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Articles 1 - 12 of 12
Full-Text Articles in Physical Sciences and Mathematics
Design, Synthesis And Characterization Of Oriented Glyco-Affinity Macroligands For Glyco-Capturing, Glycomics And Glycoproteomics Applications, Srinivas Chalagalla
Design, Synthesis And Characterization Of Oriented Glyco-Affinity Macroligands For Glyco-Capturing, Glycomics And Glycoproteomics Applications, Srinivas Chalagalla
ETD Archive
Cell surface carbohydrates existing as parts of glycoproteins, glycolipids, and other conjugates present the first information about cell to the outside world and are intimately involved in various biological events such as intercellular communication, and molecular and cellular targeting. However, mechanisms of most processes at the molecular level are still unclear. Therefore, it is very important to develop carbohydrate-specific binding molecules for rapid, efficient, sensitive purification and accurate analysis of complex carbohydrate structures as well as their functions. Furthermore, carbohydrate-specific binding molecules can be expected to be used in medical diagnostic applications for carbohydrate biomarkers. In this thesis study, oriented …
Interactions Among Top-Down Regulators In A Temperate Forest Floor Ecosystem;Effects On Macrofauna, Mesofauna, Microbes And Litter Decay, Cari-Ann M. Hickerson
Interactions Among Top-Down Regulators In A Temperate Forest Floor Ecosystem;Effects On Macrofauna, Mesofauna, Microbes And Litter Decay, Cari-Ann M. Hickerson
ETD Archive
High species diversity and complexity of forest-floor food webs present a challenge for understanding the role of species interactions (e.g. competition and predation) as regulatory mechanisms for ecosystem processes such as decomposition and nutrient cycling. In particular, we understand very little about the roles of forest-floor predators in regulating diversity and abundance of lower trophic levels and ecosystem processes. However, ecological theory and several studies suggest that interactions among intraguild predators (IGP) may be important controls of diversity and abundance of organisms and detritus in lower trophic levels within food webs. A key prediction is that interactions among predators weaken …
Effects Of Forest Edges, Exotic Ants And Nonnative Plants On Local Ant (Hymenoptera: Formicidae) Diversity In Urban Forest Fragments Of Northeastern Ohio, Kaloyan Ivanov
ETD Archive
Urbanization has resulted in massive transformation of natural habitats with profound effects on biodiversity. Addressing the problems associated with anthropogenic deterioration of the environment requires solid understanding of the factors driving these changes. Habitat patch size, edge effects, and the presence of invasive species are among the key features of the urban landscape affecting local communities. My study focused on the effects of habitat edges, the exotic ant Nylanderia flavipes, and the invasive herb garlic mustard on local ant diversity in deciduous forest fragments of northeastern Ohio. In addition, I explored the value of common ant collecting techniques for estimating …
Dna Mutation/Methylation Screening Method For Colon Cancer Screening, Wei Meng
Dna Mutation/Methylation Screening Method For Colon Cancer Screening, Wei Meng
ETD Archive
Cancer is a result of unregulated cell growth. For all types of cancer currently studied, the transition from a healthy cell to a malignant tumor cell is a step-by-step process which requires mutation in at least several oncogenes and tumor suppressor genes together. Another cancer early event is DNA methylation. Cancer-related DNA methylation focuses on promoter hypermethylation of the certain genes. The DNA mutation and methylation profile can serve as biomarkers for diagnosing early stage of cancer. Colorectal cancer is the third most common cancer type in the United States and has been well studied. The essential mechanism of cancer …
Molecular Basis Of The Role Of Kindlin 2 In Cell Adhesion, Hettiarachchige Dhanuja Deepamalee Perera
Molecular Basis Of The Role Of Kindlin 2 In Cell Adhesion, Hettiarachchige Dhanuja Deepamalee Perera
ETD Archive
Kindlins are a novel family of cytoskeleton proteins that plays an important role in the activation of heterodimeric integrin transmembrane receptors. These receptors play a vital role in cell adhesion, cell migration and other cellular processes. The Kindlin protein family consists of three homologous proteins, Kindlin 1, 2 and 3 with differential tissue distribution and varying expression levels in human. Mutations of Kindlin 1 protein are clinically linked to Kindler Syndrome. Kindlin 2 knockdown studies have shown embryonic lethality in mouse, but no diseases have been clinically testified. Kindlin 3 mutations are associated with bleeding disorders, e.g. LADIII. Talin is …
An Assessment Of The Evolutionary Stability Of Distyly In Hedyotis Caerulea (Rubiaceae), Dennis Archie Sampson
An Assessment Of The Evolutionary Stability Of Distyly In Hedyotis Caerulea (Rubiaceae), Dennis Archie Sampson
ETD Archive
Distylous species of flowers possess two distinct floral morphs that are generally found in equal numbers in naturally occurring populations. The flower form that has a relatively long style is called a "pin" the form with a short style is a "thrum." Within the distylous mating system, selfing and intramorph mating are prevented due to the spatial separation of stigmas and anthers and by a self-incompatibility system that is inherited along with the dimorphic floral structure and ancillary polymorphisms. However, a breakdown of distyly has been documented in several families, either through the development of completely separate sexes (dioecy), or, …
Human Prostate Cancer Cell Apoptosis Induced By Interferon-Y And Double-Stranded Rna And Studies On The Biological Roles Of Transmembrane And Coiled-Coil Domains 1, Haiyan Tan
ETD Archive
No abstract provided.
