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Full-Text Articles in Physical Sciences and Mathematics
Development Of A Biosensor For Investigating Membrane Curvature Sorting, Joshua C. Black
Development Of A Biosensor For Investigating Membrane Curvature Sorting, Joshua C. Black
Electronic Theses and Dissertations
The physical structure of cellular membranes plays a critical role in lipid and protein sorting. A novel biosensor was developed to probe the influence of curvature on sorting. This biosensor mimics large, two-dimensional membranes in dynamic equilibrium, achieves high spatial resolution between curvature and molecules of interest, and has high sensitivity, enough for single particle detection. The biosensor consists of continuous supported lipid bilayer formed over nanoparticles (40 to 200 nm diameter) deposited on a glass substrate. The nanoparticles determine the extent of curvature. This biosensor is the first to observe large-scale 2-dimensional diffusion of biomolecules on a supported lipid …
Theoretical Studies Of Nanostructure Formation And Transport On Surfaces, Maral Aminpour
Theoretical Studies Of Nanostructure Formation And Transport On Surfaces, Maral Aminpour
Electronic Theses and Dissertations
This dissertation undertakes theoretical and computational research to characterize and understand in detail atomic configurations and electronic structural properties of surfaces and interfaces at the nano-scale, with particular emphasis on identifying the factors that control atomic-scale diffusion and transport properties. The overarching goal is to outline, with examples, a predictive modeling procedure of stable structures of novel materials that, on the one hand, facilitates a better understanding of experimental results, and on the other hand, provide guidelines for future experimental work. The results of this dissertation are useful in future miniaturization of electronic devices, predicting and engineering functional novel nanostructures. …