Physical Sciences and Mathematics Commons^™

A Machine Learning Framework For Identifying Molecular Biomarkers From Transcriptomic Cancer Data, Md Abdullah Al Mamun

FIU Electronic Theses and Dissertations

Cancer is a complex molecular process due to abnormal changes in the genome, such as mutation and copy number variation, and epigenetic aberrations such as dysregulations of long non-coding RNA (lncRNA). These abnormal changes are reflected in transcriptome by turning oncogenes on and tumor suppressor genes off, which are considered cancer biomarkers.

However, transcriptomic data is high dimensional, and finding the best subset of genes (features) related to causing cancer is computationally challenging and expensive. Thus, developing a feature selection framework to discover molecular biomarkers for cancer is critical.

Traditional approaches for biomarker discovery calculate the fold change for each …

Volitional Control Of Lower-Limb Prosthesis With Vision-Assisted Environmental Awareness, S M Shafiul Hasan

FIU Electronic Theses and Dissertations

Early and reliable prediction of user’s intention to change locomotion mode or speed is critical for a smooth and natural lower limb prosthesis. Meanwhile, incorporation of explicit environmental feedback can facilitate context aware intelligent prosthesis which allows seamless operation in a variety of gait demands. This dissertation introduces environmental awareness through computer vision and enables early and accurate prediction of intention to start, stop or change speeds while walking. Electromyography (EMG), Electroencephalography (EEG), Inertial Measurement Unit (IMU), and Ground Reaction Force (GRF) sensors were used to predict intention to start, stop or increase walking speed. Furthermore, it was investigated whether …

Aptamer-Based Voltammetric Biosensing For The Detection Of Codeine And Fentanyl In Sweat And Saliva, Rosa Lashantez Cromartie

FIU Electronic Theses and Dissertations

Despite the many governmental and medicinal restrictions created to combat the opioid epidemic in the United States, opioid abuse and overdose rates continue to rise. The development of an aptamer-based voltammetric sensor and biosensor is described in this dissertation. The aim was to develop a low-cost, sensitive, and specific aptamer-based sensor for on-site, label-free determination of codeine and fentanyl in biological fluids. To do this, the surfaces of screen-printed carbon electrodes (SPCE) were modified with gold nanoparticles (AuNPs), followed by the addition of single-stranded DNA aptamers. These were covalently bound to the electrode surface. Operations of the sensors were collected …

Integrating Compound Flood Conditions Through 2d Hydraulic Modeling For Simulating Flood Risk Processes In Coastal Cities, Francisco Pena Guerra Mr.

FIU Electronic Theses and Dissertations

Low elevation coastal karst environments are highly vulnerable to flooding conditions due to climate change. Trends in rising global temperatures have increased the frequency and intensity of extreme precipitation, hydrometeorological phenomena and sea level rise, exacerbating the impact of pluvial, fluvial, coastal and groundwater flood hazards. Compound flooding events amplify flood hazards and pose a higher threat to residents and infrastructure in unison compared to independent phenomena. Recent advancements in coupling hydrologic and hydraulic modeling frameworks have improved our ability to account for the combined effects of extreme pluvial, fluvial, and coastal flood hazards. This innovation in the hydroinformatics field …

A Study Of Magnetism And Possible Mixed-State Superconductivity In Phosphorus-Doped Graphene, Julian E. Gil Pinzon

FIU Electronic Theses and Dissertations

Evidence of superconducting vortices, and consequently mixed-state superconductivity, has been observed in phosphorus-doped graphene at temperatures as high as 260 K. The evidence includes transport measurements in the form of resistance versus temperature curves, and magnetic measurements in the form of susceptibility and magnetic Nernst effect measurements. The drops in resistance, periodic steps in resistance, the appearance of Nernst peaks and hysteresis all point to phosphorus-doped graphene having a broad resistive region due to flux flow as well as a Berezinskii-Kosterlitz-Thouless (BKT) transition at lower temperatures.

