Physical Sciences and Mathematics Commons^™

Liposomal Encapsulation Of Silver Nanoparticles To Enhance Nanoparticle Cytotoxicity And Modulate Induced Inflammatory Responses In Vitro, Azeez Yusuf

Doctoral

High concentrations of silver nanoparticles (AgNP) are increasingly present as active ingredient in everyday consumable products for antibacterial purposes causing increased human exposure and high risk of adverse effect development. In this thesis, AgNP were encapsulated in dipalmitoyl phosphatidylcholine (DPPC)-based liposome (forming Lipo-AgNP), to enhance intracellular delivery and associated cytotoxicity, and suppress AgNP-induced inflammation. It was noted that as a result of the encapsulation, Lipo-AgNP induced significantly reduced cell viability of THP1 monocytes and THP1 differentiated macrophages (TDM) at a notably lower dose than that of uncoated AgNP. The induced cytotoxicity was shown to result in an increased level of …