Exploration Of Dynamic Web Page Partitioning For Increased Web Page Delivery Performance, Brian Michael Krupp
Exploration Of Dynamic Web Page Partitioning For Increased Web Page Delivery Performance, Brian Michael Krupp
ETD Archive
The increasing use of the Internet and demand for real-time information has increased the amount of dynamic content generated residing in more complex distributed environments. The performance of delivering these web pages has been improved through more traditional techniques such as caching and newer techniques such as pre-fetching. In this research, we explore the dynamic partitioning of web page content using concurrent AJAX requests to improve web page delivery performance for resource intensive synchronous web content. The focus is more on enterprise web applications that exist in an environment such that a page's data and processing is not local to …
Assessment Of Habitat Use By Eastern Coyote (Canis Latrans) Along An Urban-Parkland Gradient, Beth A. Judy
Assessment Of Habitat Use By Eastern Coyote (Canis Latrans) Along An Urban-Parkland Gradient, Beth A. Judy
ETD Archive
This study used coyote howl surveys combined with GIS to locate local coyote (Canis latrans) populations, determine the habitats where coyotes occur and estimate coyote group sizes in Bedford, North Chagrin and West Creek Reservations within the Cleveland Metroparks, Ohio. The CMP were established in 1917 and are the oldest park districts in the state of Ohio. There are 8,500 hectares (21,000 acres) of land in 16 reservations and in 2008 approximately 43,000,000 people visited the Cleveland Metroparks. Bedford, North Chagrin and West Creek Reservations have a mixture of park, forest, woodlots, residential neighborhoods, industrial areas, commercial property, open water, …
Mapping Riparian Vegetation In The Lower Colorado River Using Low Resolution Satellite Imagery, Kelly J. Amundsen
Mapping Riparian Vegetation In The Lower Colorado River Using Low Resolution Satellite Imagery, Kelly J. Amundsen
ETD Archive
In the Western United States, monitoring water usage is a complex task carried out by the U.S. Bureau of Reclamation (USBR). It may be argued that USBR's greatest challenge is equitably distributing the waters of the Colorado River, particularly the Lower Colorado River, where water rights have been established and contested several times. To help meet the demands of water management in the Lower Colorado River Basin, USBR estimates the amount of water lost from the basin each year via evapo-transpiration by riparian vegetation in the Lower Colorado River riparian zone. Key components of those estimates include maps of the …
Study Of Drug Delivery Behavior Through Biomembranes Using Thermal And Bioanalytical Techniques, Hareesha Reddy Venumuddala
Study Of Drug Delivery Behavior Through Biomembranes Using Thermal And Bioanalytical Techniques, Hareesha Reddy Venumuddala
ETD Archive
This Master of Science thesis encompasses two projects in chemical pharmaceuticals. The first is a study of excipients and the added new information collected beyond Thermal Gravimetric Analysis and Differential Scanning Calorimetry from Dielectric Analysis. These new properties enhance our global knowledge of excipients by thermal analytical methods. Excipients, the inactive ingredients in formulated drugs, aid different functions of the active pharmacy ingredient, the drugs. Low temperature transitions, by DEA including melting of frozen solvents, e.g. water, are more definitive than observed by low temperature DSC. Millions of dollars are expended annually on pharmaceutical testing to qualify excipients for fully …
Disintegration Of Tablets And Capsules Measured By Isothermal Thermal Mechanical Analysis And Macrophotography, Visweswararao Badipatla
Disintegration Of Tablets And Capsules Measured By Isothermal Thermal Mechanical Analysis And Macrophotography, Visweswararao Badipatla
ETD Archive
The current United States Pharmacopoeia (USP) test for tablet and encapsulated drug disintegration does not specify the initial disintegration time and provides limited information on the disintegration process itself. An isothermal Thermal Mechanical Analysis (IsoTMA) method is presented to measure the rate and initial time of drug disintegration, that is, the mechanical collapse of the gelatin capsule or the solid tablet. This method monitors changes in the dimensions of the formulated drugs during their disintegration in a liquid. Dimensional changes can be followed as a function of time, temperature, applied stress and pH. Some of the drugs studied were Olanzapine®, …