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Synthetic Studies On Small Molecule Modulators Of Src Homology 2 (Sh2) Domain-Containing Inositol 5’-Phosphatase (Ship), Otto Milhous Dungan

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Small molecule modulators of SH2-containing inositol 5’-phosphatase (SHIP) have recently become a hotly pursued area in medicinal chemistry. Pharmaceutical targeting of SHIP with small molecules has been identified as a new method to directly influence the phosphoinositide 3-kinase (PI3K) cell signaling pathway. Modulation of this pathway may be utilized in the development of interesting new therapeutics. A better understanding of the role that SHIP phosphatase activity plays in a number of disease states ranging from cancer to autoimmune disease to obesity may be ascertained by use of small molecule inhibitors. These investigations involved the synthesis of aminosteroid inhibitors and a …