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Full-Text Articles in Physical Sciences and Mathematics
Engineering The Nano-Bio Interface Of Gold Nanoparticles For Biomedical Applications, Ying Jiang
Engineering The Nano-Bio Interface Of Gold Nanoparticles For Biomedical Applications, Ying Jiang
Doctoral Dissertations
Gold nanoparticles (AuNPs) have emerged as a promising platform for a myriad of biomedical applications, including sensing, drug delivery, and antibiotics. In this thesis, I have studied and engineered the interface of AuNPs with different biological systems, demonstrating a large variety of biomedical applications by modulation of these interfaces. My research was initially focused on systematically tuning the physicochemical properties of nanoparticles to understand nano-bio interactions at the cellular level. The results demonstrate that size and surface charge of AuNP interact in an interrelated fashion to modulate nanoparticle internalization by cells, providing an engineering strategy for designing nanomaterials for drug …
Design Of Romp-Based Protein Mimics For Sirna Delivery, Brittany M. Deronde
Design Of Romp-Based Protein Mimics For Sirna Delivery, Brittany M. Deronde
Doctoral Dissertations
Designing delivery agents for therapeutics is an ongoing challenge. As treatments and desired cargoes become more complex, the need for improved delivery vehicles becomes critical. Excellent delivery vehicles must ensure the stability of the cargo, maintain the cargo’s solubility, and promote efficient delivery and release. In order to address these issues, many research groups have looked to nature for design inspiration. Proteins, such as HIV-1 TAT and Antennapedia homeodomain protein, are capable of crossing cellular membranes. However, due to the complexities of their structures, they are synthetically challenging to reproduce in the laboratory setting. Being able to incorporate the key …