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Peroxynitrite Chemistry: Formation, Decomposition And Possible Deactivation Mechanisms By Thiols, Olufunke Modupe Olagunju
Peroxynitrite Chemistry: Formation, Decomposition And Possible Deactivation Mechanisms By Thiols, Olufunke Modupe Olagunju
Dissertations and Theses
Kinetics of formation and decomposition of peroxynitrite was studied in acidic and buffer solutions. Peroxynitrous acid was formed in acidic media by the reaction of H2O2 with HNO2 and NO +. Bimolecular rate constant for reaction of H2O2 with HNO2 at 25°C was determined to be 3.7 × 10 3 M-1 s-1. Peroxynitrous acid formed is highly unstable with half life of approximately 1 second. Decomposition of peroxynitrite is highly pH-dependent. In acidic media, peroxynitrous acid decomposes to nitrate while at neutral to slightly basic media, products of decomposition …