The observation of irreversible behavior in phosphorus-doped graphene under the influence of a thermal …

Development Of A Real-Time Single-Lead Single-Beat Frequency-Independent Myocardial Infarction Detector, Harold Martin

FIU Electronic Theses and Dissertations

The central aim of this research is the development and deployment of a novel multilayer machine learning design with unique application for the diagnosis of myocardial infarctions (MIs) from individual heartbeats of single-lead electrocardiograms (EKGs) irrespective of their sampling frequencies over a given range. To the best of our knowledge, this design is the first to attempt inter-patient myocardial infarction detection from individual heartbeats of single-lead (lead II) electrocardiograms that achieves high accuracy and near real-time diagnosis. The processing time of 300 milliseconds to a diagnosis is just at the time range in between extremely fast heartbeats of around 300 …

Evaluation Of Parametric And Nonparametric Statistical Models In Wrong-Way Driving Crash Severity Prediction, Sajidur Rahman Nafis

FIU Electronic Theses and Dissertations

Wrong-way driving (WWD) crashes result in more fatalities per crash, involve more vehicles, and cause extended road closures compared to other types of crashes. Although crashes involving wrong-way drivers are relatively few, they often lead to fatalities and serious injuries. Researchers have been using parametric statistical models to identify factors that affect WWD crash severity. However, these parametric models are generally based on several assumptions, and the results could generate numerous errors and become questionable when these assumptions are violated. On the other hand, nonparametric methods such as data mining or machine learning techniques do not use a predetermined functional …

Digital And Mixed Domain Hardware Reduction Algorithms And Implementations For Massive Mimo, Najath A. Mohomed

FIU Electronic Theses and Dissertations

Emerging 5G and 6G based wireless communications systems largely rely on multiple-input-multiple-output (MIMO) systems to reduce inherently extensive path losses, facilitate high data rates, and high spatial diversity. Massive MIMO systems used in mmWave and sub-THz applications consists of hundreds perhaps thousands of antenna elements at base stations. Digital beamforming techniques provide the highest flexibility and better degrees of freedom for phased antenna arrays as compared to its analog and hybrid alternatives but has the highest hardware complexity.

Conventional digital beamformers at the receiver require a dedicated analog to digital converter (ADC) for every antenna element, leading to ADCs for …

Defense By Deception Against Stealthy Attacks In Power Grids, Md Hasan Shahriar

FIU Electronic Theses and Dissertations

Cyber-physical Systems (CPSs) and the Internet of Things (IoT) are converging towards a hybrid platform that is becoming ubiquitous in all modern infrastructures. The integration of the complex and heterogeneous systems creates enormous space for the adversaries to get into the network and inject cleverly crafted false data into measurements, misleading the control center to make erroneous decisions. Besides, the attacker can make a critical part of the system unavailable by compromising the sensor data availability. To obfuscate and mislead the attackers, we propose DDAF, a deceptive data acquisition framework for CPSs' hierarchical communication network. Each switch in the hierarchical …

Organic-Inorganic Halide Perovskite Nanocrystals And Solar Cells, Rui Guo

FIU Electronic Theses and Dissertations

A great challenge facing humanity in the 21^st century is finding inexhaustible and inexpensive energy sources to power the planet. Renewable energies are the best solutions because of their abundance, diversity, and pollution-free emission. Solar energy is the cleanest and most abundant renewable energy source available. In the continuing quest for efficient and low-cost solar cells, perovskite solar cells (PSCs) have emerged as a potential replacement for silicon solar cells. Since 2009, the record efficiencies of PSCs have been skyrocketing from 3.8 % to 25.2 % and are now approaching the theoretical limit. Along with the three-dimensional perovskites used …

Surface Enhanced Raman Spectroscopy (Sers) As A Nanoscale Adsorption Phenomenon: Development Of Tailored Nanomaterials For Applications In Drug Detection, Chiara Deriu

FIU Electronic Theses and Dissertations

Surface Enhanced Raman Spectroscopy (SERS) is an analytical technique in which nanostructured substrates amplify the inherently weak Raman signal of an adsorbed species by several orders of magnitude, enabling the detection of trace compounds, up to the single molecule level. While this may be an exceptional tool for any analytical scientist, SERS is at present relegated to the role of academic sensation, and is underutilized in everyday analytical practice. The SERS community is increasingly attributing this setback to a poor understanding of nanoscale surfaces and their chemical environment; since molecular adsorption at the nanostructured surface enables SERS detection, uncertainty about …

A Comprehensive Security Framework For Securing Sensors In Smart Devices And Applications, Amit Kumar Sikder

