net Platform Into The College Classroom, Meg C. Murray

Faculty and Research Publications

A transformation has been occurring in the architectural model for computer-based application intense software systems. This new model, software-as-a-service, will have a profound impact on the design and development of software for many years to come and as such college level computing curriculums will need to incorporate the concepts and methodologies associated with this new architecture. The platform is built upon a view of interrelated, distributed peer-level software modules and components that work in tandem to achieve specified functional goals. From Microsoft's viewpoint, migration to the new platform requires a radical shift in the software development lifecycle. It is becoming …