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Articles 1 - 13 of 13
Full-Text Articles in Physical Sciences and Mathematics
Development Of Quantitative Bioanalytical Methods For The Pharmacological Studies Of Anti-Cancer Drugs, Ye Feng
ETD Archive
In the anticancer drug discovery and therapy development, it is essential to understand the pharmacological properties of the drugs. Today, pharmaceutical analysis is employed throughout the whole drug discovery and development process. Pharmacokinetic-pharmacodynamic relationships are playing an increasingly important role in decisions on the rational development and use of new drugs and they can provide a detailed knowledge of the mechanism of the drug and a better understanding of the molecular targets on which they act. Due to the significance of pharmacological analysis, sensitive analytical methods are critically needed for pharmacological studies. Therefore, our long-term goal is to provide guidelines …
Optimization Of Gradient Chromatofocusing For The Protein Separation And Lc-Ms/Ms Determination Of Ngp1-01 In Mouse Serum, Brain, And Retina, Harini Jogiraju
Optimization Of Gradient Chromatofocusing For The Protein Separation And Lc-Ms/Ms Determination Of Ngp1-01 In Mouse Serum, Brain, And Retina, Harini Jogiraju
ETD Archive
No abstract provided.
A Multi-Taxonomic Approach To Assess The Impact Of Overabundant White-Tailed Deer (Odocoileus Virginianus) In Forest Ecosystems Across Northeast Ohio, Sara A. Laux
ETD Archive
Browsing by white-tailed deer has alters plant species diversity of the forest understory across much of North America. A reduced understory may lead to the simplification of the forest-floor microhabitat, causing broad scale shifts in the community composition and abundance of litter-dwelling arthropods and small mammals. The objectives of this study were to 1) document changes in the forest-floor microhabitat as a result of over-browsing by deer and 2) determine if differential browsing pressures indirectly affect faunal biodiversity (litter-dwelling arthropods and small mammals) of forest ecosystems. I predicted that browsing within the understory will reduce structural complexity of the forest-floor …
Design, Synthesis And Characterization Of Chain-End Functionalized Glyco-Polymer For Efficient Proteomic Analysis, Satya Nandana Narla
Design, Synthesis And Characterization Of Chain-End Functionalized Glyco-Polymer For Efficient Proteomic Analysis, Satya Nandana Narla
ETD Archive
No abstract provided.
Gradient Chromatofocusing And Reversed Phase Hplc In Protein Analysis And Lc-Ms/Ms Determination Of Thiazolidinedione Nl-1 In Mouse Serum And Brain, Kiran K. Pedada
Gradient Chromatofocusing And Reversed Phase Hplc In Protein Analysis And Lc-Ms/Ms Determination Of Thiazolidinedione Nl-1 In Mouse Serum And Brain, Kiran K. Pedada
ETD Archive
No abstract provided.
Development Of Lc-Ms/Ms Methods For Quantitative Analysis Of Plant-Derived Anticancer Agent And Synthetic Estrogen In Complex Matrices, Simuli Lindah Wabuyele
Development Of Lc-Ms/Ms Methods For Quantitative Analysis Of Plant-Derived Anticancer Agent And Synthetic Estrogen In Complex Matrices, Simuli Lindah Wabuyele
ETD Archive
No abstract provided.