FIU Electronic Theses and Dissertations

This doctoral dissertation introduces novel security frameworks to detect sensor-based threats on smart devices and applications in smart settings such as smart home, smart office, etc. First, we present a formal taxonomy and in-depth impact analysis of existing sensor-based threats to smart devices and applications based on attack characteristics, targeted components, and capabilities. Then, we design a novel context-aware intrusion detection system, 6thSense, to detect sensor-based threats in standalone smart devices (e.g., smartphone, smart watch, etc.). 6thSense considers user activity-sensor co-dependence in standalone smart devices to learn the ongoing user activity contexts and builds a context-aware model to distinguish malicious …

3d Architectural Analysis Of Neurons, Astrocytes, Vasculature & Nuclei In The Motor And Somatosensory Murine Cortical Columns, Jared Leichner

FIU Electronic Theses and Dissertations

Characterization of the complex cortical structure of the brain at a cellular level is a fundamental goal of neuroscience which can provide a better understanding of both normal function as well as disease state progression. Many challenges exist however when carrying out this form of analysis. Immunofluorescent staining is a key technique for revealing 3-dimensional structure, but subsequent fluorescence microscopy is limited by the quantity of simultaneous targets that can be labeled and intrinsic lateral and isotropic axial point-spread function (PSF) blurring during the imaging process in a spectral and depth-dependent manner. Even after successful staining, imaging and optical deconvolution, …

Mitigating Stealthy Link Flooding Ddos Attacks Using Sdn-Based Moving Target Defense, Abdullah Aydeger

FIU Electronic Theses and Dissertations

With the increasing diversity and complication of Distributed Denial-of-Service (DDoS) attacks, it has become extremely challenging to design a fully protected network. For instance, recently, a new type of attack called Stealthy Link Flooding Attack (SLFA) has been shown to cause critical network disconnection problems, where the attacker targets the communication links in the surrounding area of a server. The existing defense mechanisms for this type of attack are based on the detection of some unusual traffic patterns; however, this might be too late as some severe damage might already be done. These mechanisms also do not consider countermeasures during …

Development Of Gaussian Learning Algorithms For Early Detection Of Alzheimer's Disease, Chen Fang

FIU Electronic Theses and Dissertations

Alzheimer’s disease (AD) is the most common form of dementia affecting 10% of the population over the age of 65 and the growing costs in managing AD are estimated to be $259 billion, according to data reported in the 2017 by the Alzheimer's Association. Moreover, with cognitive decline, daily life of the affected persons and their families are severely impacted. Taking advantage of the diagnosis of AD and its prodromal stage of mild cognitive impairment (MCI), an early treatment may help patients preserve the quality of life and slow the progression of the disease, even though the underlying disease cannot …

Reputation-Aware Trajectory-Based Data Mining In The Internet Of Things (Iot), Samia Tasnim

FIU Electronic Theses and Dissertations

Internet of Things (IoT) is a critically important technology for the acquisition of spatiotemporally dense data in diverse applications, ranging from environmental monitoring to surveillance systems. Such data helps us improve our transportation systems, monitor our air quality and the spread of diseases, respond to natural disasters, and a bevy of other applications. However, IoT sensor data is error-prone due to a number of reasons: sensors may be deployed in hazardous environments, may deplete their energy resources, have mechanical faults, or maybe become the targets of malicious attacks by adversaries. While previous research has attempted to improve the quality of …

Trajectory Privacy Preservation And Lightweight Blockchain Techniques For Mobility-Centric Iot, Abdur Bin Shahid

FIU Electronic Theses and Dissertations

Various research efforts have been undertaken to solve the problem of trajectory privacy preservation in the Internet of Things (IoT) of resource-constrained mobile devices. Most attempts at resolving the problem have focused on the centralized model of IoT, which either impose high delay or fail against a privacy-invading attack with long-term trajectory observation. These proposed solutions also fail to guarantee location privacy for trajectories with both geo-tagged and non-geo-tagged data, since they are designed for geo-tagged trajectories only. While a few blockchain-based techniques have been suggested for preserving trajectory privacy in decentralized model of IoT, they require large storage capacity …

A Privacy Framework For Decentralized Applications Using Blockchains And Zero Knowledge Proofs, David Gabay

FIU Electronic Theses and Dissertations

With the increasing interest in connected vehicles along with electrification opportunities, there is an ongoing effort to automate the charging process of electric vehicles (EVs) through their capabilities to communicate with the infrastructure and each other. However, charging EVs takes time and thus in-advance scheduling is needed. As this process is done frequently due to limited mileage of EVs, it may expose the locations and charging pattern of the EV to the service providers, raising privacy concerns for their users. Nevertheless, the EV still needs to be authenticated to charging providers, which means some information will need to be provided …

