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Full-Text Articles in Physical Sciences and Mathematics
Role Of Ros And Rns Sources In Physiological And Pathological Conditions, Sergio Di Meo, Tanea Reed, Paola Venditti, Victor Manuel Victor
Role Of Ros And Rns Sources In Physiological And Pathological Conditions, Sergio Di Meo, Tanea Reed, Paola Venditti, Victor Manuel Victor
EKU Faculty and Staff Scholarship
There is significant evidence that, in living systems, free radicals and other reactive oxygen and nitrogen species play a double role, because they can cause oxidative damage and tissue dysfunction and serve as molecular signals activating stress responses that are beneficial to the organism. Mitochondria have been thought to both play a major role in tissue oxidative damage and dysfunction and provide protection against excessive tissue dysfunction through several mechanisms, including stimulation of opening of permeability transition pores. Until recently, the functional significance of ROS sources different from mitochondria has received lesser attention. However, the most recent data, besides confirming …
Harmful And Beneficial Role Of Ros, Sergio Di Meo, Tanea Reed, Paola Venditti, Victor M. Victor
Harmful And Beneficial Role Of Ros, Sergio Di Meo, Tanea Reed, Paola Venditti, Victor M. Victor
EKU Faculty and Staff Scholarship
Reactive oxygen species (ROS) are an unavoidable byproduct of oxygen metabolism and their cellular concentrations are determined by the balance between their rates of production and their rates of clearance by various antioxidant compounds and enzymes. For a long time ROS were thought to cause exclusively toxic effects which were associated with various pathologies, including carcinogenesis, neurodegeneration, atherosclerosis, diabetes, and aging. However, to date, it is known that while prolonged exposure to high ROS concentrations may lead to various disorders, low ROS concentrations exert beneficial effects regulating cell signaling cascades.