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The Application Of Bayesian Adaptive Design And Markov Model In Clinical Trials, Xiaoyu Lu
The Application Of Bayesian Adaptive Design And Markov Model In Clinical Trials, Xiaoyu Lu
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In this research, two new designs in clinical trials are proposed. The first problem is a new Bayesian adaptive dose-finding design and its application in an oncology clinical trial. This design is used for phase IB studies with the biomarker as the endpoint and with the fewer patients. The second problem is another new Bayesian adaptive dose-finding design with longitudinal analysis and its application in phase II depression clinical trial. This design is best fit for phase II dosing-finding clinical trials with clinical endpoints. MTD information has been obtained before the trials.
In adaptive dose-finding clinical trials, the strategy is …