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Dissertations (1934 -)

Theses/Dissertations

2018

Articles 1 - 8 of 8

Full-Text Articles in Physical Sciences and Mathematics

Developing Accessible Collection And Presentation Methods For Observational Data, Drew Marie Williams Oct 2018

Developing Accessible Collection And Presentation Methods For Observational Data, Drew Marie Williams

Dissertations (1934 -)

The processes of collecting, cleaning, and presenting data are critical in ensuring the proper analysis of data at a later date. An opportunity exists to enhance the data collection and presentation process for those who are not data scientists – such as healthcare professionals and businesspeople interested in using data to help them make decisions. In this work, creating an observational data collection and presentation tool is investigated, with a focus on developing a tool prioritizing user-friendliness and context preservation of the data collected. This aim is achieved via the integration of three approaches to data collection and presentation.In …

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Design, Synthesis And Study Of Redox And Optoelectronic Properties Of Aromatic Oxidants And Polycyclic Aromatic Hydrocarbons, Mohammad Mosharraf Hossain Jul 2018

Design, Synthesis And Study Of Redox And Optoelectronic Properties Of Aromatic Oxidants And Polycyclic Aromatic Hydrocarbons, Mohammad Mosharraf Hossain

Dissertations (1934 -)

Organic materials play a significant role for the next generation photovoltaic devices that convert solar energy into usable forms of energy. In this regard, polycyclic aromatic hydrocarbons (PAHs) are fundamental tools in the developing area of molecular electronics and photovoltaics as they show excellent optical/electronic properties and are well-suited for applications in such developing areas as flexible display devices, field effect transistors and solar cell panels. Design and synthesis of novel materials for photovoltaics applications would require the proper understanding the mechanism of charge transport and identification of the structural features necessary in a particular molecular wire or PAH. To …

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The Photodynamic And Structural Analyses Of Advanced Materials For Solar Fuel Conversion, Brian Pattengale Jul 2018

The Photodynamic And Structural Analyses Of Advanced Materials For Solar Fuel Conversion, Brian Pattengale

Dissertations (1934 -)

Mitigating the current and future climate and pollution issues that have been brought on by the combustion of fossil fuels is of utmost importance and will rely on, in part, the availability of renewable fuel sources. Of the possible sources of energy, solar is abundant, but must be harnessed efficiently and stored as a solar fuel to overcome the current storage issues that limit photovoltaic cells. One such fuel, H2(g), represents a carbon-neutral source of energy if it can be efficiently liberated from water via the water splitting reaction. Thus, much attention is focused on designing materials to perform the …

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Inference And Analysis Of Multilayered Mirna-Mediated Networks In Cancer, Duc Do Jul 2018

Inference And Analysis Of Multilayered Mirna-Mediated Networks In Cancer, Duc Do

Dissertations (1934 -)

MicroRNAs (miRNAs) are small noncoding transcripts that can regulate gene expression, thereby controlling diverse biological processes. Aberrant disruptions of miRNA expression and their interactions with other biological agents (e.g., coding and noncoding transcripts) have been associated with several types of cancer. The goal of this dissertation is to use multidimensional genomic data to model two different gene regulation mechanisms by miRNAs in cancer. This dissertation results from two research projects. The first project investigates a miRNA-mediated gene regulation mechanism called competing endogenous RNA (ceRNA) interactions, which suggests that some transcripts can indirectly regulate one another's activity through their interactions with …

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Photochemical Expulsion Of Leaving Groups From A Naphthothiophene-2-Carboxamide Linked To A Chromophore, Lingzi Li Jul 2018

Photochemical Expulsion Of Leaving Groups From A Naphthothiophene-2-Carboxamide Linked To A Chromophore, Lingzi Li

Dissertations (1934 -)

Two bichromophoric systems were synthesized which have thioxanthone as the chromophore that absorbs the incident light and a naphthothiophene-2-carboxanilide, which serves as a triplet excited state energy acceptor. Upon excitation the triplet excited state of the thioxanthone is populated via intersystem crossing, which is efficient with isc = 0.68. Based on the relative energies of the triplet excited states of thioxanthone (ET = 65 kcal mol-1) and naphthothiophene (ET = 51 kcal mol-1), the subsequent triplet excited state energy transfer to generate the triplet excited state of the naphthothiophene-2-carboxamide should be a very rapid process that is 14 kcal mol1 …

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Synthesis And Characterization Of Biomimetic Models Of Mononuclear Nonheme Iron Dioxygenases And Their Reactive Intermediates, Anne Alyse Fischer Apr 2018

Synthesis And Characterization Of Biomimetic Models Of Mononuclear Nonheme Iron Dioxygenases And Their Reactive Intermediates, Anne Alyse Fischer

Dissertations (1934 -)

Mononuclear non-heme iron dioxygenases (MNIDs) are a class of enzymes that catalyze a variety of reactions, from amino acid catabolism to bioremediation using molecular oxygen. This work focuses on three types of MNIDs: thiol dioxygenaes (TDOs), aminophenoldioxygenases (APDOs), and sulfoxide synthases (SOSs). TDOs, found in mammals, regulate the levels of cysteine along with other thiol-containing molecules, using molecular oxygen to convert them into their corresponding sulfinic acids. APDOs catalyze the oxidative ring cleavage in the biodegradation of nitroaromatics. SOSs are involved in the biosynthesis of large biologically relevant molecules in humans. Although this class of enzymes has gained more attention …

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Compressed Sensing For Few-View Multi-Pinhole Spect With Applications To Preclinical Imaging, Benjamin Michael Rizzo Apr 2018

Compressed Sensing For Few-View Multi-Pinhole Spect With Applications To Preclinical Imaging, Benjamin Michael Rizzo

Dissertations (1934 -)

Single Photon Emission Computed Tomography (SPECT) can be used to identify and quantify changes in molecular and cellular targets involved in disease. A radiopharmaceutical that targets a specific metabolic function is administered to a subject and planar projections are formed by imaging emissions at different view angles around the subject. The reconstruction task is to determine the distribution of radioactivity within the subject from the projections. We present a reconstruction approach that utilizes only a few view angles, resulting in a highly underdetermined system, which could be used for dynamic imaging applications designed to quantify physiologic processes altered with disease. …

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Photoremovable Protecting Groups Based On Electrocyclization With Leaving Group Expulsion Via A Proposed Zwitterion, Gilbert Ndzeidze Apr 2018

Photoremovable Protecting Groups Based On Electrocyclization With Leaving Group Expulsion Via A Proposed Zwitterion, Gilbert Ndzeidze

Dissertations (1934 -)

The triplet excited state of thioxanthone produced by photolysis undergoes reversible triplet energy transfer with a trimethylene - linked benzothiophene-2-carboxanilide ring system. The ensuing electrocyclic ring closure of the anilide moiety produces a putative zwitterionic intermediate that is capable of expelling leaving groups (LG-) from the C-3 position of the benzothiophene ring. Stern-Volmer quenching studies with cyclohexadiene as quencher furnish the rate constants for the triplet excitation transfer in the forward and reverse directions, which can be expressed as an equilibrium constant K = 0.058. Overall, the rate of triplet excited state reaction becomes K x kr = 5.7 x …

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