Centralized And Distributed Detection Of Compromised Smart Grid Devices Using Machine Learning And Convolution Techniques, Cengiz Kaygusuz

FIU Electronic Theses and Dissertations

The smart grid concept has further transformed the traditional power grid into a massive cyber-physical system that depends on advanced two-way communication infrastructure. While the introduction of cyber components has improved the grid, it has also broadened the attack surface. In particular, the threat stemming from compromised devices pose a significant danger: An attacker can control the devices to change the behavior of the grid and can impact the measurements or damage the grid equipment. In this thesis, to detect such malicious smart grid devices, we propose a novel machine learning and convolution-based framework, named PowerWatch, that is able to …

Cloud Workload Allocation Approaches For Quality Of Service Guarantee And Cybersecurity Risk Management, Soamar Homsi

FIU Electronic Theses and Dissertations

It has become a dominant trend in industry to adopt cloud computing --thanks to its unique advantages in flexibility, scalability, elasticity and cost efficiency -- for providing online cloud services over the Internet using large-scale data centers. In the meantime, the relentless increase in demand for affordable and high-quality cloud-based services, for individuals and businesses, has led to tremendously high power consumption and operating expense and thus has posed pressing challenges on cloud service providers in finding efficient resource allocation policies.

Allowing several services or Virtual Machines (VMs) to commonly share the cloud's infrastructure enables cloud providers to optimize resource …

Context-Aware Personalized Point-Of-Interest Recommendation System, Ramesh Raj Baral

FIU Electronic Theses and Dissertations

The increasing volume of information has created overwhelming challenges to extract the relevant items manually. Fortunately, the online systems, such as e-commerce (e.g., Amazon), location-based social networks (LBSNs) (e.g., Facebook) among many others have the ability to track end users' browsing and consumption experiences. Such explicit experiences (e.g., ratings) and many implicit contexts (e.g., social, spatial, temporal, and categorical) are useful in preference elicitation and recommendation. As an emerging branch of information filtering, the recommendation systems are already popular in many domains, such as movies (e.g., YouTube), music (e.g., Pandora), and Point-of-Interest (POI) (e.g., Yelp).

The POI domain has many …

Multi-Robot Coordination And Scheduling For Deactivation & Decommissioning, Sebastian A. Zanlongo

FIU Electronic Theses and Dissertations

Large quantities of high-level radioactive waste were generated during WWII. This waste is being stored in facilities such as double-shell tanks in Washington, and the Waste Isolation Pilot Plant in New Mexico. Due to the dangerous nature of radioactive waste, these facilities must undergo periodic inspections to ensure that leaks are detected quickly. In this work, we provide a set of methodologies to aid in the monitoring and inspection of these hazardous facilities. This allows inspection of dangerous regions without a human operator, and for the inspection of locations where a person would not be physically able to enter.

First, …

A Mathematical Framework On Machine Learning: Theory And Application, Bin Shi

FIU Electronic Theses and Dissertations

The dissertation addresses the research topics of machine learning outlined below. We developed the theory about traditional first-order algorithms from convex opti- mization and provide new insights in nonconvex objective functions from machine learning. Based on the theory analysis, we designed and developed new algorithms to overcome the difficulty of nonconvex objective and to accelerate the speed to obtain the desired result. In this thesis, we answer the two questions: (1) How to design a step size for gradient descent with random initialization? (2) Can we accelerate the current convex optimization algorithms and improve them into nonconvex objective? For application, …

Game-Theoretic And Machine-Learning Techniques For Cyber-Physical Security And Resilience In Smart Grid, Longfei Wei

FIU Electronic Theses and Dissertations

The smart grid is the next-generation electrical infrastructure utilizing Information and Communication Technologies (ICTs), whose architecture is evolving from a utility-centric structure to a distributed Cyber-Physical System (CPS) integrated with a large-scale of renewable energy resources. However, meeting reliability objectives in the smart grid becomes increasingly challenging owing to the high penetration of renewable resources and changing weather conditions. Moreover, the cyber-physical attack targeted at the smart grid has become a major threat because millions of electronic devices interconnected via communication networks expose unprecedented vulnerabilities, thereby increasing the potential attack surface. This dissertation is aimed at developing novel game-theoretic and …