Singing Behavior And Geographic Variation In The Songs Of The Veery (Catharus Fuscescens) Across The Appalachian Mountains, Courtney L. Brennan
Singing Behavior And Geographic Variation In The Songs Of The Veery (Catharus Fuscescens) Across The Appalachian Mountains, Courtney L. Brennan
ETD Archive
The Veery (Catharus fuscescens) is a common Neotropical migrant thrush whose breeding distribution spans the Northern United States and southern Canada and continues south through the high elevations of the Appalachian Mountains. Despite its wide distribution, many aspects of Veery biology are largely unknown, including a clear characterization of song and knowledge of geographic song variation. I describe the song structure, repertoire size, and patterns of song delivery in the songs of the Veery and describe geographic song variation across four regions along the Appalachian Mountains. Visual analysis of song spectrogram images of territorial males revealed that Veeries' repertoire ranges …
Influence Of Earthworms On Plant And Soil Invertebrate Communities Of The Cleveland Metroparks, Anton F. Schermaier
Influence Of Earthworms On Plant And Soil Invertebrate Communities Of The Cleveland Metroparks, Anton F. Schermaier
ETD Archive
No native earthworms exist in the Great Lakes region of Ohio. All earthworms found in previously glaciated areas of the United States either migrated from unglaciated areas or were introduced as a result of human activities such as agriculture and sport fishing. Non-native earthworms may facilitate dramatic changes in structure and function of plant and invertebrate communities of forest ecosystems. This study examined how the presence of non-native earthworms within the Cleveland Metroparks may correspond with plant and soil invertebrate communities. Special attention was given to the Asian earthworm, Amynthas spp., a recent arrival to northeastern Ohio and a particularly …
The Effects Of Urban Land Use On Wasps: (Hymenoptera: Apocrita), Klaire Elise Freeman
The Effects Of Urban Land Use On Wasps: (Hymenoptera: Apocrita), Klaire Elise Freeman
ETD Archive
For the first time in human history, more than half of the human population lives in urban areas (Pickett et al 2011). It is essential that research occurs in urban ecosystems understanding both the biological and social aspects of urban ecosystems is needed for the sustainable management of urban ecosystems (Angold et al. 2006, Fetridge et al. 2008, Loram et al. 2008, Matteson et al. 2008, McIntyre 2000, Picket et al 2011, Pickett et al 2001, Sumoski et al. 2009) This study examines the role of insects, specifically wasps, in urban gardens and vacant lots in Cleveland, Ohio. This study …
Saline Adaptation Of The Microalga Scenedesmus Dimorphus: From Fresh Water To Brackish Water, Bethany Marie Gigante
Saline Adaptation Of The Microalga Scenedesmus Dimorphus: From Fresh Water To Brackish Water, Bethany Marie Gigante
ETD Archive
The fresh water microalga Scenedesmus dimorphus is of interest in the microalgae to biofuel field. With a 26 dry weight as lipid content and a potential doubling time of 60-70 hours, it is a viable candidate for biofuel production. Recent studies have focused on optimizing the growth rate and lipid content of S. dimorphus by finding ideal light, carbon-dioxide flow rates, nutrient composition of media, pH, temperature, and implementation of various stresses in the growth environment. Adaptation of S. dimorphus to a saline environment would make it a viable biofuel stock world-wide. This saline adaptation experiment was conducted in two …
Assessment Of Freshwater Mussel Communities Of Small Stream Mouths Along Lake Erie, Trevor J. Prescott
Assessment Of Freshwater Mussel Communities Of Small Stream Mouths Along Lake Erie, Trevor J. Prescott
ETD Archive
Invasion of lakes and rivers by dreissenid mussels pushed out native species, particularly freshwater mussels in the Unionidae, across the northern hemisphere, and perhaps most infamously, within the Laurentian Great Lakes. However, several coastal areas along the shallowest of these lakes, Lake Erie, may be refugia for native species, but the conditions under which native species persist are unknown. I surveyed river mouths of small streams along the Lake Erie coastline and compared species abundance to land use assessed by remote sensing techniques and to standard measures of water chemistry. Sampling focused on stream zones influenced by lake-water levels for …
Nos Oxygenase-Mediated Nitroalkane Catalytic Reduction: Impact On Nos Reaction, Praneeth Ivan Joel Fnu
Nos Oxygenase-Mediated Nitroalkane Catalytic Reduction: Impact On Nos Reaction, Praneeth Ivan Joel Fnu
ETD Archive
Organic nitroalkanes are used in many industries and for a variety of purposes. Their use is expanding and is steadily claiming new territories in our immediate environment. Some nitroalkanes, when they enter the human body, can be harmful as such or can be activated to generate reactive intermediates with known detrimental effects. P450 enzymes are known for metabolizing a variety of drugs and substances including organic nitroalkanes. Nitric oxide synthases (NOS) exhibit some similarities to P450 metalloenzymes and their potential interaction with nitroalkanes as xenobiotics is not well known. The present study investigates the effect of nitroalkanes on the catalytic …
Automated Spectral Identification Of Materials Using Spectral Identity Mapping, Robert William Cannon
Automated Spectral Identification Of Materials Using Spectral Identity Mapping, Robert William Cannon
ETD Archive
With increased use of Raman spectroscopic instrumentation for material analysis there has also been an increase in the amount of acquired Raman spectral data. Because of this, there is a clear need to develop and implement advanced spectral analysis techniques. This is especially true in cases where limited reference data may be available and large data sets need to be interpreted. Raman spectral analysis and standardization techniques, along with a foundation for a comprehensive repository of Raman spectral data, will be described in this thesis. The main focus will be automated analysis and standardization of Raman spectral data using spectral …