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The Effects Of Molecular Chaperones On Tau Fibril Assembly, Ahmed Omran
The Effects Of Molecular Chaperones On Tau Fibril Assembly, Ahmed Omran
Electronic Theses and Dissertations
The accumulation of microtubule-associated protein tau into fibrillar aggregates is the hallmark of Alzheimer’s disease and other neurodegenerative disorders, collectively referred to as tauopathies. Fibrils can propagate from one cell to the next and spread throughout the brain. However, a study shows that only small aggregates can be taken up by cultured neuronal cells. The mechanisms that lead to the breakage of fibrils into smaller fragments remain unknown. In yeast, the AAA+ chaperone HSP104 processes the reactivation of protein aggregates and is responsible for fragmentation of fibrils. This study focused on investigating the effects of molecular chaperones on tau fibrils …
Statistical Power Analysis Of Dissertations Completed By Students Majoring In Educational Leadership At Tennessee Universities, Heping Deng
Electronic Theses and Dissertations
The purpose of this study was to estimate the level of statistical power demonstrated in recent dissertations in the field of educational leadership. Power tables provided in Cohen's (1988) Statistical Power Analysis for the Behavioral Sciences were used to determine the power of the statistical tests conducted in dissertations selected from five universities in Tennessee. The meta-analytic approach was used to summarize and synthesize the findings. The population of this study consisted of all dissertations successfully defended by doctoral students majoring in educational leadership/administration at East Tennessee State University, the University of Tennessee at Knoxville, Tennessee State University, the University …
A Characterization Of Extractable, Hydroxylated Fatty Acid Bearing Components In Legionella Pneumophila, Jonathan R. Lane
A Characterization Of Extractable, Hydroxylated Fatty Acid Bearing Components In Legionella Pneumophila, Jonathan R. Lane
Electronic Theses and Dissertations
Extraction of the lipids of Legionella pneumophila yields phases unlike those produced from other Gram-negative bacteria. A viscous interface forms between the aqueous (wash) and organic phases. More than half of the hydroxylated fatty acids were found distributed between the aqueous phase and the interfacial material, fractions in which such constituents have not been reported in other Gram-negative species. It was further observed that after the material from the aqueous/interfacial phase was dissolved in methanol or chloroform/methanol (2:1 (V/V)), the addition of acetone would create a white, flocculent precipitate. Analyses showed that the supernatant contained fatty acids that were nonhydroxylated …