Design Of Low Impact Development And Green Infrastructure At Flood Prone Areas In The City Of Miami Beach, Florida, Usa, Noura Alsarawi

FIU Electronic Theses and Dissertations

This thesis investigates the effectiveness of Low Impact Development Infrastructure (LIDI) and Green Infrastructure (GI) in reducing flooding resulting from heavy rainfall events and sea-level rise, and in improving stormwater quality in the City of Miami Beach (CMB). InfoSWMM was used to simulate the 5, 10, and 100-year, 24-hour storm events, total suspended solids (TSS), biochemical oxygen demand (BOD), and chemical oxygen demand (COD) loadings, and in evaluating the potential of selected LIDI and GI solutions in North Shore neighborhood.

Post-development results revealed a decrease of 48%, 46%, and 39% in runoff, a decrease of 57%, 60%, and 62% in …

A Simplified Secure Programming Platform For Internet Of Things Devices, Halim Burak Yesilyurt

FIU Electronic Theses and Dissertations

The emerging Internet of Things (IoT) revolution has introduced many useful applications that are utilized in our daily lives. Users can program these devices in order to develop their own IoT applications; however, the platforms and languages that are used during development are abounding, complicated, and time-consuming. The software solution provided in this thesis, PROVIZ+, is a secure sensor application development software suite that helps users create sophisticated and secure IoT applications with little software and hardware experience. Moreover, a simple and efficient domain-specific programming language, namely Panther language, was designed for IoT application development to unify existing programming languages. …

User-Centric Privacy Preservation In Mobile And Location-Aware Applications, Mingming Guo

FIU Electronic Theses and Dissertations

The mobile and wireless community has brought a significant growth of location-aware devices including smart phones, connected vehicles and IoT devices. The combination of location-aware sensing, data processing and wireless communication in these devices leads to the rapid development of mobile and location-aware applications. Meanwhile, user privacy is becoming an indispensable concern. These mobile and location-aware applications, which collect data from mobile sensors carried by users or vehicles, return valuable data collection services (e.g., health condition monitoring, traffic monitoring, and natural disaster forecasting) in real time. The sequential spatial-temporal data queries sent by users provide their location trajectory information. The …

Rethinking The I/O Stack For Persistent Memory, Mohammad Ataur Rahman Chowdhury

FIU Electronic Theses and Dissertations

Modern operating systems have been designed around the hypotheses that (a) memory is both byte-addressable and volatile and (b) storage is block addressable and persistent. The arrival of new Persistent Memory (PM) technologies, has made these assumptions obsolete. Despite much of the recent work in this space, the need for consistently sharing PM data across multiple applications remains an urgent, unsolved problem. Furthermore, the availability of simple yet powerful operating system support remains elusive.

In this dissertation, we propose and build The Region System – a high-performance operating system stack for PM that implements usable consistency and persistence for application …

Hybrid Electrochemical Capacitors: Materials, Optimization, And Miniaturization, Richa Agrawal

FIU Electronic Theses and Dissertations

With the ever-advancing technology, there is an incessant need for reliable electrochemical energy storage (EES) components that can provide desired energy and power. At the forefront of EES systems are electrochemical capacitors (ECs), also known as supercapacitors that typically have higher power and superior cycle longevity but lower energy densities than their battery counterparts. One of the routes to achieve higher energy density for ECs is using the hybrid EC configuration, which typically utilizes a redox electrode coupled with a counter double-layer type electrode.

In this dissertation, both scale-up (coin-cell type) as well as scale-down (on-chip miniaturized) hybrid ECs were …

Resilient And Real-Time Control For The Optimum Management Of Hybrid Energy Storage Systems With Distributed Dynamic Demands, Christopher R. Lashway

FIU Electronic Theses and Dissertations

A continuous increase in demands from the utility grid and traction applications have steered public attention toward the integration of energy storage (ES) and hybrid ES (HESS) solutions. Modern technologies are no longer limited to batteries, but can include supercapacitors (SC) and flywheel electromechanical ES well. However, insufficient control and algorithms to monitor these devices can result in a wide range of operational issues. A modern day control platform must have a deep understanding of the source. In this dissertation, specialized modular Energy Storage Management Controllers (ESMC) were developed to interface with a variety of ES devices. The EMSC provides …